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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/67581
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dc.contributor.authorRostom de Mello, Maria Alice-
dc.contributor.authorLuciano, Eliete-
dc.contributor.authorMagalhães Carneiro, Everardo-
dc.contributor.authorQueiroz Latorraca, Márcia-
dc.contributor.authorMachado de Oliveira, Camila Aparecida-
dc.contributor.authorBoschero, Antonio Carlos-
dc.date.accessioned2014-05-27T11:21:00Z-
dc.date.accessioned2016-10-25T18:19:15Z-
dc.date.available2014-05-27T11:21:00Z-
dc.date.available2016-10-25T18:19:15Z-
dc.date.issued2003-12-01-
dc.identifier.citationResearch Communications in Molecular Pathology and Pharmacology, v. 113-114, p. 229-246.-
dc.identifier.issn1078-0297-
dc.identifier.urihttp://hdl.handle.net/11449/67581-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/67581-
dc.description.abstractIn the present work, we examined the effects of feeding a low protein diet during pregnancy on glucose-induced insulin secretion and glucose homeostasis in rats. Young (60 days), pregnant (P) or non-pregnant (NP) rats were fed during pregnancy or for 21 days (the NP) a normal (17%) or a low (6%) protein diet. Serum glucose and insulin levels and pancreas insulin content in the fed state; total area under serum glucose curve (AG) after a glucose load and serum glucose disappearance rate (Kitt) after insulin administration; as well as 86Rb outflow, 45Ca uptake and insulin secretion by isolated pancreatic islets in response to glucose were evaluated. Serum glucose was lower in 17%-P (12%) and 6%-P (27%) than in corresponding NP-rats. Serum insulin was higher in 17%- P (153%) and 6%-P (77%) compared to the corresponding NP-rats. Pancreatic insulin was higher in 6%-rats (55%) than in 17%-rats. No differences were found in AG among the groups whereas Kitt was lower in 6%-NP and higher in 6%-P than in the equivalent 17% rats. Increasing glucose concentration from 2.8 to 16.7 mmol/l, reduced 86Rb outflow from isolated islets from all groups. Increasing glucose concentration from 2.8 to 16.7 mmol/l elevated 45Ca uptake by 17%-NP (47%), 17%-P (40%) and 6%-P (214%) islets but not by 6%-NP ones. The increase in 45Ca uptake was followed by an increase in insulin release by the 17%-NP (2767%), 17%-P (2850%) and 6%-P (1200%) islets. In conclusion, 6%-P rats show impaired glucose induced insulin secretion related to reduced calcium uptake by pancreatic islets. However, the poor insulin secretion did not fully compensate the high peripheral sensitivity to the hormone, resulting in hypoglycemia.en
dc.format.extent229-246-
dc.language.isoeng-
dc.sourceScopus-
dc.subject45Ca uptake-
dc.subject86Rb outflow-
dc.subjectGlucose metabolism-
dc.subjectInsulin secretion-
dc.subjectPancreatic islets-
dc.subjectPregnancy-
dc.subjectProtein malnutrition-
dc.subjectRat-
dc.subjectcalcium-
dc.subjectglucose-
dc.subjectrubidium-
dc.subjectanimal experiment-
dc.subjectcalcium transport-
dc.subjectcontrolled study-
dc.subjectglucose blood level-
dc.subjectglucose homeostasis-
dc.subjectglucose metabolism-
dc.subjectinsulin blood level-
dc.subjectinsulin release-
dc.subjectnonhuman-
dc.subjectpancreas islet-
dc.subjectpregnancy-
dc.subjectpriority journal-
dc.subjectprotein diet-
dc.subjectprotein restriction-
dc.subjectrat-
dc.subjectAnimals-
dc.subjectCalcium-
dc.subjectFatty Acids, Nonesterified-
dc.subjectFemale-
dc.subjectGlucose-
dc.subjectHomeostasis-
dc.subjectInsulin-
dc.subjectIslets of Langerhans-
dc.subjectLiver-
dc.subjectProtein Deficiency-
dc.subjectRats-
dc.subjectRats, Wistar-
dc.titleGlucose homeostasis in pregnant rats submitted to dietary protein restrictionen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade Federal de Mato Grosso (UFMT)-
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)-
dc.description.affiliationDepartamento de Educacao Fisica UNESP, Rio Claro, SP-
dc.description.affiliationDepartamento de Nutricao e Dietetica FEN UFMT, Cuiabá, MT-
dc.description.affiliationDepto. de Fisiologia e Biofisica UNICAMP, Campinas, SP-
dc.description.affiliationDepartamento de Educacao Fisica UNESP, Av. 24-A, 1515, 13506-900 Rio Claro, SP-
dc.description.affiliationUnespDepartamento de Educacao Fisica UNESP, Rio Claro, SP-
dc.description.affiliationUnespDepartamento de Educacao Fisica UNESP, Av. 24-A, 1515, 13506-900 Rio Claro, SP-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofResearch Communications in Molecular Pathology and Pharmacology-
dc.identifier.scopus2-s2.0-13144266686-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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