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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/67730
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dc.contributor.authorColombo, Jucimara-
dc.contributor.authorRossit, Andreéa Regina Baptista-
dc.contributor.authorCaetano, Alaor-
dc.contributor.authorBorim, Aldenis Albaneze-
dc.contributor.authorWornrath, Durval-
dc.contributor.authorSilva, Ana Elizabete-
dc.date.accessioned2014-05-27T11:21:04Z-
dc.date.accessioned2016-10-25T18:19:35Z-
dc.date.available2014-05-27T11:21:04Z-
dc.date.available2016-10-25T18:19:35Z-
dc.date.issued2004-05-01-
dc.identifierhttp://www.wjgnet.com/1007-9327/full/v10/i9/1240.htm-
dc.identifier.citationWorld Journal of Gastroenterology, v. 10, n. 9, p. 1240-1245, 2004.-
dc.identifier.issn1007-9327-
dc.identifier.urihttp://hdl.handle.net/11449/67730-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/67730-
dc.description.abstractAim: To test the hypothesis that, in the Southeastern Brazilian population, the GSTT1, GSTM1 and CYP2E1 polymorphisms and putative risk factors are associated with an increased risk for gastric cancer. Methods: We conducted a study on 100 cases of gastric cancer (GC), 100 cases of chronic gastritis (CG), and 150 controls (C). Deletion of the GSTT1 and GSTM1 genes was assessed by multiplex PCR. CYP2E1/PstI genotyping was performed using a PCR-RFLP assay. Results: No relationship between GSTT1/GSTM1 deletion and the c1/c2 genotype of CYP2E1 was observed among the three groups. However, a significant difference between CG and C was observed, due to a greater number of GSTT1/GSTM1 positive genotypes in the CG group. The GSTT1 null genotype occurred more frequently in Negroid subjects, and the GSTM1 null genotype in Caucasians, while the GSTM1 positive genotype was observed mainly in individuals with chronic gastritis infected with H pylori. Conclusion: Our findings indicate that there is no obvious relationship between the GSTT1, GSTM1 and CYP2E1 polymorphisms and gastric cancer. Copyright © 2004 by The WJG Press.en
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
dc.format.extent1240-1245-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectcytochrome P450 2E1-
dc.subjectglutathione transferase-
dc.subjectadult-
dc.subjectaged-
dc.subjectBrazil-
dc.subjectcancer risk-
dc.subjectCaucasian-
dc.subjectchronic gastritis-
dc.subjectcontrolled study-
dc.subjectcorrelation analysis-
dc.subjectdisease association-
dc.subjectfemale-
dc.subjectfrequency analysis-
dc.subjectgene deletion-
dc.subjectgenetic polymorphism-
dc.subjectgenotype-
dc.subjectgeographic distribution-
dc.subjectHelicobacter infection-
dc.subjectHelicobacter pylori-
dc.subjecthuman-
dc.subjecthypothesis-
dc.subjectmajor clinical study-
dc.subjectmale-
dc.subjectNegro-
dc.subjectnull allele-
dc.subjectpolymerase chain reaction-
dc.subjectpopulation research-
dc.subjectrestriction fragment length polymorphism-
dc.subjectrisk factor-
dc.subjectstomach cancer-
dc.subjectAdolescent-
dc.subjectAdult-
dc.subjectAged-
dc.subjectAged, 80 and over-
dc.subjectCase-Control Studies-
dc.subjectChronic Disease-
dc.subjectCytochrome P-450 CYP2E1-
dc.subjectFemale-
dc.subjectGastritis-
dc.subjectGenotype-
dc.subjectGlutathione Transferase-
dc.subjectHumans-
dc.subjectMale-
dc.subjectMiddle Aged-
dc.subjectPolymorphism, Genetic-
dc.subjectRisk Factors-
dc.subjectStomach Neoplasms-
dc.titleGSTT1, GSTM1 and CYP2E1 genetic polymorphisms in gastric cancer and chronic gastritis in a Brazilian populationen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionFaculdade de Medicina de São José do Rio Preto (FAMERP)-
dc.contributor.institutionFundação Pio XII-
dc.description.affiliationDepartamento de Biologia UNESP Campus de São do Rio Preto, Rua Cristovão, Colombo 2265, 15054-000 - Sao Jose do Rio Preto-
dc.description.affiliationDept. de Doencas Dermatol. Infecc. Faculdade de Medicina FAMERP, Sao Jose do Rio Preto, SP-
dc.description.affiliationHospital de Base Faculdade de Medicina FAMERP, Sao Jose do Rio Preto, SP-
dc.description.affiliationFundação Pio XII, Barretos-
dc.description.affiliationUnespDepartamento de Biologia UNESP Campus de São do Rio Preto, Rua Cristovão, Colombo 2265, 15054-000 - Sao Jose do Rio Preto-
dc.identifier.wosWOS:000208097800003-
dc.rights.accessRightsAcesso aberto-
dc.identifier.file2-s2.0-4444277920.pdf-
dc.relation.ispartofWorld Journal of Gastroenterology-
dc.identifier.scopus2-s2.0-4444277920-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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