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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/67818
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dc.contributor.authorSpolidório, Luis Carlos-
dc.contributor.authorSpolidorio, D. M.-
dc.contributor.authorHolzhausen, M.-
dc.date.accessioned2014-05-27T11:21:07Z-
dc.date.accessioned2016-10-25T18:19:46Z-
dc.date.available2014-05-27T11:21:07Z-
dc.date.available2016-10-25T18:19:46Z-
dc.date.issued2004-08-01-
dc.identifierhttp://dx.doi.org/10.1111/j.1600-0765.2004.00734.x-
dc.identifier.citationJournal of Periodontal Research, v. 39, n. 4, p. 257-262, 2004.-
dc.identifier.issn0022-3484-
dc.identifier.urihttp://hdl.handle.net/11449/67818-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/67818-
dc.description.abstractBackground: The treatment of cyclosporin A triggers an early bone loss and gingival overgrowth. There is a lack of studies exploring the effects of long-term cyclosporin A therapy on alveolar bone homeostasis and gingival tissue. Objective: The purpose of this study was to evaluate the effects of long-term therapy with cyclosporin A on the gingival tissue and on the alveolar bone metabolism in rats. Materials and methods: Rats were treated for 60, 120, 180 and 240 days with a daily subcutaneous injection of 10 mg/kg body weight of cyclosporin A. At the end of experimental periods, animals were killed and the serum calcium (Ca2+) and alkaline phosphatase levels were measured in all groups. After histological processing, the oral epithelium and the connective tissue, as well as volume densities of alveolar bone (Vb) and multinucleated osteoclasts (Vo), were assessed at the region of the lower first molars. Results: Significant increases in the serum alkaline phosphatase were observed in those groups that received cyclosporin A therapy. After 60 and 120 days of the treatment with cyclosporin A, evident gingival overgrowth associated with a significant increase of epithelium and connective tissue was observed, as well as a decrease of the densities of bone and an increase of densities of osteoclasts. After 180 and 240 days of the treatment, there was a reduction of the gingival overgrowth associated with significant decreases of epithelium and connective tissue, as well as an increase of bone densities and a decrease of osteoclasts. Conclusion: Within the limits of this experimental study, it can be concluded that the deleterious periodontal effects of cyclosporin A administration may be time-related side-effects. © Blackwell Munksgaard, 2004.en
dc.format.extent257-262-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectAlveolar bone loss-
dc.subjectCyclosporin A-
dc.subjectGingival overgrowth-
dc.subjectalkaline phosphatase-
dc.subjectcalcium ion-
dc.subjectcyclosporin A-
dc.subjectalveolar bone-
dc.subjectanimal tissue-
dc.subjectbone density-
dc.subjectcalcium blood level-
dc.subjectcell density-
dc.subjectcontrolled study-
dc.subjectenzyme blood level-
dc.subjectgingiva overgrowth-
dc.subjectlong term care-
dc.subjectmale-
dc.subjectnonhuman-
dc.subjectosteoclast-
dc.subjectperiodontium-
dc.subjectrat-
dc.subjectAlkaline Phosphatase-
dc.subjectAlveolar Bone Loss-
dc.subjectAlveolar Process-
dc.subjectAnimals-
dc.subjectBone Density-
dc.subjectCalcium-
dc.subjectCell Count-
dc.subjectConnective Tissue-
dc.subjectCyclosporine-
dc.subjectDisease Models, Animal-
dc.subjectEpithelium-
dc.subjectGingiva-
dc.subjectGingival Overgrowth-
dc.subjectHomeostasis-
dc.subjectImmunosuppressive Agents-
dc.subjectInjections, Subcutaneous-
dc.subjectMale-
dc.subjectOsteoclasts-
dc.subjectPeriodontium-
dc.subjectRats-
dc.subjectRats, Wistar-
dc.subjectTime Factors-
dc.titleEffects of long-term cyclosporin therapy on the periodontium of ratsen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationDepartment of Oral Pathology Dental School, Araraquara Univ. of State of São Paulo, São Paulo-
dc.description.affiliationDepartment of Periodontology Dental School, Araraquara Univ. of State of São Paulo, São Paulo-
dc.description.affiliationDepartment of Pathology Univ. of State of São Paulo Dental School, R. Humaitá, 1680, C. P. 331, São Paulo, CEP: 14801-903-
dc.identifier.doi10.1111/j.1600-0765.2004.00734.x-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofJournal of Periodontal Research-
dc.identifier.scopus2-s2.0-3242811126-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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