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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/68130
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dc.contributor.authorde Andrade, James N.B.M.-
dc.contributor.authorCamacho, Aparecido A.-
dc.contributor.authorSantos, Paulo S.P.-
dc.contributor.authorFantinatti, Alexandra P.-
dc.contributor.authorNunes, Newton-
dc.contributor.authorStopiglia, Angelo J.-
dc.date.accessioned2014-05-27T11:21:16Z-
dc.date.accessioned2016-10-25T18:20:28Z-
dc.date.available2014-05-27T11:21:16Z-
dc.date.available2016-10-25T18:20:28Z-
dc.date.issued2005-02-01-
dc.identifierhttp://dx.doi.org/10.2460/ajvr.2005.66.238-
dc.identifier.citationAmerican Journal of Veterinary Research, v. 66, n. 2, p. 238-243, 2005.-
dc.identifier.issn0002-9645-
dc.identifier.urihttp://hdl.handle.net/11449/68130-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/68130-
dc.description.abstractObjective - To evaluate plication of the free wall of the left ventricle, which reduces the left ventricular area and volume, as a method to improve the left ventricular systolic function without cardiopulmonary bypass. Animals - 8 mixed-breed adult dogs. Procedure - Dilated cardiomyopathy (DCM) was induced in each dog by administration of doxorubicin (30 mg/m2, IV, q 21 d for 168 days). Two dogs died during induction of cardiomyopathy. Plication surgery was performed in 4 dogs. Two dogs did not ondergo to surgery (control group). Values for cardiac output (CO), 2-dimensional and M-mode echocardiography, arterial blood pressure, electrocardiography, blood cell counts, and serum biochemical analyses were recorded after induction of DCM (baseline) and 1, 2, 7, 15, 21, 30, 60, 90, 120, 150, and 180 days after plication surgery. Ambulatory ECG (Holter) recordings were conducted for 24 hours on the day of surgery. Results - 1 dog died after plication surgery. The remaining dogs undergoing ventricular plication had a significant improvement in CO, ejection fraction, and fractional shortening and reductions of left ventricular area and volume after surgery. Electrocardiographic and Holter recordings revealed premature ventricular complexes, which resolved without treatment during the first week after surgery. Clinical condition of the control dogs declined, and these 2 dogs died approximately 40 days after induction of cardiomyopathy. Conclusions and Clinical Relevance - Plication of the free wall of the left ventricle improved left ventricular systolic function in dogs with doxorubicin-induced cardiomyopathy. Additional studies are needed to evaluate its application in dogs with naturally developing DCM.en
dc.format.extent238-243-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectdoxorubicin-
dc.subjectanimal experiment-
dc.subjectanimal model-
dc.subjectarterial pressure-
dc.subjectblood analysis-
dc.subjectblood cell count-
dc.subjectblood vessel wall-
dc.subjectcardiopulmonary bypass-
dc.subjectcongestive cardiomyopathy-
dc.subjectcontrolled study-
dc.subjectdeath-
dc.subjectdog disease-
dc.subjectdrug induced disease-
dc.subjectheart ejection fraction-
dc.subjectheart left ventricle-
dc.subjectheart left ventricle function-
dc.subjectheart left ventricle volume-
dc.subjectheart output-
dc.subjectheart surgery-
dc.subjectHolter monitoring-
dc.subjectM mode echocardiography-
dc.subjectnonhuman-
dc.subjectsurgical technique-
dc.subjecttreatment outcome-
dc.subjecttwo dimensional echocardiography-
dc.subjectAnimals-
dc.subjectAntibiotics, Antineoplastic-
dc.subjectCardiac Output-
dc.subjectCardiomyopathy, Dilated-
dc.subjectDisease Models, Animal-
dc.subjectDog Diseases-
dc.subjectDogs-
dc.subjectDoxorubicin-
dc.subjectEchocardiography-
dc.subjectStroke Volume-
dc.subjectSystole-
dc.subjectVentricular Remodeling-
dc.subjectAnimalia-
dc.subjectCanis familiaris-
dc.titlePlication of the free wall of the left ventricle in dogs with doxorubicin-induced cardiomyopathyen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.description.affiliationProg. de Pos-Grad./Cir. Veterinaria Fac. de Cie. Agrarias e Veterinarias Universidade Estadual Paulista, Campus de Jaboticabal, São Paulo-
dc.description.affiliationDepartamento de Clinica e Cirurgia Fac. de Cie. Agrarias e Veterinarias Universidade Estadual Paulista, Campus de Jaboticabal, São Paulo-
dc.description.affiliationDepartamento de Cirurgia FMVZ Universidade de São Paulo, São Paulo-
dc.description.affiliation, R. Dep. Atilio Almeida Barbosa 927, Curitiba, PR 82560-460-
dc.description.affiliationUnespProg. de Pos-Grad./Cir. Veterinaria Fac. de Cie. Agrarias e Veterinarias Universidade Estadual Paulista, Campus de Jaboticabal, São Paulo-
dc.description.affiliationUnespDepartamento de Clinica e Cirurgia Fac. de Cie. Agrarias e Veterinarias Universidade Estadual Paulista, Campus de Jaboticabal, São Paulo-
dc.identifier.doi10.2460/ajvr.2005.66.238-
dc.identifier.wosWOS:000226922600008-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofAmerican Journal of Veterinary Research-
dc.identifier.scopus2-s2.0-14844327777-
dc.identifier.orcid0000-0002-8535-5569pt
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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