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Importância da linha de base pré-exposição das colinesterases (ChEs) no controle ocupacional a praguicidas organofosforados e carbamatos
Other Titles: 
Importance of red cell and plasma cholinesterase pre-exposure baseline into monitoring organophosphate and carbamate pesticides occupational exposed workers
Universidade Estadual Paulista (UNESP)
The most immediate toxic effects of a poisoning for organophosphate or carbamate are promoted by inhibition of cholinesterases (ChEs). However, a serious limitation to the diagnosis of mild organophosphate or carbamate poisoning and to preventive screening of organophosphate-exposed workers has been the large interindividual variability in ChEs activity. This makes it necessary to obtain a pre-exposure baseline measurement of enzyme activity as a basis for evaluating subsequent declines. Thus, the objective of this work is demonstrate the value of the pre-exposure baseline in the interpretation of the results of the ChEs activity of the carbamate or organophosphate-exposed workers. Using Nabb & Whitfield (1967) method to analyze blood of 48 workers the results have shown a erythrocyte cholinesterase range of 10.1 to 19.7 μmol/min/mL and plasm cholinesterase range of 2.2 to 6.9 μmol/min/mL. Despite the large interindividual variation presented, when one used the pre-exposure baseline it was possible to correlate symptoms of light poisoning of the exposure workers to carbamate with fall in the Er-ChE activity lesser then 30% of the pre-exposure baseline activity.
Issue Date: 
Revista Brasileira de Toxicologia, v. 18, n. 1, p. 43-48, 2005.
Time Duration: 
  • Cholinesterases
  • Organophosphate, occupational exposure, baseline
  • carbamic acid
  • cholinesterase
  • organophosphate
  • pesticide
  • blood analysis
  • conference paper
  • correlation analysis
  • diagnostic value
  • enzyme activity
  • erythrocyte
  • human
  • intoxication
  • occupational exposure
  • occupational toxicology
  • symptom
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Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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