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DC Field | Value | Language |
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dc.contributor.author | Oliveira, Georgino H. | - |
dc.contributor.author | Gomes, Melissa M. | - |
dc.contributor.author | Drumond, Thais L. | - |
dc.date.accessioned | 2014-05-27T11:21:21Z | - |
dc.date.accessioned | 2016-10-25T18:20:49Z | - |
dc.date.available | 2014-05-27T11:21:21Z | - |
dc.date.available | 2016-10-25T18:20:49Z | - |
dc.date.issued | 2005-06-01 | - |
dc.identifier.citation | Revista Brasileira de Toxicologia, v. 18, n. 1, p. 43-48, 2005. | - |
dc.identifier.issn | 1415-2983 | - |
dc.identifier.uri | http://hdl.handle.net/11449/68273 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/68273 | - |
dc.description.abstract | The most immediate toxic effects of a poisoning for organophosphate or carbamate are promoted by inhibition of cholinesterases (ChEs). However, a serious limitation to the diagnosis of mild organophosphate or carbamate poisoning and to preventive screening of organophosphate-exposed workers has been the large interindividual variability in ChEs activity. This makes it necessary to obtain a pre-exposure baseline measurement of enzyme activity as a basis for evaluating subsequent declines. Thus, the objective of this work is demonstrate the value of the pre-exposure baseline in the interpretation of the results of the ChEs activity of the carbamate or organophosphate-exposed workers. Using Nabb & Whitfield (1967) method to analyze blood of 48 workers the results have shown a erythrocyte cholinesterase range of 10.1 to 19.7 μmol/min/mL and plasm cholinesterase range of 2.2 to 6.9 μmol/min/mL. Despite the large interindividual variation presented, when one used the pre-exposure baseline it was possible to correlate symptoms of light poisoning of the exposure workers to carbamate with fall in the Er-ChE activity lesser then 30% of the pre-exposure baseline activity. | en |
dc.format.extent | 43-48 | - |
dc.language.iso | por | - |
dc.source | Scopus | - |
dc.subject | Cholinesterases | - |
dc.subject | Organophosphate, occupational exposure, baseline | - |
dc.subject | carbamic acid | - |
dc.subject | cholinesterase | - |
dc.subject | organophosphate | - |
dc.subject | pesticide | - |
dc.subject | blood analysis | - |
dc.subject | conference paper | - |
dc.subject | correlation analysis | - |
dc.subject | diagnostic value | - |
dc.subject | enzyme activity | - |
dc.subject | erythrocyte | - |
dc.subject | human | - |
dc.subject | intoxication | - |
dc.subject | occupational exposure | - |
dc.subject | occupational toxicology | - |
dc.subject | symptom | - |
dc.title | Importância da linha de base pré-exposição das colinesterases (ChEs) no controle ocupacional a praguicidas organofosforados e carbamatos | pt |
dc.title.alternative | Importance of red cell and plasma cholinesterase pre-exposure baseline into monitoring organophosphate and carbamate pesticides occupational exposed workers | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista | - |
dc.description.affiliation | Estagiarias de Iniciacao Cientifica do Departamento de Principios Ativos Naturais e Toxicologia Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista | - |
dc.description.affiliation | Faculdade de Ciências Farmacêuticas UNESP, Rod. Araraquara-Jaú km 1, 14.801- 902 - Araraquara - Sao Paulo | - |
dc.description.affiliationUnesp | Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista | - |
dc.description.affiliationUnesp | Estagiarias de Iniciacao Cientifica do Departamento de Principios Ativos Naturais e Toxicologia Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista | - |
dc.description.affiliationUnesp | Faculdade de Ciências Farmacêuticas UNESP, Rod. Araraquara-Jaú km 1, 14.801- 902 - Araraquara - Sao Paulo | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Revista Brasileira de Toxicologia | - |
dc.identifier.scopus | 2-s2.0-27844472501 | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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