You are in the accessibility menu

Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/68282
Full metadata record
DC FieldValueLanguage
dc.contributor.authorMatsumoto, Silvia T.-
dc.contributor.authorMarin-Morales, Maria A.-
dc.date.accessioned2014-05-27T11:21:22Z-
dc.date.accessioned2016-10-25T18:20:51Z-
dc.date.available2014-05-27T11:21:22Z-
dc.date.available2016-10-25T18:20:51Z-
dc.date.issued2005-06-01-
dc.identifier.citationRevista Brasileira de Toxicologia, v. 18, n. 1, p. 77-85, 2005.-
dc.identifier.issn1415-2983-
dc.identifier.urihttp://hdl.handle.net/11449/68282-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/68282-
dc.description.abstractDuring the last years, the emission of heavy metals to the environment has increased, causing a severe negative impact to the ecosystems and seriously compromising human health due to their mutagenic potential. Tri- (III) and hexavalent (VI) chromium (Cr) constitute the oxidative states of the metal chromium that are active in living organisms. These two oxidation states of the chromium differ with regards to their cellular effects, mainly due to the different abilities they possess in relation to easy of transport through biological membranes. Cr VI is transported into the cell through transference channels of endogenous anions that are isostructural and isoelectronical to Cr VI, such as SO 4 -2 and HPO 4 -2. On the other hand, Cr III is unable to diffuse through the cell membrane. Its existence inside the cells is generally due to the reduction of Cr VI, the endocytosis, or the absortion by the cells via phagocytosis. Cr III acts directly on the DNA molecule, while Cr VI reacts little with this molecule. In the ecosystem, however, Cr VI is more dangerous since this is the form that presents greater reactivity with biological membranes, crossing them and being easily incorporated into the cell. In the cell it is biotransformed to Cr III, a potentially mutagenic molecule. In vivo and in vitro studies have shown that organisms exposed to Cr VI present greater induction to a variety of damages to the DNA molecule. Among the damages induced by Cr, changes in the structure of the DNA molecule have been reported, with breaks of the major chain and base oxidation. In the organisms, these alterations generate chromosomal aberrations, micronucleus formation, sister chromatid exchanges, and errors in DNA synthesis.en
dc.format.extent77-85-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectChromium-
dc.subjectGenotoxicity-
dc.subjectHeavy metal-
dc.subjectanion-
dc.subjectchromium-
dc.subjectDNA-
dc.subjectphosphate-
dc.subjectsulfate-
dc.subjectbiotransformation-
dc.subjectcell activity-
dc.subjectcell membrane-
dc.subjectchemical structure-
dc.subjectchromosome aberration-
dc.subjectconference paper-
dc.subjectDNA damage-
dc.subjectDNA structure-
dc.subjectDNA synthesis-
dc.subjectecosystem-
dc.subjectendocytosis-
dc.subjectenvironment-
dc.subjectgenotoxicity-
dc.subjecthealth-
dc.subjectin vitro study-
dc.subjectin vivo study-
dc.subjectmicronucleus-
dc.subjectmutagenicity-
dc.subjectoxidation-
dc.subjectphagocytosis-
dc.subjectreduction-
dc.subjectsister chromatid exchange-
dc.subjecttoxicity-
dc.titleToxic and genotoxic effects of trivalent and hexavalent chromium - A reviewen
dc.typeoutro-
dc.contributor.institutionUniversidade Federal do Espírito Santo (UFES)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniversidade Federal do Espírito Santo Departamento de Ciências Biológicas-
dc.description.affiliationUniversidade Estadual Paulista IB-Campus de Rio Claro, Rio Claro/SP-
dc.description.affiliationUniversidade Estadual Paulista IB-Campus de Rio Claro, Av.24-A, 1515, Cep: 13506-900, Rio Claro/SP-
dc.description.affiliationUnespUniversidade Estadual Paulista IB-Campus de Rio Claro, Rio Claro/SP-
dc.description.affiliationUnespUniversidade Estadual Paulista IB-Campus de Rio Claro, Av.24-A, 1515, Cep: 13506-900, Rio Claro/SP-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofRevista Brasileira de Toxicologia-
dc.identifier.scopus2-s2.0-27844546112-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

There are no files associated with this item.
 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.