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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/68318
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dc.contributor.authorde Oliveira Bello Corrêa, Fernanda-
dc.contributor.authorGiro, Gabriela-
dc.contributor.authorGonçalves, Daniela-
dc.contributor.authorSpolidório, Luis Carlos-
dc.contributor.authorOrrico, Silvana Regina Perez-
dc.date.accessioned2014-05-27T11:21:22Z-
dc.date.accessioned2016-10-25T18:20:54Z-
dc.date.available2014-05-27T11:21:22Z-
dc.date.available2016-10-25T18:20:54Z-
dc.date.issued2005-07-01-
dc.identifierhttp://dx.doi.org/10.1590/S1806-83242005000300002-
dc.identifier.citationBrazilian Oral Research, v. 19, n. 3, p. 163-168, 2005.-
dc.identifier.issn1806-8324-
dc.identifier.issn1807-3107-
dc.identifier.urihttp://hdl.handle.net/11449/68318-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/68318-
dc.description.abstractThe administration of calcium channel blockers has been associated with gingival overgrowth. However, there are few studies in humans or animals that evaluated the effect of diltiazem on gingival tissues. The present study assessed the influence of diltiazem, at different dosages and treatment duration, on gingival tissues of rats, using clinical, histological and histometric analyses. Eighty young male rats were separated into eight groups according to the dosage and duration of treatment. Rats were treated for 20 or 40 days with a daily subcutaneous injection of 5, 20 or 50 mg/kg of body weight of diltiazem. The results confirmed that diltiazem did not induce gingival overgrowth in rats. For all animals, the evaluation did not show gingival alterations regardless of the dosages and periods of treatment. The histometric analysis showed no significant change in the area of epithelium and connective tissues, although after 40 days of treatment a decrease in the area of connective tissue was observed, without statistically significant difference from control groups. Within the limits of this study, we suggest that diltiazem did not induce gingival overgrowth.en
dc.format.extent163-168-
dc.language.isopor-
dc.sourceScopus-
dc.subjectAntihypertensive agents-
dc.subjectDiltiazem-
dc.subjectGingival overgrowth-
dc.titleDiltiazem não induziu crescimento gengival em ratos. Análise clínica, histológica e histométricapt
dc.title.alternativeDiltiazem did not induce gingival overgrowth in rats. A clinical, histological and histometric analysisen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationDepartment of Diagnosis and Surgery São Paulo State University-
dc.description.affiliationDepartment of Physiology and Pathology São Paulo State University-
dc.description.affiliationDepartment of Diagnosis and Surgery School of Dentistry of Araraquara São Paulo State University-
dc.description.affiliationUnespDepartment of Diagnosis and Surgery São Paulo State University-
dc.description.affiliationUnespDepartment of Physiology and Pathology São Paulo State University-
dc.description.affiliationUnespDepartment of Diagnosis and Surgery School of Dentistry of Araraquara São Paulo State University-
dc.identifier.doi10.1590/S1806-83242005000300002-
dc.identifier.scieloS1806-83242005000300002-
dc.rights.accessRightsAcesso aberto-
dc.identifier.file2-s2.0-33747523130.pdf-
dc.relation.ispartofBrazilian Oral Research-
dc.identifier.scopus2-s2.0-33747523130-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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