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dc.contributor.authorRibeiro, Daniel Araki-
dc.contributor.authorMatsumoto, Mariza Akemi-
dc.contributor.authorDuarte, Marco Antonio Húngaro-
dc.contributor.authorMarques, Mariângela Esther Alencar-
dc.contributor.authorSalvadori, Daisy Maria Favero-
dc.identifier.citationBrazilian Oral Research, v. 19, n. 3, p. 183-187, 2005.-
dc.description.abstractRecently, regular and white mineral trioxide aggregate (MTA) are being used in Dentistry as retrofilling materials. Genotoxicity and cytotoxicity tests form an important part of cancer research and risk assessment of potential carcinogens. Thus, the goal of this study was to examine the genotoxicity and cytotoxicity of regular and white MTA in vitro by the single cell gel (comet) assay and trypan blue exclusion test, respectively. Mouse lymphoma cells were exposed to two presentation forms of MTA at final concentrations ranging from 1 to 1,000 μg/mL for 3 h at 37°C. The results showed that both compounds tested did not produce genotoxic effects at all concentrations evaluated. Likewise, no statistically significant differences (p > 0.05) were observed in cytotoxicity. Taken together, our results suggest that regular and white MTA are not genotoxins and are not able to interfere in cellular viability as assessed by single cell gel (comet) assay and trypan blue assay, respectively.en
dc.subjectComet assay-
dc.subjectGenotoxicity tests-
dc.subjectMineral trioxide aggregate-
dc.subjectMouse lymphoma cells-
dc.subjectTrypan blue-
dc.titleTestes de biocompatibilidade in vitro de duas formas comerciais do agregado de trióxido mineralpt
dc.title.alternativeIn vitro biocompatibility tests of two commercial types of mineral trioxide aggregateen
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversity of Sacred Heart-
dc.description.affiliationCenter for Genotoxin and Carcinogen Evaluation TOXICAN - Department of Pathology School of Medicine of Botucatu, São Paulo State University-
dc.description.affiliationDepartment of Dental Clinics University of Sacred Heart-
dc.description.affiliationUnespCenter for Genotoxin and Carcinogen Evaluation TOXICAN - Department of Pathology School of Medicine of Botucatu, São Paulo State University-
dc.rights.accessRightsAcesso aberto-
dc.relation.ispartofBrazilian Oral Research-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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