You are in the accessibility menu

Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/68332
Full metadata record
DC FieldValueLanguage
dc.contributor.authorLemos, Carla C. S.-
dc.contributor.authorMandarim-de-Lacerda, Carlos A.-
dc.contributor.authorDorigo, David-
dc.contributor.authorCoimbra, Terezila M.-
dc.contributor.authorBregman, Rachel-
dc.date.accessioned2014-05-27T11:21:23Z-
dc.date.accessioned2016-10-25T18:20:56Z-
dc.date.available2014-05-27T11:21:23Z-
dc.date.available2016-10-25T18:20:56Z-
dc.date.issued2005-07-01-
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/16245239-
dc.identifier.citationJournal of Nephrology, v. 18, n. 4, p. 368-373, 2005.-
dc.identifier.issn1121-8428-
dc.identifier.issn1724-6059-
dc.identifier.urihttp://hdl.handle.net/11449/68332-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/68332-
dc.description.abstractGender influences the progression of chronic renal failure (CRF). We studied male (M) and female (F) Wistar rats for 90 days: castrated (CMc, n=7; CFc, n=6) and non castrated controls (CM, n=9; CF, n=6); castrated (CRFMc, n=8; CRFFc, n=6) and non castrated animals submitted to 5/6 nephrectomy (CRFM, n=13; CRFF, n=6). Data are expressed as mean ± SEM. Proteinuria (PTN) was higher in CRFM (554 ± 69mg/24h) compared to CRFMc (277 ± 85 mg/24h), but not in females (CRFF=193 ± 20mg/24h, CRFFc=164 ± 71mg/24h). Mesangial fractional volume increased in all CRF animals. CRF animals showed an increase of glomerular sclerosis index (GSI) and tubulointerstitial damage (TID) but in a smaller proportion in male castrated animals; the opposite occurred with females: castration induced an increase of these parameters. CRF animals showed increased cortical and glomerular fibronectin (FN) rates. Castration decreased glomerular and cortical FN rates in CRFM but not in females. In conclusion, proteinuria was higher in CRFM and probably led to glomerular and interstitial damage, as well as to FN accumulation, castration seems to protect against development of PTN, TID and FN accumulation in males. Castrated female rats presented mesangial expansion, with no changes in PTN, TID and FN rates. It seems that female sex hormones do not protect against renal disease progression, instead, we suggest that male sex hormones lead to acceleration of CRF.en
dc.format.extent368-373-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectCastration-
dc.subjectChronic renal failure-
dc.subjectExtra-cellular matrix-
dc.subjectFibronectin-
dc.subjectGender-
dc.subjectMesangium-
dc.subjectfibronectin-
dc.subjectsex hormone-
dc.subjectanimal experiment-
dc.subjectanimal model-
dc.subjectanimal tissue-
dc.subjectcastration-
dc.subjectchronic kidney failure-
dc.subjectcontrolled study-
dc.subjectdisease course-
dc.subjectfemale-
dc.subjectglomerulosclerosis-
dc.subjectkidney cortex-
dc.subjectkidney injury-
dc.subjectmale-
dc.subjectmesangium-
dc.subjectnephrectomy-
dc.subjectnonhuman-
dc.subjectproteinuria-
dc.subjectrat-
dc.subjectrat strain-
dc.subjectrenal protection-
dc.subjectsex difference-
dc.subjectAnimals-
dc.subjectBiopsy-
dc.subjectDisease Models, Animal-
dc.subjectDisease Progression-
dc.subjectFemale-
dc.subjectFibronectins-
dc.subjectImmunoenzyme Techniques-
dc.subjectKidney Failure, Chronic-
dc.subjectKidney Glomerulus-
dc.subjectMale-
dc.subjectProteinuria-
dc.subjectRats-
dc.subjectRats, Wistar-
dc.subjectSex Factors-
dc.titleChronic renal failure in male and female ratsen
dc.typeoutro-
dc.contributor.institutionUniversidade do Estado do Rio de Janeiro (UERJ)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationNephrology Division University of the State of Rio de Janeiro, Rio de Janeiro-
dc.description.affiliationLaboratory of Morphometry University of the State of Rio de Janeiro, Rio de Janeiro-
dc.description.affiliationDepartment of Physiology University of the State of São Paulo, Ribeirão Preto-
dc.description.affiliation, Rua Soares Cabral 71/401, Rio de Janeiro 22240-070-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofJournal of Nephrology-
dc.identifier.scopus2-s2.0-28244442515-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

There are no files associated with this item.
 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.