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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/68337
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dc.contributor.authorCastro, J.-
dc.contributor.authorResende, Luan A.L.-
dc.contributor.authorBertotti, M. F Z-
dc.contributor.authorFonseca, Ronaldo Guimarães-
dc.contributor.authorZanchetta, S.-
dc.contributor.authorSchelp, Arthur Oscar-
dc.date.accessioned2014-05-27T11:21:23Z-
dc.date.accessioned2016-10-25T18:20:57Z-
dc.date.available2014-05-27T11:21:23Z-
dc.date.available2016-10-25T18:20:57Z-
dc.date.issued2005-07-01-
dc.identifier.citationElectromyography and Clinical Neurophysiology, v. 45, n. 5, p. 259-262, 2005.-
dc.identifier.issn0301-150X-
dc.identifier.urihttp://hdl.handle.net/11449/68337-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/68337-
dc.description.abstractThe aim of this study was to compare the effects of barbiturate, benzodiazepine and ketamine on flash-evoked potentials (F-VEP) in adult rabbits. A total of 36 animals were studied, 16 after pentobarbital endovenous (EV) inffusion, 10 after midazolam EV administration, and 10 after ketamine EV inffusion. Pentobarbital induced triphasic F-VEP, first negative (N1), secondpositive (P1), third negative (N2) waves, all with large amplitudes and P1 with well-defined morphology. Mean P1 latency was 33ms. Midazolam induced similar but less defind triphasic waves, with mean latency of 27ms. Ketamine induced poliphasic and poorly defined F-VEP, with mean first positive (P1) latency of 27ms. Statistical analysis showed more elongated latency for the pentobarbital group than the midazolam and ketamine groups. The results of this study suggest that the pharmacological effects of pentobarbital and midazolam on GABA neurotransmission in rabbit visual cortex may be different; another neurotransmission system, possibly cholinergic, may be involved. The ketamine effect seen in rabbit visual cortex seems to be different from pentobarbital and midazolam.en
dc.format.extent259-262-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectKetamine-
dc.subjectMidazolam-
dc.subjectPentobarbital-
dc.subjectVisual evoked potentials-
dc.subject4 aminobutyric acid-
dc.subjectketamine-
dc.subjectmidazolam-
dc.subjectpentobarbital-
dc.subjectamplitude modulation-
dc.subjectanimal experiment-
dc.subjectcholinergic transmission-
dc.subjectcontrolled study-
dc.subjectdrug effect-
dc.subjectevoked visual response-
dc.subjectfemale-
dc.subjectGABAergic transmission-
dc.subjectlatent period-
dc.subjectnonhuman-
dc.subjectvisual cortex-
dc.subjectwaveform-
dc.subjectwhite light-
dc.subjectAnesthetics, Dissociative-
dc.subjectAnimals-
dc.subjectBody Temperature-
dc.subjectEvoked Potentials, Visual-
dc.subjectFemale-
dc.subjectHypnotics and Sedatives-
dc.subjectPhenobarbital-
dc.subjectRabbits-
dc.subjectVisual Cortex-
dc.titleComparison of the effects of barbiturate, benzodiazepine and ketamine on visual evoked potentials in rabbitsen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationDepartment of Anaesthesiology Botucatu School of Medicine Unesp, 18618-000 Botacatu, SP-
dc.description.affiliationDepartment of Neurology and Psychiatry Botucatu School of Medicine Unesp, 18618-000 Botucatu, SP-
dc.description.affiliationUnespDepartment of Anaesthesiology Botucatu School of Medicine Unesp, 18618-000 Botacatu, SP-
dc.description.affiliationUnespDepartment of Neurology and Psychiatry Botucatu School of Medicine Unesp, 18618-000 Botucatu, SP-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofElectromyography and Clinical Neurophysiology-
dc.identifier.scopus2-s2.0-25444474981-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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