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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/68351
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dc.contributor.authorBelo, M. A A-
dc.contributor.authorSchalch, S. H C-
dc.contributor.authorMoraes, F. R.-
dc.contributor.authorSoares, V. E.-
dc.contributor.authorOtoboni, A. M M B-
dc.contributor.authorMoraes, J. E R-
dc.date.accessioned2014-05-27T11:21:23Z-
dc.date.accessioned2016-10-25T18:20:59Z-
dc.date.available2014-05-27T11:21:23Z-
dc.date.available2016-10-25T18:20:59Z-
dc.date.issued2005-08-01-
dc.identifierhttp://dx.doi.org/10.1016/j.jcpa.2005.04.004-
dc.identifier.citationJournal of Comparative Pathology, v. 133, n. 2-3, p. 146-154, 2005.-
dc.identifier.issn0021-9975-
dc.identifier.urihttp://hdl.handle.net/11449/68351-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/68351-
dc.description.abstractThe effect of dietary supplementation with 0, 100 and 450 mg of vitamin E (DL-α tocopheryl acetate)/kg of a dry diet on the kinetics of macrophage recruitment and giant cell formation in the pacu, maintained at different stocking densities (5 kg/m3 and 20 kg/m3), was investigated by insertion of round glass coverslips into the subcutaneous connective tissue. After a feeding period of 18 weeks, the coverslips were implanted and later removed for examination at 2, 7 and 15 days post-implantation. Fish fed diets supplemented with 450 mg of vitamin E showed an increase (P<0.05) in the accumulation of macrophages, foreign body giant cells and Langhans type cells. The kinetics of macrophage recruitment and giant cell formation on the glass coverslips appeared to be strongly influenced by vitamin E supplementation, since fish fed a basal diet and held at high stocking densities showed low numbers of adhering cells on the coverslips, and high concentrations of plasma corticosteroids. On the other hand, fish given a diet supplemented with 450 mg of vitamin E did not show a similar difference in plasma cortisol concentrations related to stocking density. The effect of cortisol concentrations on carbohydrate metabolism, analysed by assessment of plasma glycaemia, was not clear. Blood glucose concentrations did not vary substantially with the different treatments examined. These results suggest that vitamin E may contribute to the efficiency of the fish's inflammatory response by increasing macrophage recruitment and giant cell formation in the foreign body granulomatous reaction. Vitamin E appeared to act on the stress response of pacus by preventing a stress-related immunosuppression. © 2005 Elsevier Ltd. All rights reserved.en
dc.format.extent146-154-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectAlpha-tocopherolen
dc.subjectCortisolen
dc.subjectFishen
dc.subjectPiaractus mesopotamicusen
dc.subjectPolykaryon macrophageen
dc.subjectVitamin Een
dc.subjectalpha tocopherolen
dc.subjectcorticosteroiden
dc.subjectglucoseen
dc.subjecthydrocortisoneen
dc.subjectanimal cellen
dc.subjectanimal experimenten
dc.subjectcarbohydrate metabolismen
dc.subjectcell adhesionen
dc.subjectcell transporten
dc.subjectcontrolled studyen
dc.subjectcorticosteroid blood levelen
dc.subjectdiet supplementationen
dc.subjectfeedingen
dc.subjectglucose blood levelen
dc.subjectgranulomatosisen
dc.subjecthydrocortisone blood levelen
dc.subjectimmunosuppressive treatmenten
dc.subjectLanghans giant cellen
dc.subjectmacrophageen
dc.subjectnonhumanen
dc.subjectoxidative stressen
dc.subjectstocking densityen
dc.subjectteleosten
dc.subjecttransport kineticsen
dc.subjectAnimal Husbandryen
dc.subjectAnimalsen
dc.subjectBlood Glucoseen
dc.subjectCell Counten
dc.subjectCell Movementen
dc.subjectCrowdingen
dc.subjectDieten
dc.subjectDose-Response Relationship, Drugen
dc.subjectFishesen
dc.subjectForeign-Body Reactionen
dc.subjectGiant Cells, Foreign-Bodyen
dc.subjectHydrocortisoneen
dc.subjectLangerhans Cellsen
dc.subjectMacrophagesen
dc.subjectPopulation Densityen
dc.subjectTeleosteien
dc.titleEffect of dietary supplementation with vitamin E and stocking density on macrophage recruitment and giant cell formation in the teleost fish, Piaractus mesopotamicusen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationDepartment of Veterinary Pathology São Paulo State University Unesp, Jaboticabal-
dc.description.affiliationAquaculture Centre São Paulo State University Unesp, Jaboticabal-
dc.description.affiliationDepartment of Technology São Paulo State University Unesp, Jaboticabal-
dc.description.affiliationUnespDepartment of Veterinary Pathology São Paulo State University Unesp, Jaboticabal-
dc.description.affiliationUnespAquaculture Centre São Paulo State University Unesp, Jaboticabal-
dc.description.affiliationUnespDepartment of Technology São Paulo State University Unesp, Jaboticabal-
dc.identifier.doi10.1016/j.jcpa.2005.04.004-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofJournal of Comparative Pathology-
dc.identifier.scopus2-s2.0-23844436459-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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