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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/68357
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dc.contributor.authorAparecido Da Silva, Marcelo-
dc.contributor.authorMurino Rafacho, Bruna Paola-
dc.contributor.authorHiruma-Lima, Clelia Akiko-
dc.contributor.authorMachado Da Rocha, Lúcia Regina-
dc.contributor.authorCampaner Dos Santos, Lourdes-
dc.contributor.authorSannomiya, Miriam-
dc.contributor.authorMonteiro Souza-Brito, Alba Regina-
dc.contributor.authorVilegas, Wagner-
dc.date.accessioned2014-05-27T11:21:24Z-
dc.date.accessioned2016-10-25T18:21:00Z-
dc.date.available2014-05-27T11:21:24Z-
dc.date.available2016-10-25T18:21:00Z-
dc.date.issued2005-08-01-
dc.identifierhttp://dx.doi.org/10.1248/cpb.53.881-
dc.identifier.citationChemical and Pharmaceutical Bulletin, v. 53, n. 8, p. 881-885, 2005.-
dc.identifier.issn0009-2363-
dc.identifier.urihttp://hdl.handle.net/11449/68357-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/68357-
dc.description.abstractStrychnos pseudoquina St. Hil. (Loganiaceae) was investigated for its ability to protect the gastric mucosa against injuries caused by non-steroidal anti-inflammatory drugs (piroxicam) and a necrotizing agent (HCl/EtOH) in mice. The MeOH extract and enriched alkaloidic fraction (EAF) provided significant protection in experimental models wheer used at doses of 250 and 1000 mg/kg. In vivo tests were carried out to evaluate for possible toxic effects and no mortality was observed up to the 5 g/kg dose level. Phytochemical investigation led to the isolation of a new indole alkaloid, which elucidated the observed pharmacological effects. © 2005 Pharmaceutical Society of Japan.en
dc.format.extent881-885-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectAlkaloid-
dc.subjectAntiulcer activity-
dc.subjectStrychnos pseudoquina-
dc.subjectToxic activity-
dc.subjectpiroxicam-
dc.subjectplant extract-
dc.subjectstrychnos pseudoquina extract-
dc.subjectunclassified drug-
dc.subjectanimal experiment-
dc.subjectanimal model-
dc.subjectanimal tissue-
dc.subjectconcentration response-
dc.subjectcontrolled study-
dc.subjectdrug dose regimen-
dc.subjectdrug effect-
dc.subjectdrug isolation-
dc.subjectdrug screening-
dc.subjectin vivo study-
dc.subjectmale-
dc.subjectmedicinal plant-
dc.subjectmortality-
dc.subjectmouse-
dc.subjectnonhuman-
dc.subjectphytochemistry-
dc.subjectplant leaf-
dc.subjectstomach mucosa-
dc.subjectstomach protection-
dc.subjectstomach ulcer-
dc.subjectstrychnos pseudoquina-
dc.subjectAnimals-
dc.subjectAnti-Inflammatory Agents, Non-Steroidal-
dc.subjectDrug Evaluation, Preclinical-
dc.subjectGastric Mucosa-
dc.subjectMice-
dc.subjectPlant Extracts-
dc.subjectPlant Leaves-
dc.subjectStomach Ulcer-
dc.subjectStrychnos-
dc.titleEvaluation of Strychnos pseudoquina St. Hil. leaves extract on gastrointestinal activity in miceen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)-
dc.description.affiliationDepartamento de Química Orgânica Instituto de Química UNESP, c.p. 355, CEP 14800-900, Araraquara, SP-
dc.description.affiliationDepartamento de Fármacos e Medicamentos Faculdade de Ciências Farmacêuticas UNESP, CEP 14800-900, Araraquara, SP-
dc.description.affiliationDepartamento de Fisiologia Instituto de Biociências UNESP, c.p. 510, CEP 18618-000, Botucatu, SP-
dc.description.affiliationDepartamento de Fisiologia e Biofísica Instituto de Biologia UNICAMP, c.p. 6109, CEP 13083-970, Campinas, SP-
dc.description.affiliationUnespDepartamento de Química Orgânica Instituto de Química UNESP, c.p. 355, CEP 14800-900, Araraquara, SP-
dc.description.affiliationUnespDepartamento de Fármacos e Medicamentos Faculdade de Ciências Farmacêuticas UNESP, CEP 14800-900, Araraquara, SP-
dc.description.affiliationUnespDepartamento de Fisiologia Instituto de Biociências UNESP, c.p. 510, CEP 18618-000, Botucatu, SP-
dc.identifier.doi10.1248/cpb.53.881-
dc.identifier.wosWOS:000231320700002-
dc.rights.accessRightsAcesso aberto-
dc.relation.ispartofChemical and Pharmaceutical Bulletin-
dc.identifier.scopus2-s2.0-24944567759-
dc.identifier.orcid0000-0002-8645-3777pt
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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