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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/68369
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dc.contributor.authorFuruya, Daniela Tomie-
dc.contributor.authorBinsack, Ralf-
dc.contributor.authorOnishi, Mary Emy-
dc.contributor.authorSeraphim, Patricia Monteiro-
dc.contributor.authorMachado, Ubiratan Fabres-
dc.date.accessioned2014-05-27T11:21:35Z-
dc.date.accessioned2016-10-25T18:21:01Z-
dc.date.available2014-05-27T11:21:35Z-
dc.date.available2016-10-25T18:21:01Z-
dc.date.issued2005-08-26-
dc.identifierhttp://dx.doi.org/10.1016/j.lfs.2004.12.046-
dc.identifier.citationLife Sciences, v. 77, n. 15, p. 1813-1824, 2005.-
dc.identifier.issn0024-3205-
dc.identifier.urihttp://hdl.handle.net/11449/68369-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/68369-
dc.description.abstractModerate amounts of alcohol intake have been reported to have a protective effect on the cardiovascular system and this may involve enhanced insulin sensitivity. We established an animal model of increased insulin sensitivity by low ethanol consumption and here we investigated metabolic parameters and molecular mechanisms potentially involved in this phenomenon. For that, Wistar rats have received drinking water either without (control) or with 3% ethanol for four weeks. The effect of ethanol intake on insulin sensitivity was analyzed by insulin resistance index (HOMA-IR), intravenous insulin tolerance test (IVITT) and lipid profile. The role of liver was investigated by the analysis of insulin signaling pathway, GLUT2 gene expression and tissue glycogen content. Rats consuming 3% ethanol showed lower values of HOMA-IR and plasma free fatty acids (FFA) levels and higher hepatic glycogen content and glucose disappearance constant during the IVITT. Neither the phosphorylation of insulin receptor (IR) and insulin receptor substrate-1 (IRS-1), nor its association with phosphatidylinositol-3-kinase (PI3-kinase), was affected by ethanol. However, ethanol consumption enhanced liver IRS-2 and protein kinase B (Akt) phosphorylation (3 times, P < 0.05), which can be involved in the 2-fold increased (P < 0.05) hepatic glycogen content. The GLUT2 protein content was unchanged. Our findings point out that liver plays a role in enhanced insulin sensitivity induced by low ethanol consumption. © 2005 Elsevier Inc. All rights reserved.en
dc.format.extent1813-1824-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectAkt/PKB-
dc.subjectHepatic glycogen-
dc.subjectInsulin receptor substrate-2-
dc.subjectInsulin sensitivity-
dc.subjectLow-ethanol intake-
dc.subjectalcohol-
dc.subjectdrinking water-
dc.subjectfatty acid-
dc.subjectglucose-
dc.subjectglucose transporter 2-
dc.subjectglycogen-
dc.subjectinsulin-
dc.subjectinsulin receptor-
dc.subjectinsulin receptor substrate 1-
dc.subjectinsulin receptor substrate 2-
dc.subjectlipid-
dc.subjectphosphatidylinositol 3 kinase-
dc.subjectprotein kinase B-
dc.subjectalcohol consumption-
dc.subjectanimal experiment-
dc.subjectanimal tissue-
dc.subjectcontrolled study-
dc.subjectfatty acid blood level-
dc.subjectglucose homeostasis-
dc.subjectglucose utilization-
dc.subjectglycogen analysis-
dc.subjectglycogen liver level-
dc.subjectinsulin resistance-
dc.subjectinsulin sensitivity-
dc.subjectintravenous glucose tolerance test-
dc.subjectlipid analysis-
dc.subjectliver function-
dc.subjectmale-
dc.subjectmetabolic parameters-
dc.subjectnonhuman-
dc.subjectprotein content-
dc.subjectprotein folding-
dc.subjectprotein phosphorylation-
dc.subjectrat-
dc.subject1-Phosphatidylinositol 3-Kinase-
dc.subjectAlcohol Drinking-
dc.subjectAnimals-
dc.subjectBlotting, Northern-
dc.subjectBlotting, Western-
dc.subjectBody Weight-
dc.subjectCholesterol-
dc.subjectEating-
dc.subjectEthanol-
dc.subjectFatty Acids, Nonesterified-
dc.subjectGene Expression-
dc.subjectGlucose Transporter Type 2-
dc.subjectGlycogen-
dc.subjectInsulin-
dc.subjectInsulin Resistance-
dc.subjectIntracellular Signaling Peptides and Proteins-
dc.subjectLipoproteins-
dc.subjectLiver-
dc.subjectMale-
dc.subjectMonosaccharide Transport Proteins-
dc.subjectPhosphoproteins-
dc.subjectPhosphorylation-
dc.subjectProtein-Serine-Threonine Kinases-
dc.subjectProto-Oncogene Proteins-
dc.subjectProto-Oncogene Proteins c-akt-
dc.subjectRats-
dc.subjectRats, Wistar-
dc.subjectReceptor, Insulin-
dc.subjectTriglycerides-
dc.subjectAnimalia-
dc.subjectRattus norvegicus-
dc.titleLow ethanol consumption induces enhancement of insulin sensitivity in liver of normal ratsen
dc.typeoutro-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationDept. of Physiology and Biophysics Institute of Biomedical Sciences University of Sao Paulo, Av. Prof. Lineu Prestes 1524, 05508-900, Sao Paulo-
dc.description.affiliationDepartment of Marine Biology and Coastal Management University of the State of Sao Paulo, Praça Infante Dom Henrique, 11330-900, Sao Vicente-
dc.identifier.doi10.1016/j.lfs.2004.12.046-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofLife Sciences-
dc.identifier.scopus2-s2.0-23044479330-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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