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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/68403
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dc.contributor.authorPaiva, Sergio Alberto Rupp de-
dc.contributor.authorNovo, Rosangela-
dc.contributor.authorMatsubara, Beatriz Bojikian-
dc.contributor.authorMatsubara, Luiz Shiguero-
dc.contributor.authorGaiolla, Paula Schmidt Azevedo-
dc.contributor.authorMinicucci, Marcos Ferreira-
dc.contributor.authorCampana, Álvaro O.-
dc.contributor.authorZornoff, Leonardo Antonio Mamede-
dc.date.accessioned2014-05-27T11:21:37Z-
dc.date.accessioned2016-10-25T18:21:06Z-
dc.date.available2014-05-27T11:21:37Z-
dc.date.available2016-10-25T18:21:06Z-
dc.date.issued2005-09-01-
dc.identifierhttp://jn.nutrition.org/content/135/9/2109.long-
dc.identifier.citationJournal of Nutrition, v. 135, n. 9, p. 2109-2113, 2005.-
dc.identifier.issn0022-3166-
dc.identifier.urihttp://hdl.handle.net/11449/68403-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/68403-
dc.description.abstractThe objective of this study was to investigate the effects of exposure to tobacco smoke (ETS) in rats that were or were not supplemented with dietary β-carotene (BC), on ventricular remodeling and survival after myocardial infarction (Ml). Rats (n = 189) were allocated to 4 groups: the control group, n = 45; group BC administered 500 mg/kg diet, n = 49, BC supplemented rats; group ETS, n - 55, rats exposed to tobacco smoke; and group BC+ETS, n = 40. Wistar rats weighing 10O g were administered one of the treatments until they weighed 200 to 250 g (∼5 wk). The ETS rats were exposed to cigarette smoke for 30 min 4 times/d, in a chamber connected to a smoking device. After reaching a weight of 200-250 g, rats were subjected to experimental MI (coronary artery occlusion) and mortality rates were determined over the next 105 d. In addition, echocardiographic, isolated heart, morphometrical, and biochemical studies were performed. Mortality data were tested using Kaplan-Meyer curves and other data by 2-way ANOVA. Survival rates were greater in the ETS group (58.2%) than in the control (33.3%) (P = 0.001) and BC+ETS rats (30.0%) (P = 0.007). The groups did not differ in the other comparisons. Left ventricular end-diastolic diameter normalized to body weight was greater and maximal systolic pressures were lower in the ETS groups than in non-ETS groups. Previous exposure to tobacco smoke induced a process of cardiac remodeling after MI. There is a paradoxical protector effect with tobacco smoke exposure, characterized by lower mortality, which is offset by BC supplementation. © 2005 American Society for Nutritional Sciences.en
dc.format.extent2109-2113-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectβ-carotene-
dc.subjectMyocardial infarction-
dc.subjectParadoxical effect-
dc.subjectSmoking-
dc.subjectVentricular remodeling-
dc.subjectbeta carotene-
dc.subjectcigarette smoke-
dc.subjecttobacco smoke-
dc.subjectanalysis of variance-
dc.subjectanimal experiment-
dc.subjectanimal model-
dc.subjectanimal tissue-
dc.subjectbody weight-
dc.subjectcontrolled study-
dc.subjectdisease model-
dc.subjectechocardiography-
dc.subjectheart infarction-
dc.subjectheart left ventricle enddiastolic volume-
dc.subjectheart protection-
dc.subjectimage analysis-
dc.subjectisolated heart-
dc.subjectKaplan Meier method-
dc.subjectmale-
dc.subjectmorphometrics-
dc.subjectmortality-
dc.subjectnonhuman-
dc.subjectrat-
dc.subjectrat strain-
dc.subjectsmoking-
dc.subjectsurvival rate-
dc.subjectsystolic blood pressure-
dc.subjectAnimals-
dc.subjectbeta Carotene-
dc.subjectDiet-
dc.subjectEchocardiography-
dc.subjectHeart-
dc.subjectMale-
dc.subjectMyocardial Infarction-
dc.subjectMyocardium-
dc.subjectRats-
dc.subjectRats, Wistar-
dc.subjectSmoke-
dc.subjectSurvival Analysis-
dc.subjectTobacco-
dc.subjectVentricular Remodeling-
dc.subjectNicotiana tabacum-
dc.subjectRattus norvegicus-
dc.titleβ-carotene attenuates the paradoxical effect of tobacco smoke on the mortality of rats after experimental myocardial infarctionen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationDepartamento de Clinica Médica Faculdade de Medicina de Botucatu Universidade Estadual Paulista (UNESP), Botucatu-
dc.description.affiliationUnespDepartamento de Clinica Médica Faculdade de Medicina de Botucatu Universidade Estadual Paulista (UNESP), Botucatu-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofJournal of Nutrition-
dc.identifier.scopus2-s2.0-24744463574-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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