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dc.contributor.authorSpínola, Paulo Galvão-
dc.contributor.authorBagnoli, Vicente Renato-
dc.contributor.authorFernandes, César Eduardo-
dc.identifier.citationRevista Brasileira de Medicina, v. 62, n. 11, p. 492-497, 2005.-
dc.description.abstractIntroduction: Hypercholesterolemia is an important risk factor for cardiovascular disease, the first cause of death and third reason for hospital admissions in Brazil. The reduction of serum cholesterol levels reduces morbidity and mortality from cardiovascular disease. The present study evaluated the efficacy and safety of atorvastatin in the treatment of Brazilian patients with primary hypercholesterolemia (types IIA and IIB dyslipidemias). Patients and methods: After a 4-week wash-out period, 152 patients were treated with atorvastatin at the initial dose of 10 mg/day. According to treatment efficacy within the first 8 weeks this dose could be increased to 20 mg/day. Treatment lasted for a total of 16 weeks, and its efficacy was evaluated by the reduction of serum levels of LDL-cholesterol, total cholesterol, HDL-cholesterol, and triglycerides, as well as by the propotion of patients that achieved the target levels recommended by the National Cholesterol Education Program - Adult Treatment Panel II (NCEP ATP II) Results: The analysis of efficacy was conducted in 145 patients. Atorvastatin led to significant reductions in the levels of LDL-cholesterol after 8 and 16 weeks of treatment (P<0.001 for both comparisons). The relative reduction of such levels was 38% (P<0.001 after 8 and 16 weeks). Atorvastatin also led to significant reductions of total cholesterol and triglycerides. At the end of the study, 81% of patients achieved the target LDL-cholesterol levels recommended by NCEP ATP II. Treatment was well tolerated, and was interrupted due to creatine phosphokinase elevation in only one patient. Conclusion: Atorvastatina is efficacious and safe in the treatment of patients with primary hypercholesteromia. © Copyright Moreira Jr. Editora. Todos os direitos reservados.en
dc.subjectHydroxymethylglutaryl CoA reductase inhibitors-
dc.subjectHypercholesterolemia; hyperlipidemia-
dc.subjectcreatine kinase-
dc.subjectlow density lipoprotein cholesterol-
dc.subjectabnormally high substrate concentration in blood-
dc.subjectcholesterol blood level-
dc.subjectclinical trial-
dc.subjectcomparative study-
dc.subjectcontrolled clinical trial-
dc.subjectcontrolled study-
dc.subjectcreatine kinase blood level-
dc.subjectdose time effect relation-
dc.subjectdrug dose regimen-
dc.subjectdrug efficacy-
dc.subjectdrug safety-
dc.subjectdrug tolerability-
dc.subjecthealth education-
dc.subjecthealth program-
dc.subjectmajor clinical study-
dc.subjectstatistical significance-
dc.subjecttreatment outcome-
dc.subjecttriacylglycerol blood level-
dc.titleEficácia e segurança da atorvastatina no tratamento de pacientes com hipercolesterolemia primáriapt
dc.title.alternativeSafety and efficacy of atorvastatin in the treatment of patients with primary hypercholesterolemiaen
dc.contributor.institutionUniversidade Federal da Bahia (UFBA)-
dc.contributor.institutionUniversidade Federal do Rio Grande do Norte (UFRN)-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionFaculdade de Medicina do ABC (FMABC)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionCEPRH - Centro de Pesquisa e Assistência em Reprodução Humana-
dc.description.affiliationDepartamento de Ginecologia, Obstetrícia e Reprodução Humana Faculdade de Medicina UFBA-
dc.description.affiliationMaternidade Climério de Oliveira - UFBA-
dc.description.affiliationTocoginecologia da UFRN-
dc.description.affiliationCentro de Pesquisa em Reproducao Humana da Organizacao Mundial da Saude Maternidade Climério de Oliveira-UFBA-
dc.description.affiliationDepartamento de Ginecologia e Obstetrícia Faculdade de Medicina Universidade de São Paulo-
dc.description.affiliationClínica Ginecologica da Disciplina de Ginecologia e Obstetrícia Faculdade de Medicina do ABC, São Paulo-
dc.description.affiliationPós-Graduação em Ginecologia, Obstetrícia e Mastologia Faculdade de Medicina de Botucatu UNESP, São Paulo-
dc.description.affiliationCEPRH - Centro de Pesquisa e Assistência em Reprodução Humana, Rua Caetano Moura, 35, CEP 40210-341 - Salvador - BA-
dc.description.affiliationUnespPós-Graduação em Ginecologia, Obstetrícia e Mastologia Faculdade de Medicina de Botucatu UNESP, São Paulo-
dc.rights.accessRightsAcesso aberto-
dc.relation.ispartofRevista Brasileira de Medicina-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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