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dc.contributor.authorBarboza-Filho, Carlos G.-
dc.contributor.authorCabrera, Flavio C.-
dc.contributor.authorDos Santos, Renivaldo J.-
dc.contributor.authorDe Saja Saez, Jose Antonio-
dc.contributor.authorJob, Aldo Eloizo-
dc.identifier.citationExperimental Parasitology. San Diego: Academic Press Inc. Elsevier B.V., v. 130, n. 2, p. 152-158, 2012.-
dc.description.abstractThe development of nanotechnology has generated new means of disease diagnosis and treatment. Infectious diseases, including leishmaniasis, malaria, etc., have benefited from the advent of new nanomaterials and/or nanodevices capable of detecting specific antigens and antibodies with high specificity and low cost. In this paper, we present an investigation on a single-celled protozoan Leishmaniasis parasite, a disease considered of standard infectivity, given the high degree of immunological specificity. Natural rubber (NR) membranes incorporating gold nanoparticles (GNPs) were placed in the culture medium and the physiological behavior of Leishmania brasiliensis promastigotes was evaluated. The natural rubber membranes containing GNPs decreased the population growth rate, showing a lower index of living promastigotes (attached to the membrane surface) depending on the amount of nanoparticles deposited in the membrane surface. Such membranes may be used to develop a flexible band-aid for skin lesions from degenerative infection state, inhibiting the population growth of parasites in the lesions. In addition, natural rubber membranes would also stimulate angiogenesis in damaged tissues. (C) 2011 Elsevier B.V. All rights reserved.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.description.sponsorshipINEO groups-
dc.publisherAcademic Press Inc. Elsevier B.V.-
dc.sourceWeb of Science-
dc.subjectGold nanoparticlesen
dc.subjectNatural rubberen
dc.subjectLeishmania brasiliensisen
dc.titleThe influence of natural rubber/Au nanoparticle membranes on the physiology of Leishmania brasiliensisen
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniv Valladolid-
dc.description.affiliationUNESP, Dept Fis Quim & Biol, Fac Ciencias & Tecnol, BR-19060080 Presidente Prudente, SP, Brazil-
dc.description.affiliationUniv Valladolid, Fac Ciencias, E-47011 Valladolid, Spain-
dc.description.affiliationUnespUNESP, Dept Fis Quim & Biol, Fac Ciencias & Tecnol, BR-19060080 Presidente Prudente, SP, Brazil-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofExperimental Parasitology-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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