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http://acervodigital.unesp.br/handle/11449/68750
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DC Field | Value | Language |
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dc.contributor.author | De Lima, Andréa Cristina | - |
dc.contributor.author | Michelin, Daniele Carvalho | - |
dc.contributor.author | Santos, Manoel Roberta Da Cruz | - |
dc.contributor.author | Paganelli, Maria Ondina | - |
dc.contributor.author | Ignácio, Rosa Fernanda | - |
dc.contributor.author | Chaud, Marco Vinícius | - |
dc.date.accessioned | 2014-05-27T11:21:48Z | - |
dc.date.accessioned | 2016-10-25T18:21:53Z | - |
dc.date.available | 2014-05-27T11:21:48Z | - |
dc.date.available | 2016-10-25T18:21:53Z | - |
dc.date.issued | 2006-01-01 | - |
dc.identifier | http://www.latamjpharm.org/trabajos/25/1/LAJOP_25_1_2_3_M2PJ125R5P.pdf | - |
dc.identifier.citation | Acta Farmaceutica Bonaerense, v. 25, n. 1, p. 104-107, 2006. | - |
dc.identifier.issn | 0326-2383 | - |
dc.identifier.uri | http://hdl.handle.net/11449/68750 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/68750 | - |
dc.description.abstract | The aim of this work was to evaluate the influence of compression force and humidity in the dissolution profile of tablets formulation. As hidroclorotyiazide presents real problems of bioavailability, it was incorporate as standard drug in a formulation of tablets to study the mechanical resistance, time of disintegration and dissolution profile in function of humidity and compression force. The time of disintegration was not affected by the compression force, but it was influenced by humidity. The dissolution profile was altered by the compression force and for the humidity as well. Both factors can alter the bioavailability of drugs dispensed in the form of tablets. | en |
dc.format.extent | 104-107 | - |
dc.language.iso | por | - |
dc.source | Scopus | - |
dc.subject | Disintegration | - |
dc.subject | Dissolution profile | - |
dc.subject | Tablets | - |
dc.subject | hydrochlorothiazide | - |
dc.subject | compressive strength | - |
dc.subject | dissolution | - |
dc.subject | drug bioavailability | - |
dc.subject | force | - |
dc.subject | humidity | - |
dc.subject | tablet formulation | - |
dc.title | Força de compressão e umidade no perfil de dissolução da hidroclorotiazida | pt |
dc.title.alternative | Compression force and humidity in the dissolution profile of hidroclorotyazide | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | Faculdade de Ciências da Saúde Curso de Farmácia | - |
dc.description.affiliation | Universidade Estadual Paulista (UNESP) Faculdade de Ciências Farmacêuticas Departamento de Fármacos e Medicamentos, Rodovia Araraquara - Jau, km 1, 14801-902, Araraquara - Sao Paulo | - |
dc.description.affiliation | Universidade Metodista de Piracicaba (UNIMEP) Faculdade de Ciências da Saúde Curso de Farmácia, Rodovia do Acucar, km 157, 13400-911, Piracicaba - Sao Paulo | - |
dc.description.affiliationUnesp | Universidade Estadual Paulista (UNESP) Faculdade de Ciências Farmacêuticas Departamento de Fármacos e Medicamentos, Rodovia Araraquara - Jau, km 1, 14801-902, Araraquara - Sao Paulo | - |
dc.rights.accessRights | Acesso aberto | - |
dc.relation.ispartof | Acta Farmaceutica Bonaerense | - |
dc.identifier.scopus | 2-s2.0-33744470123 | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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