You are in the accessibility menu

Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorDias, Ana Carolina Rodrigues-
dc.contributor.authorColombari, Eduardo-
dc.identifier.citationAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology, v. 290, n. 5, 2006.-
dc.description.abstractMicroinjection of S-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) in the nucleus of the solitary tract (NTS) of conscious rats causes hypertension, bradycardia, and vasoconstriction in the renal, mesenteric, and hindquarter vascular beds. In the hindquarter, the initial vasoconstriction is followed by vasodilation with AMPA doses >5 pmol/100 nl. To test the hypothesis that this vasodilation is caused by activation of a nitroxidergic pathway in the NTS, we examined the effect of pretreatment with the nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester (L-NAME, 10 nmol/100 nl, microinjected into the NTS) on changes in mean arterial pressure, heart rate, and regional vascular conductance (VC) induced by microinjection of AMPA (10 pmol/100 nl in the NTS) in conscious rats. AMPA increased hindquarter VC by 18 ± 4%, but after pretreatment with L-NAME, AMPA reduced hindquarter VC by 16 ± 7% and 17 ± 9% (5 and 15 min after pretreatment, P < 0.05 compared with before pretreatment). Pretreatment with L-NAME reduced AMPA-induced bradycardia from 122 ± 40 to 92 ± 32 beats/min but did not alter the hypertension induced by AMPA (35 ± 5 mmHg before pretreatment, 43 ± 6 mmHg after pretreatment). Control injections with D-NAME did not affect resting values or the response to AMPA. The present study shows that stimulation of AMPA receptors in the NTS activates both vasodilatatory and vasoconstrictor mechanisms and that the vasodilatatory mechanism depends on production of nitric oxide in the NTS. Copyright © 2006 the American Physiological Society.en
dc.subjectCardiovascular regulation-
dc.subjectNitric oxide synthase-
dc.subjectRegional vascular conductance-
dc.subjectalpha amino 3 hydroxy 5 methyl 4 isoxazolepropionic acid-
dc.subjectAMPA receptor-
dc.subjectn(g) nitroarginine methyl ester-
dc.subjectnitric oxide-
dc.subjectanimal experiment-
dc.subjectanimal model-
dc.subjectcardiovascular parameters-
dc.subjectcontrolled study-
dc.subjectheart rate-
dc.subjectmean arterial pressure-
dc.subjectpriority journal-
dc.subjectsolitary tract nucleus-
dc.subjectBlood Pressure-
dc.subjectBrain Stem-
dc.subjectData Interpretation, Statistical-
dc.subjectEnzyme Inhibitors-
dc.subjectHeart Rate-
dc.subjectHemodynamic Processes-
dc.subjectNitric Oxide-
dc.subjectNitric Oxide Synthase Type I-
dc.subjectRats, Wistar-
dc.subjectReceptors, AMPA-
dc.subjectRegional Blood Flow-
dc.subjectSolitary Nucleus-
dc.titleCentral nitric oxide modulates hindquarter vasodilation elicited by AMPA receptor stimulation in the NTS of conscious ratsen
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationDepartment of Physiology Universidade Federal de São Paulo-Escola Paulista de Medicina, São Paulo-
dc.description.affiliationDepartment of Pathology and Physiology Universidade Estadual de São Paulo, Araraquara-
dc.description.affiliationDept. of Physiology Universidade Federal de São Paulo-EPM, 862 Botucatu St., São Paulo SP 04023-60-
dc.description.affiliationUnespDepartment of Pathology and Physiology Universidade Estadual de São Paulo, Araraquara-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofAmerican Journal of Physiology: Regulatory Integrative and Comparative Physiology-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.