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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/69055
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dc.contributor.authorLira, Simone P.-
dc.contributor.authorVita-Marques, Aline M.-
dc.contributor.authorSeleghim, Mirna H. R.-
dc.contributor.authorBugni, Tim S.-
dc.contributor.authorLaBarbera, Daniel V.-
dc.contributor.authorSette, Lara D.-
dc.contributor.authorSponchiado, Sandra Regina Pombeiro-
dc.contributor.authorIreland, Chris M.-
dc.contributor.authorBerlinck, Roberto G. S.-
dc.date.accessioned2014-05-27T11:21:57Z-
dc.date.accessioned2016-10-25T18:22:36Z-
dc.date.available2014-05-27T11:21:57Z-
dc.date.available2016-10-25T18:22:36Z-
dc.date.issued2006-09-01-
dc.identifierhttp://dx.doi.org/10.1038/ja.2006.76-
dc.identifier.citationJournal of Antibiotics, v. 59, n. 9, p. 553-563, 2006.-
dc.identifier.issn0021-8820-
dc.identifier.urihttp://hdl.handle.net/11449/69055-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/69055-
dc.description.abstractChemical investigation of the cytotoxic and anti-tuberculosis active butanone extract obtained from the growth media of the marine-derived fungus Beauveria felina led to the isolation of two new destruxins, [β-MePro] destruxin E chlorohydrin (1) and pseudodestruxin C (3), along with five known cyclic depsipeptides. The structures of the new destruxin derivatives were established by analysis of spectroscopic data, while the absolute configuration of the common amino acid residues was established by Marfey's analysis. The absolute configuration of the 2(A),4(5)-5-chloro-2,4-dihydroxypentanoic acid residue in 1 could be established by application of a J-based configuration method followed by derivatization with R-MPA-Cl and NMR analysis. © Japan Antibiotics Research Association.en
dc.format.extent553-563-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectBeauveria felina-
dc.subjectDestruxins-
dc.subjectFungi-
dc.subjectMarine microorganisms-
dc.subject2,4 5 chloro 2,4 dihydroxypentanoic acid-
dc.subjectbeta methylprolyldestruxin e chlorohydrin-
dc.subjectcyclodepsipeptide-
dc.subjectdestruxin-
dc.subjectdestruxin e chlorohydrin-
dc.subjectisariin b-
dc.subjectphenylalanyl, n methylvalyldestruxin b-
dc.subjectpseudodestruxin c-
dc.subjectroseocardin-
dc.subjectroseotoxin b-
dc.subjectunclassified drug-
dc.subjectvaleric acid derivative-
dc.subjectanimal cell-
dc.subjectantibacterial activity-
dc.subjectBeauveria-
dc.subjectcancer cell culture-
dc.subjectcontrolled study-
dc.subjectcytotoxicity-
dc.subjectderivatization-
dc.subjectdrug isolation-
dc.subjectfungus-
dc.subjecthigh performance liquid chromatography-
dc.subjecthuman-
dc.subjecthuman cell-
dc.subjecthydrolysis-
dc.subjectmouse-
dc.subjectnonhuman-
dc.subjectpriority journal-
dc.subjectproton nuclear magnetic resonance-
dc.subjectspectroscopy-
dc.subjectstereochemistry-
dc.subjectAmino Acids-
dc.subjectAnimals-
dc.subjectAntibiotics, Antineoplastic-
dc.subjectAntibiotics, Antitubercular-
dc.subjectCell Line, Tumor-
dc.subjectDepsipeptides-
dc.subjectFungal Proteins-
dc.subjectHumans-
dc.subjectMice-
dc.subjectMolecular Structure-
dc.subjectMycobacterium tuberculosis-
dc.subjectMycotoxins-
dc.subjectSpectrum Analysis-
dc.titleNew destruxins from the marine-derived fungus Beauveria felinaen
dc.typeoutro-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversity of Utah-
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationInstituto de Química de São Carlos Universidade de São Paulo, CP 780, CEP 13560-970, São Carlos, SP-
dc.description.affiliationDepartment of Medicinal Chemistry University of Utah, Salt Lake City, UT 84112-
dc.description.affiliationDivisão de Recursos Microbianos Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas Universidade Estadual de Campinas, CP 6171, 13083-970, Campinas, SP-
dc.description.affiliationDepartamento de Bioquímica e Tecnologia Química Universidade Estadual Paulista, Araraquara, SP-
dc.description.affiliationUnespDepartamento de Bioquímica e Tecnologia Química Universidade Estadual Paulista, Araraquara, SP-
dc.identifier.doi10.1038/ja.2006.76-
dc.identifier.wosWOS:000241312900004-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofJournal of Antibiotics-
dc.identifier.scopus2-s2.0-33751253424-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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