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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/69093
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dc.contributor.authorda Silva, Aline Loureno̧-
dc.contributor.authorRibeiro, Lucilene Arilho-
dc.contributor.authorCooper, Margaret E.-
dc.contributor.authorMarazita, Mary L.-
dc.contributor.authorMoretti-Ferreira, Danilo-
dc.date.accessioned2014-05-27T11:21:58Z-
dc.date.accessioned2016-10-25T18:22:40Z-
dc.date.available2014-05-27T11:21:58Z-
dc.date.available2016-10-25T18:22:40Z-
dc.date.issued2006-09-20-
dc.identifierhttp://dx.doi.org/10.1590/S1415-47572006000300005-
dc.identifier.citationGenetics and Molecular Biology, v. 29, n. 3, p. 439-442, 2006.-
dc.identifier.issn1415-4757-
dc.identifier.issn1678-4685-
dc.identifier.urihttp://hdl.handle.net/11449/69093-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/69093-
dc.description.abstractCleft lip and/or palate (CL/P) is a major congenital defect with complex etiology, including multiple genetic and environmental factors. Approximately two thirds of the cases are not accompanied by other anomalies and are called nonsyndromic (NS). In the present study, we performed transmission distortion analysis of the MSX1-CA, TGFB3-CA and MTHFR-C677T polymorphisms in 60 parent-child triads, in which the NS-CL/ P affected child had at least one affected parent. No association with genes MSX1 or TGFB3 was found, but the results were suggestive of an association of the MTHFR-C677T polymorphism with NS-CL/P. © 2006 Sociedade Brasileira de Genética.en
dc.format.extent439-442-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectCleft lip-
dc.subjectCleft palate-
dc.subjectOral clefts-
dc.subject5,10 methylenetetrahydrofolate reductase (FADH2)-
dc.subjectDNA-
dc.subjecttranscription factor MSX1-
dc.subjecttransforming growth factor beta3-
dc.subjectadult-
dc.subjectallele-
dc.subjectchild-
dc.subjectcleft lip-
dc.subjectcleft palate-
dc.subjectDNA determination-
dc.subjectfamily assessment-
dc.subjectfemale-
dc.subjectgene frequency-
dc.subjectgene linkage disequilibrium-
dc.subjectgene mapping-
dc.subjectgenetic association-
dc.subjectgenetic polymorphism-
dc.subjectgenetic risk-
dc.subjectgenotype-
dc.subjectheredity-
dc.subjecthuman-
dc.subjectmajor clinical study-
dc.subjectmale-
dc.subjectpathophysiology-
dc.subjectrisk assessment-
dc.subjectsex difference-
dc.titleTransmission analysis of candidate genes for nonsyndromic oral clefts in Brazilian parent-child triads with recurrenceen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversity of Pittsburgh-
dc.description.affiliationUniversidade Estadual Paulista - UNESP, Distrito de Rubiao Junior s/n, 18618-000 Botucatu SP-
dc.description.affiliationHospital de Reabilitatiao de Anomalias Craniofaciais Universidade de São Paulo - USP, Bauru, SP-
dc.description.affiliationCenter for Craniofacial and Dental Genetics University of Pittsburgh, Pittsburgh, PA-
dc.description.affiliationUnespUniversidade Estadual Paulista - UNESP, Distrito de Rubiao Junior s/n, 18618-000 Botucatu SP-
dc.identifier.doi10.1590/S1415-47572006000300005-
dc.identifier.scieloS1415-47572006000300005-
dc.identifier.wosWOS:000240328500005-
dc.rights.accessRightsAcesso aberto-
dc.identifier.file2-s2.0-33748650083.pdf-
dc.relation.ispartofGenetics and Molecular Biology-
dc.identifier.scopus2-s2.0-33748650083-
dc.identifier.orcid0000-0002-9256-7623pt
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