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http://acervodigital.unesp.br/handle/11449/69198
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DC Field | Value | Language |
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dc.contributor.author | Blau, Lorena | - |
dc.contributor.author | Menegon, Renato Farina | - |
dc.contributor.author | Chin, Chung Man | - |
dc.date.accessioned | 2014-05-27T11:22:01Z | - |
dc.date.accessioned | 2016-10-25T18:22:54Z | - |
dc.date.available | 2014-05-27T11:22:01Z | - |
dc.date.available | 2016-10-25T18:22:54Z | - |
dc.date.issued | 2006-11-01 | - |
dc.identifier | http://dx.doi.org/10.1590/S0100-40422006000600028 | - |
dc.identifier.citation | Quimica Nova, v. 29, n. 6, p. 1307-1316, 2006. | - |
dc.identifier.issn | 0100-4042 | - |
dc.identifier.issn | 1678-7064 | - |
dc.identifier.uri | http://hdl.handle.net/11449/69198 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/69198 | - |
dc.description.abstract | Strategies that promote selective activation of prodrugs by enzymes can be divided into two major classes: 1) deliver of a monoclonal antibody-enzyme immunoconjugate that can recognize a specific antigen and promote the prodrug to a citotoxic drug, with a high selectivity for the target cells, and 2) selective gene delivery encoding an enzyme that can promote the prodrug to a citotoxic drug for the target cells. In this article are discussed ADEPT (antibody-directed enzyme prodrug therapy), GDEPT (gene-directed enzyme prodrug therapy), VDEPT (virus-directed enzyme prodrug therapy), GPAT (genetic prodrug activation therapy) and PDEPT (polymer-directed enzyme prodrug therapy) approaches, their clinical trials, advantages, disadvantages and perspectives. | en |
dc.format.extent | 1307-1316 | - |
dc.language.iso | por | - |
dc.source | Scopus | - |
dc.subject | Cancer | - |
dc.subject | Enzymes | - |
dc.subject | Prodrugs | - |
dc.title | Pró-fármaco ativado por enzima, uma estratégia promissora na quimioterapia | pt |
dc.title.alternative | Prodrug activation by enzyme, a promising strategy for chemotherapy | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | Departamento de Fármacos e Medicamentos Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista Júlio de Mesquita Filho, CP 502, 14801-902 Araraquara - SP | - |
dc.description.affiliationUnesp | Departamento de Fármacos e Medicamentos Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista Júlio de Mesquita Filho, CP 502, 14801-902 Araraquara - SP | - |
dc.identifier.doi | 10.1590/S0100-40422006000600028 | - |
dc.identifier.scielo | S0100-40422006000600028 | - |
dc.identifier.wos | WOS:000242341600028 | - |
dc.rights.accessRights | Acesso aberto | - |
dc.identifier.file | 2-s2.0-33845716527.pdf | - |
dc.relation.ispartof | Química Nova | - |
dc.identifier.scopus | 2-s2.0-33845716527 | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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