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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/69198
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dc.contributor.authorBlau, Lorena-
dc.contributor.authorMenegon, Renato Farina-
dc.contributor.authorChin, Chung Man-
dc.date.accessioned2014-05-27T11:22:01Z-
dc.date.accessioned2016-10-25T18:22:54Z-
dc.date.available2014-05-27T11:22:01Z-
dc.date.available2016-10-25T18:22:54Z-
dc.date.issued2006-11-01-
dc.identifierhttp://dx.doi.org/10.1590/S0100-40422006000600028-
dc.identifier.citationQuimica Nova, v. 29, n. 6, p. 1307-1316, 2006.-
dc.identifier.issn0100-4042-
dc.identifier.issn1678-7064-
dc.identifier.urihttp://hdl.handle.net/11449/69198-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/69198-
dc.description.abstractStrategies that promote selective activation of prodrugs by enzymes can be divided into two major classes: 1) deliver of a monoclonal antibody-enzyme immunoconjugate that can recognize a specific antigen and promote the prodrug to a citotoxic drug, with a high selectivity for the target cells, and 2) selective gene delivery encoding an enzyme that can promote the prodrug to a citotoxic drug for the target cells. In this article are discussed ADEPT (antibody-directed enzyme prodrug therapy), GDEPT (gene-directed enzyme prodrug therapy), VDEPT (virus-directed enzyme prodrug therapy), GPAT (genetic prodrug activation therapy) and PDEPT (polymer-directed enzyme prodrug therapy) approaches, their clinical trials, advantages, disadvantages and perspectives.en
dc.format.extent1307-1316-
dc.language.isopor-
dc.sourceScopus-
dc.subjectCancer-
dc.subjectEnzymes-
dc.subjectProdrugs-
dc.titlePró-fármaco ativado por enzima, uma estratégia promissora na quimioterapiapt
dc.title.alternativeProdrug activation by enzyme, a promising strategy for chemotherapyen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationDepartamento de Fármacos e Medicamentos Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista Júlio de Mesquita Filho, CP 502, 14801-902 Araraquara - SP-
dc.description.affiliationUnespDepartamento de Fármacos e Medicamentos Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista Júlio de Mesquita Filho, CP 502, 14801-902 Araraquara - SP-
dc.identifier.doi10.1590/S0100-40422006000600028-
dc.identifier.scieloS0100-40422006000600028-
dc.identifier.wosWOS:000242341600028-
dc.rights.accessRightsAcesso aberto-
dc.identifier.file2-s2.0-33845716527.pdf-
dc.relation.ispartofQuímica Nova-
dc.identifier.scopus2-s2.0-33845716527-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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