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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/69295
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dc.contributor.authorAnbinder, Ana Lia-
dc.contributor.authorJunqueira, Juliana Campos-
dc.contributor.authorMancini, Maria Nadir G.-
dc.contributor.authorBalducci, Ivan-
dc.contributor.authorRocha, Rosilene Fernandes da-
dc.contributor.authorCarvalho, Yasmin Rodarte-
dc.date.accessioned2014-05-27T11:22:04Z-
dc.date.accessioned2016-10-25T18:23:06Z-
dc.date.available2014-05-27T11:22:04Z-
dc.date.available2016-10-25T18:23:06Z-
dc.date.issued2006-12-01-
dc.identifierhttp://dx.doi.org/10.1590/S0103-64402006000400001-
dc.identifier.citationBrazilian Dental Journal, v. 17, n. 4, p. 267-273, 2006.-
dc.identifier.issn0103-6440-
dc.identifier.issn1806-4760-
dc.identifier.urihttp://hdl.handle.net/11449/69295-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/69295-
dc.description.abstractThe purpose of this study was to evaluate the effects of simvastatin, by oral or subcutaneous administration, on tibial defects regeneration and blood cholesterol level in rats. A surgical defect was made on the right tibia of 40 male animals assigned to 4 groups (n=10), based on two routes of administration and on the use or not of simvastatin: subcutaneous injection of simvastatin (7 mg/kg) (group AT) or only the vehicle of drug suspension (group AC), above the defect area, for 5 days; and 20 mg/kg of simvastatin macerated on water (group BT) or only water (group BC), orally, daily, during the whole observation period. The animals were sacrificed after 15 or 30 days, when blood samples were analyzed to check plasma cholesterol levels. Tibiae were removed and, after decalcification and routine laboratorial processing, histological and histomorphometrical analyses were carried out. ANOVA was used for statistical analysis at 5% signficance level. The histological and histomorphometrical analyses showed significant differences only between the experimental periods (p<0.05). Animals sacrificed after 30 days showed better bone repair (p<0.05). There was no statistically significant difference (p>0.05) for blood cholesterol levels between the groups. In conclusion, simvastatin administration either orally or subcutaneously did not improve bone repair of experimental tibial defects and did not alter blood cholesterol levels in rats.en
dc.format.extent267-273-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectBone regeneration-
dc.subjectCholesterol-
dc.subjectRats-
dc.subjectSimvastatin-
dc.subjectcholesterol-
dc.subjectchromogenic substrate-
dc.subjectdiagnostic agent-
dc.subjecthypocholesterolemic agent-
dc.subjectsimvastatin-
dc.subjectanimal-
dc.subjectblood-
dc.subjectbone development-
dc.subjectbone disease-
dc.subjectbone regeneration-
dc.subjectbone remodeling-
dc.subjectdrug effect-
dc.subjectmale-
dc.subjectoral drug administration-
dc.subjectosteoblast-
dc.subjectosteocyte-
dc.subjectpathology-
dc.subjectperiosteum-
dc.subjectrat-
dc.subjectsubcutaneous drug administration-
dc.subjecttibia-
dc.subjecttime-
dc.subjectWistar rat-
dc.subjectAdministration, Oral-
dc.subjectAnimals-
dc.subjectAnticholesteremic Agents-
dc.subjectBone Diseases-
dc.subjectBone Regeneration-
dc.subjectBone Remodeling-
dc.subjectChromogenic Compounds-
dc.subjectInjections, Subcutaneous-
dc.subjectMale-
dc.subjectOsteoblasts-
dc.subjectOsteocytes-
dc.subjectOsteogenesis-
dc.subjectPeriosteum-
dc.subjectRats, Wistar-
dc.subjectTibia-
dc.subjectTime Factors-
dc.titleInfluence of simvastatin on bone regeneration of tibial defects and blood cholesterol level in ratsen
dc.typeoutro-
dc.contributor.institutionUniversidade de Taubaté (UNITAU)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationDepartment of Dentistry University of Taubaté, Taubaté, SP-
dc.description.affiliationDepartment of Biosciences and Oral Diagnosis, São José dos Campos, SP-
dc.description.affiliationDepartment of Social Dentistry and Pediatric Clinics School of Dentistry of São José dos Campos São Paulo State University, São José dos Campos, SP-
dc.description.affiliationUnespDepartment of Social Dentistry and Pediatric Clinics School of Dentistry of São José dos Campos São Paulo State University, São José dos Campos, SP-
dc.identifier.doi10.1590/S0103-64402006000400001-
dc.identifier.scieloS0103-64402006000400001-
dc.rights.accessRightsAcesso aberto-
dc.identifier.fileS0103-64402006000400001.pdf-
dc.relation.ispartofBrazilian Dental Journal-
dc.identifier.scopus2-s2.0-34047178532-
dc.identifier.orcid0000-0003-3930-4274pt
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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