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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/69512
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dc.contributor.authorTempone, André Gustavo-
dc.contributor.authorMelhem, Márcia de Souza Carvalho-
dc.contributor.authorPrado, Frederico Oliveira-
dc.contributor.authorMotoie, Gabriela-
dc.contributor.authorHiramoto, Roberto Mitsuyoshi-
dc.contributor.authorAntoniazzi, Marta Maria-
dc.contributor.authorHaddad, Celio Fernando Baptista-
dc.contributor.authorJared, Carlos-
dc.date.accessioned2014-05-27T11:22:24Z-
dc.date.accessioned2016-10-25T18:23:33Z-
dc.date.available2014-05-27T11:22:24Z-
dc.date.available2016-10-25T18:23:33Z-
dc.date.issued2007-01-10-
dc.identifierhttp://dx.doi.org/10.2174/157018007778992856-
dc.identifier.citationLetters in Drug Design and Discovery, v. 4, n. 1, p. 67-73, 2007.-
dc.identifier.issn1570-1808-
dc.identifier.urihttp://hdl.handle.net/11449/69512-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/69512-
dc.description.abstractThe antiparasitic and antifungal activities of nine amphibian skin secretions were studied in different in vitro models. Seven secretions presented a considerable antiprotozoan activity and one showed promising results against Candida sp. These results can be the basis for the development of new drugs, especially for neglected parasitic diseases. © 2007 Bentham Science Publishers Ltd.en
dc.format.extent67-73-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectAmphibians-
dc.subjectAntimicrobial-
dc.subjectLeishmania-
dc.subjectPeptides-
dc.subjectSecretions-
dc.subjectTrypanosoma-
dc.subjectamino acid oxidase-
dc.subjectamphibian protein-
dc.subjectantifungal agent-
dc.subjectantiparasitic agent-
dc.subjectbenznidazole-
dc.subjectmeglumine antimonate-
dc.subjectpentamidine-
dc.subjectpyrimethamine-
dc.subjectAmphibia-
dc.subjectanimal cell-
dc.subjectanimal experiment-
dc.subjectanimal model-
dc.subjectanimal tissue-
dc.subjectCandida-
dc.subjectcontrolled study-
dc.subjectdose response-
dc.subjectdrug design-
dc.subjectdrug effect-
dc.subjectdrug research-
dc.subjectenzyme activity-
dc.subjectgrowth inhibition-
dc.subjectmouse-
dc.subjectnonhuman-
dc.subjectpriority journal-
dc.subjectskin secretion-
dc.titleAmphibian secretions for drug discovery studies: A search for new antiparasitic and antifungal compoundsen
dc.typeoutro-
dc.contributor.institutionInstituto Adolfo Lutz (IAL)-
dc.contributor.institutionInstituto Butantan-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationLab. Toxinologia Aplicada Departamento de Parasitologia Instituto Adolfo Lutz, Av. Dr. Arnaldo 355, 8 andar, CEP 01246-000 São Paulo-
dc.description.affiliationLab. Biologia Celular Instituto Butantan, Av. Vital Brazil, 1500, CEP 05503-900 - São Paulo-
dc.description.affiliationDepartamento de Zoologia Instituto de Biociências UNESP, Av. 24 A, 1515, CEP 13.506-900 - Rio Claro, SP-
dc.description.affiliationUnespDepartamento de Zoologia Instituto de Biociências UNESP, Av. 24 A, 1515, CEP 13.506-900 - Rio Claro, SP-
dc.identifier.doi10.2174/157018007778992856-
dc.identifier.wosWOS:000242910300012-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofLetters in Drug Design and Discovery-
dc.identifier.scopus2-s2.0-33845967153-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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