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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/69639
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dc.contributor.authorRusso-Carbolante, Elisa Maria de Sousa-
dc.contributor.authorPenteado, Flora Cristina Lobo-
dc.contributor.authorMedeiros, Luciene-
dc.contributor.authorKashima, Simone-
dc.contributor.authorTakayanagui, Oswaldo M.-
dc.contributor.authorCovas, Dimas Tadeu-
dc.date.accessioned2014-05-27T11:22:27Z-
dc.date.accessioned2016-10-25T18:23:49Z-
dc.date.available2014-05-27T11:22:27Z-
dc.date.available2016-10-25T18:23:49Z-
dc.date.issued2007-05-01-
dc.identifierhttp://dx.doi.org/10.1590/S0037-86822007000300005-
dc.identifier.citationRevista da Sociedade Brasileira de Medicina Tropical, v. 40, n. 3, p. 277-281, 2007.-
dc.identifier.issn0037-8682-
dc.identifier.urihttp://hdl.handle.net/11449/69639-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/69639-
dc.description.abstractHTLV-1 is the virus that causes T cell lymphoma/leukemia in adults and a neurological disorder known as HTLV-associated myelopathy or tropical spastic paraparesis. One of the transmission means is through contaminated blood and its byproducts. Because of the risk of HTLV-associated infections, screening for HTLV was introduced for Brazilian blood donors in 1993. Most of the diagnostic kits used in the national blood banks are bought from foreign companies. Brazil does not have the technology to produce this material and there is a need to produce diagnostic systems with national technology. In this study, we show the expression of gp21/HTLV-1 in Escherichia coli and its reactivity towards monoclonal antibodies and the antibodies of infected patients. Expressing these proteins is the first step towards obtaining diagnostic kits with Brazilian biotechnology.en
dc.format.extent277-281-
dc.language.isopor-
dc.sourceScopus-
dc.subjectgp21-
dc.subjectHeterologous expression-
dc.subjectHTLV-1-
dc.subjectRecombinant proteins-
dc.subjectmembrane protein-
dc.subjectmonoclonal antibody-
dc.subjectvirus antibody-
dc.subjectvirus glycoprotein-
dc.subjectantigen antibody reaction-
dc.subjectbiotechnology-
dc.subjectdiagnostic kit-
dc.subjectEscherichia coli-
dc.subjectHuman T cell leukemia virus 1-
dc.subjectmolecular cloning-
dc.subjectprokaryote-
dc.subjectprotein expression-
dc.subjectvirus diagnosis-
dc.subjectAntibodies, Monoclonal-
dc.subjectCloning, Molecular-
dc.subjectenv Gene Products, Human Immunodeficiency Virus-
dc.subjectGene Expression-
dc.subjectGene Products, env-
dc.subjectGenetic Vectors-
dc.subjectHTLV-I Antibodies-
dc.subjectHuman T-lymphotropic virus 1-
dc.subjectHumans-
dc.subjectImmunoblotting-
dc.subjectPolymerase Chain Reaction-
dc.subjectProkaryota-
dc.titleClonagem e expressão da glicoproteína transmembrana do vírus linfotrópico de células T humanas em sistema procariotopt
dc.title.alternativeCloning and expression of the transmembranic glycoprotein from human T cell lymphotropic virus in a prokaryotic systemen
dc.typeoutro-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationCentro Regional de Hemoterapia Hospital Das Clínicas Universidade de São Paulo, Ribeirão Preto, SP-
dc.description.affiliationDepartamento de Análises Clínicas Faculdade de Ciências Farmacêuticas Júlio de Mesquita Filho Universidade Estadual Paulista, Araraquara, SP-
dc.description.affiliationDepartamento de Neurologia Faculdade de Medicina de Ribeirão Preto Universidade de São Paulo, Ribeirão Preto, SP-
dc.description.affiliationDepartamento de Clínica Médica Faculdade de Medicina de Ribeirão Preto Universidade de São Paulo, Ribeirão Preto, SP-
dc.description.affiliationCentro Regional de Hemoterapia HCFMRP USP, R. Tenente Catão Roxo 2501, 14051-140 Ribeirão Preto, SP-
dc.description.affiliationUnespDepartamento de Análises Clínicas Faculdade de Ciências Farmacêuticas Júlio de Mesquita Filho Universidade Estadual Paulista, Araraquara, SP-
dc.identifier.doi10.1590/S0037-86822007000300005-
dc.identifier.scieloS0037-86822007000300005-
dc.identifier.wosWOS:000248032900005-
dc.rights.accessRightsAcesso aberto-
dc.identifier.file2-s2.0-34547161328.pdf-
dc.relation.ispartofRevista da Sociedade Brasileira de Medicina Tropical-
dc.identifier.scopus2-s2.0-34547161328-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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