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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/69732
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dc.contributor.authorDelbin, Maria Andréia-
dc.contributor.authorMoraes, Camila-
dc.contributor.authorCamargo, Enilton-
dc.contributor.authorMussi, Ricardo K.-
dc.contributor.authorAntunes, Edson-
dc.contributor.authorde Nucci, Gilberto-
dc.contributor.authorZanesco, Angelina-
dc.date.accessioned2014-05-27T11:22:30Z-
dc.date.accessioned2016-10-25T18:24:00Z-
dc.date.available2014-05-27T11:22:30Z-
dc.date.available2016-10-25T18:24:00Z-
dc.date.issued2007-07-01-
dc.identifierhttp://dx.doi.org/10.1016/j.cbpa.2006.08.037-
dc.identifier.citationComparative Biochemistry and Physiology - A Molecular and Integrative Physiology, v. 147, n. 3, p. 793-798, 2007.-
dc.identifier.issn1095-6433-
dc.identifier.issn1531-4332-
dc.identifier.urihttp://hdl.handle.net/11449/69732-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/69732-
dc.description.abstractThe aim of this work was to evaluate the effect of physical preconditioning in the responsiveness of rat pulmonary rings submitted to lung ischemia/reperfusion (IR). Wistar rats were divided into three groups: Sedentary sham-operated (SD/SHAM); sedentary submitted to ischemia/reperfusion (SD/IR) and trained submitted to ischemia/reperfusion (TR/IR) animals. Exercise training consisted in sessions of 60 min/day running sessions, 5 days/week for 8 weeks. Left pulmonary IR was performed by occluding for 90 min and reperfusing for 120 min. After that, pulmonary arteries were isolated and concentration-response curves to acetylcholine (ACh), histamine (HIST), sodium nitroprusside (SNP), phenylephrine and U46619 were obtained. Neither potency (- log EC50) nor maximal responses (Emax) were modified for ACh and HIST in all groups. On the other hand, the potency for SNP was significantly increased in TR/IR group (8.23 ± 0.06) compared to SD/IR group (7.85 ± 0.04). Contractile responses mediated by a-adrenergic receptor were markedly decreased in IR groups (SD/IR: 6.75 ± 0.06 and TR/IR: 6.62 ± 0.04) compared to SD/SHAM (7.33 ± 0.05). No changes were seen for the U46619 in all groups. In conclusion, the present study shows that exercise training has no protective actions in the local blood vessel where the IR process takes place. © 2006 Elsevier Inc. All rights reserved.en
dc.format.extent793-798-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectContractile responses-
dc.subjectExercise training-
dc.subjectPulmonary artery ring-
dc.subjectPulmonary ischemia/reperfusion-
dc.subjectRelaxation response-
dc.subject15 hydroxy 11alpha,9alpha epoxymethanoprosta 5,13 dienoic acid-
dc.subjectacetylcholine-
dc.subjectalpha adrenergic receptor-
dc.subjecthistamine-
dc.subjectnitroprusside sodium-
dc.subjectphenylephrine-
dc.subjectanimal experiment-
dc.subjectanimal model-
dc.subjectanimal tissue-
dc.subjectblood vessel-
dc.subjectconcentration response-
dc.subjectcontrolled study-
dc.subjectdrug mechanism-
dc.subjectexercise-
dc.subjectischemia-
dc.subjectmale-
dc.subjectnonhuman-
dc.subjectprotection-
dc.subjectpulmonary artery-
dc.subjectrat-
dc.subjectreperfusion-
dc.subjectrespiratory system-
dc.subjectrunning-
dc.subjectsitting-
dc.subjecttherapy effect-
dc.subjectAnimals-
dc.subjectBlood Pressure-
dc.subjectBody Weight-
dc.subjectDose-Response Relationship, Drug-
dc.subjectLung-
dc.subjectNitrates-
dc.subjectNitrites-
dc.subjectPhysical Conditioning, Animal-
dc.subjectPulmonary Artery-
dc.subjectRats-
dc.subjectRats, Wistar-
dc.subjectReperfusion Injury-
dc.subjectVasoconstrictor Agents-
dc.subjectVasodilator Agents-
dc.subjectAnimalia-
dc.subjectRattus-
dc.subjectRattus norvegicus-
dc.titleInfluence of physical preconditioning on the responsiveness of rat pulmonary artery after pulmonary ischemia/reperfusionen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)-
dc.description.affiliationDepartment of Physical Education Institute of Biosciences University of São Paulo State (UNESP), Rio Claro, SP-
dc.description.affiliationDepartment of Pharmacology Faculty of Medical Sciences State University of Campinas (UNICAMP), P.O. Box 6111, 13084-971 Campinas, SP-
dc.description.affiliationDepartments of Thoracic Surgery Faculty of Medical Sciences State University of Campinas (UNICAMP), 13084-971 Campinas, SP-
dc.description.affiliationUnespDepartment of Physical Education Institute of Biosciences University of São Paulo State (UNESP), Rio Claro, SP-
dc.identifier.doi10.1016/j.cbpa.2006.08.037-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofComparative Biochemistry and Physiology - A Molecular and Integrative Physiology-
dc.identifier.scopus2-s2.0-34248569667-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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