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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/69733
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dc.contributor.authorRibeiro, Daniel A.-
dc.contributor.authorCalvi, Sueli Aparecida-
dc.contributor.authorPicka, Mariele M.-
dc.contributor.authorPersi, Eliana-
dc.contributor.authorde Carvalho, Thaís B.-
dc.contributor.authorCaetano, Priscila K.-
dc.contributor.authorNagoshi, Lidiana R.-
dc.contributor.authorLima, Carlos R.G.-
dc.contributor.authorMachado, Jussara M.-
dc.contributor.authorSalvadori, Daisy Maria Favero-
dc.date.accessioned2014-05-27T11:22:30Z-
dc.date.accessioned2016-10-25T18:24:00Z-
dc.date.available2014-05-27T11:22:30Z-
dc.date.available2016-10-25T18:24:00Z-
dc.date.issued2007-07-01-
dc.identifierhttp://dx.doi.org/10.1016/j.exppara.2006.12.007-
dc.identifier.citationExperimental Parasitology, v. 116, n. 3, p. 296-301, 2007.-
dc.identifier.issn0014-4894-
dc.identifier.issn1090-2449-
dc.identifier.urihttp://hdl.handle.net/11449/69733-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/69733-
dc.description.abstractThis study aimed to evaluate whether experimental Chagas disease in acute phase under benznidazole therapy can cause DNA damage in peripheral blood, liver, heart, and spleen cells or induce nitric oxide synthesis in spleen cells. Twenty Balb/c mice were distributed into four groups: control (non-infected animals); Trypanosoma cruzi infected; T. cruzi infected and submitted to benznidazole therapy; and only treated with benznidazole. The results obtained with the single cell gel (comet) assay showed that T. cruzi was able induce DNA damage in heart cells of both benznidazole treated or untreated infected mice. Similarly, T. cruzi infected animals showed an increase of DNA lesions in spleen cells. Regarding nitric oxide synthesis, statistically significant differences (p < 0.05) were observed in all experimental groups compared to negative control, the strongest effect observed in the T. cruzi infected group. Taken together, these results indicate that T. cruzi may increase the level of DNA damage in mice heart and spleen cells. Probably, nitric oxide plays an important role in DNA damaging whereas benznidazole was able to minimize induced T. cruzi genotoxic effects in spleen cells. © 2006 Elsevier Inc. All rights reserved.en
dc.format.extent296-301-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectChagas disease-
dc.subjectNitric oxide-
dc.subjectSingle cell gel (comet) assay-
dc.subjectTrypanosoma cruzi-
dc.subjectbenznidazole-
dc.subjectnitric oxide-
dc.subjectacute phase response-
dc.subjectanimal cell-
dc.subjectanimal experiment-
dc.subjectcomet assay-
dc.subjectcontrolled study-
dc.subjectDNA damage-
dc.subjectDNA strand breakage-
dc.subjectexperimental infection-
dc.subjectgenotoxicity-
dc.subjectheart injury-
dc.subjectmale-
dc.subjectmouse-
dc.subjectnonhuman-
dc.subjectpriority journal-
dc.subjectspleen injury-
dc.subjectstatistical significance-
dc.subjecttherapy effect-
dc.subjecttreatment outcome-
dc.subjectAnimals-
dc.subjectBlood Cells-
dc.subjectChagas Disease-
dc.subjectDNA Damage-
dc.subjectLiver-
dc.subjectMale-
dc.subjectMice-
dc.subjectMice, Inbred BALB C-
dc.subjectMyocardium-
dc.subjectNeoplasms-
dc.subjectNitric Oxide-
dc.subjectNitroimidazoles-
dc.subjectRandom Allocation-
dc.subjectSpleen-
dc.subjectTrypanocidal Agents-
dc.subjectAnimalia-
dc.subjectMus-
dc.titleDNA damage and nitric oxide synthesis in experimentally infected Balb/c mice with Trypanosoma cruzien
dc.typeoutro-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationDepartment Health Sciences Federal University of Sao Paulo UNIFESP, SP-
dc.description.affiliationDepartment of Pathology Botucatu Medical School Sao Paulo State University, SP-
dc.description.affiliationDepartment of Tropical Diseases and Image Diagnosis Botucatu Medical School Sao Paulo State University, SP-
dc.description.affiliationUnespDepartment of Pathology Botucatu Medical School Sao Paulo State University, SP-
dc.description.affiliationUnespDepartment of Tropical Diseases and Image Diagnosis Botucatu Medical School Sao Paulo State University, SP-
dc.identifier.doi10.1016/j.exppara.2006.12.007-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofExperimental Parasitology-
dc.identifier.scopus2-s2.0-34248211136-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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