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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/69763
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dc.contributor.authorViegas-Junior, Cláudio-
dc.contributor.authorDanuello, Amanda-
dc.contributor.authorBolzani, Vanderlan da Silva-
dc.contributor.authorBarreiro, Eliezer J.-
dc.contributor.authorFraga, Carlos Alberto M.-
dc.date.accessioned2014-05-27T11:22:31Z-
dc.date.accessioned2016-10-25T18:24:03Z-
dc.date.available2014-05-27T11:22:31Z-
dc.date.available2016-10-25T18:24:03Z-
dc.date.issued2007-07-01-
dc.identifierhttp://dx.doi.org/10.2174/092986707781058805-
dc.identifierhttp://www.ingentaconnect.com/content/ben/cmc/2007/00000014/00000017/art00003-
dc.identifier.citationCurrent Medicinal Chemistry, v. 14, n. 17, p. 1829-1852, 2007.-
dc.identifier.issn0929-8673-
dc.identifier.urihttp://hdl.handle.net/11449/69763-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/69763-
dc.description.abstractMolecular hybridization is a new concept in drug design and development based on the combination of pharmacophoric moieties of different bioactive substances to produce a new hyrid compound with improved affinity and efficacy, when compared to the parent drugs. Additionally, this strategy can results in compounds presenting modified selectivity profile, different and/or dual modes of action and reduced undesired side effects. So, in this described several example of different strategies for drug design, discovery and pharmacomodulation focused on new innovative hybrid compounds presenting analgesic, anti-inflammatory, platelet anti-aggregating, anti-infections, anticancer, cardio- and neuroactive properties.en
dc.format.extent1829-1852-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectDrug design-
dc.subjectHybrid compounds-
dc.subjectMolecular hybridization-
dc.subjectPharmacophoric group combination-
dc.subject1,2,3,11a tetrahydro 8 hydroxy 7 methoxy 5h pyrrolo[2,1 c][1,4]benzodiazepin 5 one-
dc.subject1h 1,2,4 oxadiazolo[4,3 a]quinoxalin 1 one-
dc.subjectacetylsalicylic acid-
dc.subjectagmatine-
dc.subjectalpha tocopherol-
dc.subjectanalgesic agent-
dc.subjectanthramycin-
dc.subjectantiinfective agent-
dc.subjectantiinflammatory agent-
dc.subjectantineoplastic agent-
dc.subjectantithrombocytic agent-
dc.subjectbenzocaine-
dc.subjectciprofloxacin-
dc.subjectdipyrone-
dc.subjectdistamycin A-
dc.subjectdolastatin-
dc.subjectgeldanamycin-
dc.subjectlidocaine-
dc.subjectlosartan-
dc.subjectmetoclopramide-
dc.subjectmitiglinide-
dc.subjectnateglinide-
dc.subjectnorfloxacin-
dc.subjectprocainamide-
dc.subjectpropranolol-
dc.subjectsparfloxacin-
dc.subjecttaltobulin-
dc.subjectunindexed drug-
dc.subjecturamustine-
dc.subjectzatebradine-
dc.subjectanalgesia-
dc.subjectantiarrhythmic activity-
dc.subjectantiinflammatory activity-
dc.subjectantimicrobial activity-
dc.subjectantineoplastic activity-
dc.subjectantioxidant activity-
dc.subjectbinding affinity-
dc.subjectblood pressure regulation-
dc.subjectdrug design-
dc.subjectdrug efficacy-
dc.subjectdrug mechanism-
dc.subjectdrug research-
dc.subjectdrug selectivity-
dc.subjectdrug structure-
dc.subjecthuman-
dc.subjectmolecular hybridization-
dc.subjectnonhuman-
dc.subjectpharmacophore-
dc.subjectreview-
dc.subjectsmooth muscle relaxation-
dc.subjectstructure activity relation-
dc.subjectthrombocyte aggregation inhibition-
dc.subjectvasodilatation-
dc.subjectAnalgesics-
dc.subjectAnimals-
dc.subjectAnti-Infective Agents-
dc.subjectAnti-Inflammatory Agents, Non-Steroidal-
dc.subjectAntineoplastic Agents-
dc.subjectCardiovascular Agents-
dc.subjectDrug Design-
dc.subjectFibrinolytic Agents-
dc.subjectHumans-
dc.subjectHypoglycemic Agents-
dc.subjectLigands-
dc.titleMolecular hybridization: A useful tool in the design of new drug prototypesen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)-
dc.description.affiliationInstituto de Química Universidade Estadual Paulista Júlio de Mesquita Filho, P.O. Box 355, 14801-970 Araraquara, SP-
dc.description.affiliationLaboratorio de Avaliacao e Sintese de Substancias Bioativas (LASSBio) Faculdade de Farmácia Universidade Federal do Rio de Janeiro, P.O. Box 68023, 21944-971 Rio de Janeiro, RJ-
dc.description.affiliationUnespInstituto de Química Universidade Estadual Paulista Júlio de Mesquita Filho, P.O. Box 355, 14801-970 Araraquara, SP-
dc.identifier.doi10.2174/092986707781058805-
dc.identifier.wosWOS:000247774200003-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofCurrent Medicinal Chemistry-
dc.identifier.scopus2-s2.0-34547484265-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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