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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/70008
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dc.contributor.authorBarbastefano, Victor-
dc.contributor.authorCola, Maira-
dc.contributor.authorLuiz-Ferreira, Anderson-
dc.contributor.authorFarias-Silva, Elisângela-
dc.contributor.authorHiruma-Lima, Clélia A.-
dc.contributor.authorRinaldo, Daniel-
dc.contributor.authorVilegas, Wagner-
dc.contributor.authorSouza-Brito, Alba R.M.-
dc.date.accessioned2014-05-27T11:22:39Z-
dc.date.accessioned2016-10-25T18:24:36Z-
dc.date.available2014-05-27T11:22:39Z-
dc.date.available2016-10-25T18:24:36Z-
dc.date.issued2007-12-01-
dc.identifierhttp://dx.doi.org/10.1016/j.fitote.2007.07.003-
dc.identifier.citationFitoterapia, v. 78, n. 7-8, p. 545-551, 2007.-
dc.identifier.issn0367-326X-
dc.identifier.urihttp://hdl.handle.net/11449/70008-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/70008-
dc.description.abstractMethanolic (VPME) and chloroformic (VPCL) extracts, obtained from the aerial parts of Vernonia polyanthes, were investigated for its antiulcerogenic properties. Administration of VPME (250 mg/kg) and VPCL (50 mg/kg) significantly inhibited the gastric mucosa damage (64% and 90%, respectively) caused by absolute ethanol (p.o.). Otherwise, in NSAID-induced gastric damage, their gastroprotective effects have decreased. Since the VPCL extract resulted to be more effective than the VPME we focused our efforts over VPCL action mechanism of action. © 2007 Elsevier B.V. All rights reserved.en
dc.format.extent545-551-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectAction mechanisms-
dc.subjectAntiulcerogenic activity-
dc.subjectVernonia polyanthes-
dc.subjectalcohol-
dc.subjectantiulcer agent-
dc.subjectcarbenoxolone-
dc.subjectcimetidine-
dc.subjectlansoprazole-
dc.subjectn ethylmaleimide-
dc.subjectn(g) nitroarginine methyl ester-
dc.subjectnonsteroid antiinflammatory agent-
dc.subjectpiroxicam-
dc.subjectplant extract-
dc.subjectunclassified drug-
dc.subjectvernonia polyanthes chloroformic extract-
dc.subjectVernonia polyanthes extract-
dc.subjectvernonia polyanthes methanolic extract-
dc.subjectanimal experiment-
dc.subjectanimal model-
dc.subjectdrug inhibition-
dc.subjectdrug mechanism-
dc.subjectmale-
dc.subjectmedicinal plant-
dc.subjectmouse-
dc.subjectnonhuman-
dc.subjectpriority journal-
dc.subjectrat-
dc.subjectstomach mucosa lesion-
dc.subjectvernonia polyanthes-
dc.subjectAnimals-
dc.subjectAnti-Inflammatory Agents, Non-Steroidal-
dc.subjectAnti-Ulcer Agents-
dc.subjectDose-Response Relationship, Drug-
dc.subjectEthanol-
dc.subjectMale-
dc.subjectPhytotherapy-
dc.subjectPlant Components, Aerial-
dc.subjectPlant Extracts-
dc.subjectRats-
dc.subjectRats, Wistar-
dc.subjectStomach Ulcer-
dc.subjectVernonia-
dc.titleVernonia polyanthes as a new source of antiulcer drugsen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationDepartamento de Fisiologia e Biofísica Instituto de Biologia Universidade Estadual de Campinas (UNICAMP), Cidade Universitaria Zeferino Vaz, s/n, CP 6109, CEP13083-970 Campinas, SP-
dc.description.affiliationDepartamento de Fisiologia Instituto de Biociências Universidade Estadual Paulista (UNESP), Botucatu, SP-
dc.description.affiliationDepartamento de Química Orgânica Instituto de Química Universidade Estadual Paulista (UNESP), Araraquara, SP-
dc.description.affiliationUnespDepartamento de Fisiologia Instituto de Biociências Universidade Estadual Paulista (UNESP), Botucatu, SP-
dc.description.affiliationUnespDepartamento de Química Orgânica Instituto de Química Universidade Estadual Paulista (UNESP), Araraquara, SP-
dc.identifier.doi10.1016/j.fitote.2007.07.003-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofFitoterapia-
dc.identifier.scopus2-s2.0-35448985425-
dc.identifier.orcid0000-0002-8645-3777pt
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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