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dc.contributor.authorArruda-Neto, J. D T-
dc.contributor.authorBittencourt-Oliveira, M. C.-
dc.contributor.authorSchenberg, A. C G-
dc.contributor.authorSilva, E. C.-
dc.contributor.authorMesa, J.-
dc.contributor.authorRodrigues, T. E.-
dc.contributor.authorGarcia, F.-
dc.contributor.authorLouvison, M.-
dc.contributor.authorPaula, C. R.-
dc.identifier.citation8th International Topical Meeting on Nuclear Applications and Utilization of Accelerators, ACCAPP'07, p. 398-404.-
dc.description.abstractA major challenge in cancer radiotherapy is to deliver a lethal dose of radiation to the target volume while minimizing damage to the surrounding normal tissue. We have proposed a model on how treatment efficacy might be improved by interfering with biological responses to DNA damage using exogenous electric fields as a strategy to drastically reduce radiation doses in cancer therapy. This approach is demonstrated at this Laboratory through case studies with prokaryotes (bacteria) and eukaryotes (yeast) cells, in which cellkilling rates induced by both gamma radiation and exogenous electric fields were measured. It was found that when cells exposed to gamma radiation are immediately submitted to a weak electric field, cell death increases more than an order of magnitude compared to the effect of radiation alone. This finding suggests, although does not prove, that DNA damage sites are reached and recognized by means of long-range electric DNA-protein interaction, and that exogenous electric fields could destructively interfere with this process. As a consequence, DNA repair is avoided leading to massive cell death. Here we are proposing the use this new technique for the design and construction of novel radiotherapy facilities associated with linac generated gamma beams under controlled conditions of dose and beam intensity.en
dc.subjectCell death-
dc.subjectElectric field effects-
dc.subjectElectric field measurement-
dc.subjectElectric fields-
dc.subjectGamma rays-
dc.subjectLinear accelerators-
dc.subjectNucleic acids-
dc.subjectOrganic acids-
dc.subjectQuantum optics-
dc.subjectTheorem proving-
dc.subjectBeam intensities-
dc.subjectBiological responses-
dc.subjectCancer therapies-
dc.subjectCase studies-
dc.subjectControlled conditions-
dc.subjectDesign and constructions-
dc.subjectDna damages-
dc.subjectDna repairs-
dc.subjectGamma radiation sources-
dc.subjectGamma radiations-
dc.subjectLethal doses-
dc.subjectNew techniques-
dc.subjectNormal tissues-
dc.subjectProtein interactions-
dc.subjectRadiation doses-
dc.subjectTarget volumes-
dc.titleDeveloping new radiotherapy techniques using linac based gamma radiation sourcesen
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversity of Santo Amaro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionSanta Cruz State University-
dc.description.affiliationPhysics Institute University of São Paulo, São Paulo, SP-
dc.description.affiliationUNISA University of Santo Amaro, São Paulo, SP-
dc.description.affiliationESALQ University of São Paulo, Piracicaba, SP-
dc.description.affiliationInstitute for Biomedical Sciences University of São Paulo, São Paulo, SP-
dc.description.affiliationSão Paulo State University UNESP, Botucatu, SP-
dc.description.affiliationMedical Physics Group Santa Cruz State University, Ilhéus, BA-
dc.description.affiliationUnespSão Paulo State University UNESP, Botucatu, SP-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartof8th International Topical Meeting on Nuclear Applications and Utilization of Accelerators, ACCAPP'07-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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