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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/70223
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dc.contributor.authorNassar, Carlos Augusto-
dc.contributor.authorNassar, Patricia Oehlmeyer-
dc.contributor.authorAndia, Denise Carleto-
dc.contributor.authorGuimarães, Morgana Rodrigues-
dc.contributor.authorPepato, Maria Teresa-
dc.contributor.authorSpolidorio, Luis Carlos-
dc.date.accessioned2014-05-27T11:22:45Z-
dc.date.accessioned2016-10-25T18:25:04Z-
dc.date.available2014-05-27T11:22:45Z-
dc.date.available2016-10-25T18:25:04Z-
dc.date.issued2007-12-31-
dc.identifierhttp://dx.doi.org/10.1590/S1806-83242007000400002-
dc.identifier.citationBrazilian Oral Research, v. 21, n. 4, p. 293-297, 2007.-
dc.identifier.issn1806-8324-
dc.identifier.issn1807-3107-
dc.identifier.urihttp://hdl.handle.net/11449/70223-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/70223-
dc.description.abstractOne of the more serious complications following transplantation is the development of post-transplantation diabetes mellitus (PTDM), which has a major impact on the quality of life, with effects ranging from the control of glycemia times to increased susceptibility to infections and cardiovascular complications. It has been suggested that immunosuppressive therapy, mainly tacrolimus therapy, may be an important factor in the development of PTDM. There is a lack of studies that explore the effects of long-term tacrolimus on PTDM in animal protocols. The objective of this study was therefore to evaluate the effects of long-term therapy with tacrolimus in rats. One group was treated with tacrolimus, injected subcutaneously, in a daily dose of 1 mg/kg of body weight. The chosen dose was sufficient to achieve therapeutic tacrolimus serum levels. The experimental periods were 60, 120, 180 and 240 days. One group was used as control and received daily subcutaneous injections of saline solution during all periods. A tendency towards increased glycemia levels during the initial periods (60 and 120 days) was observed. However, at 180 and 240 days, the glycemia levels were not statistically different from that of the control group of the same period. It may thus be concluded that the deleterious effects of tacrolimus therapy on glycemia may be a time-related side effect.en
dc.format.extent293-297-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectDiabetes mellitus-
dc.subjectGlycemic index-
dc.subjectRats-
dc.subjectTacrolimus/adverse effects-
dc.subjectimmunosuppressive agent-
dc.subjecttacrolimus-
dc.subjectanimal-
dc.subjectbody weight-
dc.subjectcomparative study-
dc.subjectdisease model-
dc.subjectexperimental diabetes mellitus-
dc.subjectglucose blood level-
dc.subjectglycemic index-
dc.subjectimmunology-
dc.subjectkidney transplantation-
dc.subjectmale-
dc.subjectmetabolism-
dc.subjectrandomization-
dc.subjectrat-
dc.subjectSprague Dawley rat-
dc.subjecttime-
dc.subjectAnimals-
dc.subjectBlood Glucose-
dc.subjectBody Weight-
dc.subjectDiabetes Mellitus, Experimental-
dc.subjectDisease Models, Animal-
dc.subjectGlycemic Index-
dc.subjectImmunosuppressive Agents-
dc.subjectKidney Transplantation-
dc.subjectMale-
dc.subjectRandom Allocation-
dc.subjectRats, Sprague-Dawley-
dc.subjectTacrolimus-
dc.subjectTime Factors-
dc.titleBiochemical evaluation of glycemic levels of long-term tacrolimus therapy in ratsen
dc.typeoutro-
dc.contributor.institutionState University of the West of Parana-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationDepartment of Periodontology School of Dentistry of Cascavel State University of the West of Parana, Parana-
dc.description.affiliationDepartment of Periodontology School of Dentistry of Araraquara São Paulo State University, São Paulo-
dc.description.affiliationDepartment of Biochemistry School of Pharmaceutical Sciences of Araraquara São Paulo State University, São Paulo-
dc.description.affiliationDepartment of Oral Pathology School of Dentistry of Araraquara São Paulo State University, São Paulo-
dc.description.affiliation, Rua Recife 741, Cascavel, PR 85810-030-
dc.description.affiliationUnespDepartment of Periodontology School of Dentistry of Araraquara São Paulo State University, São Paulo-
dc.description.affiliationUnespDepartment of Biochemistry School of Pharmaceutical Sciences of Araraquara São Paulo State University, São Paulo-
dc.description.affiliationUnespDepartment of Oral Pathology School of Dentistry of Araraquara São Paulo State University, São Paulo-
dc.identifier.doi10.1590/S1806-83242007000400002-
dc.identifier.scieloS1806-83242007000400002-
dc.rights.accessRightsAcesso aberto-
dc.identifier.file2-s2.0-37349071053.pdf-
dc.relation.ispartofBrazilian Oral Research-
dc.identifier.scopus2-s2.0-37349071053-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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