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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/70410
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dc.contributor.authorFernandes, Daniara Cristina-
dc.contributor.authorRegasini, Luis Octávio-
dc.contributor.authorVellosa, José Carlos Rebuglio-
dc.contributor.authorPauletti, Patrícia Mendonça-
dc.contributor.authorCastro-Gamboa, Ian-
dc.contributor.authorBolzani, Vanderlan da Silva-
dc.contributor.authorOliveira, Olga Maria Mascarenhas-
dc.contributor.authorSilva, Dulce Helena Siqueira-
dc.date.accessioned2014-05-27T11:23:32Z-
dc.date.accessioned2016-10-25T18:25:29Z-
dc.date.available2014-05-27T11:23:32Z-
dc.date.available2016-10-25T18:25:29Z-
dc.date.issued2008-05-19-
dc.identifierhttp://dx.doi.org/10.1248/cpb.56.723-
dc.identifier.citationChemical and Pharmaceutical Bulletin, v. 56, n. 5, p. 723-726, 2008.-
dc.identifier.issn0009-2363-
dc.identifier.issn1347-5223-
dc.identifier.urihttp://hdl.handle.net/11449/70410-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/70410-
dc.description.abstractTwo new flavone glucosides, nitensosides A and B (1, 2), together with four known compounds, sorbifolin (3), sorbifolin 6-O-β-glucopyranoside (4), pedalitin (5), and pedalitin 6-O-β-glucopyranoside (6) were isolated from Pterogyne nitens. Their structures were elucidated from 1D and 2D NMR analysis, as well as by high resolution mass spectrometry. All the isolated flavones were evaluated for their myeloperoxidase (MPO) inhibitory activity. The most active compound, pedalitin, exhibited IC 50 value of 3.75 nM on MPO. Additionally, the radical-scavenging capacity of flavones 1-6 was evaluated towards ABTS and DPPH radicals and compared to standard compounds quercetin and Trolox®. © 2008 Pharmaceutical Society of Japan.en
dc.format.extent723-726-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectAntioxidant-
dc.subjectFlavone-
dc.subjectMyeloperoxidase-
dc.subjectPterogyne nitens-
dc.subjectRadical scavenging-
dc.subjectflavone derivative-
dc.subjectglucoside-
dc.subjectmyeloperoxidase-
dc.subjectnitensoside a-
dc.subjectnitensoside b-
dc.subjectpedalitin-
dc.subjectpedalitin 6 o beta glucopyranoside-
dc.subjectsorbifolin-
dc.subjectsorbifolin 6 o beta glucopyranoside-
dc.subjectcontrolled study-
dc.subjectdrug inhibition-
dc.subjectdrug structure-
dc.subjectIC 50-
dc.subjectlegume-
dc.subjectnonhuman-
dc.subjectnuclear magnetic resonance-
dc.subjectBenzothiazoles-
dc.subjectEnzyme Inhibitors-
dc.subjectFabaceae-
dc.subjectFlavones-
dc.subjectFree Radical Scavengers-
dc.subjectGlucosides-
dc.subjectMagnetic Resonance Spectroscopy-
dc.subjectPeroxidase-
dc.subjectPicrates-
dc.subjectPlant Leaves-
dc.subjectSulfonic Acids-
dc.titleMyeloperoxidase inhibitory and radical scavenging activities of flavones from Pterogyne nitensen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationDepartment of Organic Chemistry Institute of Chemistry UNESP-São Paulo State University, CP 355, Araraquara, SP, CEP 14801-970-
dc.description.affiliationDepartment of Biochemistry and Chemical Technology Institute of Chemistry UNESP-São Paulo State University, CP 355, Araraquara, SP, CEP 14801-970-
dc.description.affiliationUnespDepartment of Organic Chemistry Institute of Chemistry UNESP-São Paulo State University, CP 355, Araraquara, SP, CEP 14801-970-
dc.description.affiliationUnespDepartment of Biochemistry and Chemical Technology Institute of Chemistry UNESP-São Paulo State University, CP 355, Araraquara, SP, CEP 14801-970-
dc.identifier.doi10.1248/cpb.56.723-
dc.identifier.wosWOS:000256184200021-
dc.rights.accessRightsAcesso aberto-
dc.relation.ispartofChemical and Pharmaceutical Bulletin-
dc.identifier.scopus2-s2.0-43449110138-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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