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dc.contributor.authorLuchini, Ana Carolina-
dc.contributor.authorRodrigues-Orsi, Patrícia-
dc.contributor.authorCestari, Silvia Helena-
dc.contributor.authorSeito, Leonardo Noboru-
dc.contributor.authorWitaicenis, Aline-
dc.contributor.authorPellizzon, Claudia Helena-
dc.contributor.authorDi Stasi, Luiz Cláudio-
dc.date.accessioned2014-05-27T11:23:35Z-
dc.date.accessioned2016-10-25T18:25:40Z-
dc.date.available2014-05-27T11:23:35Z-
dc.date.available2016-10-25T18:25:40Z-
dc.date.issued2008-07-01-
dc.identifierhttp://dx.doi.org/10.1248/bpb.31.1343-
dc.identifier.citationBiological and Pharmaceutical Bulletin, v. 31, n. 7, p. 1343-1350, 2008.-
dc.identifier.issn0918-6158-
dc.identifier.issn1347-5215-
dc.identifier.urihttp://hdl.handle.net/11449/70455-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/70455-
dc.description.abstractCoumarins represent an important class of phenolic compounds with multiple biological activities, including inhibition of lipidic peroxidation and neutrophil-dependent anion superoxide generation, anti-inflammatory and immunosuppressor actions. All of these proprieties are essential for that a drug may be used in the treatment of inflammatory bowel disease. The present study examined intestinal anti-inflammatory activity of coumarin and its derivative, the 4-hydroxycoumarin on experimental ulcerative colitis in rats. This was performed in two different experimental settings, i.e. when the colonic mucosa is intact or when the mucosa is in process of recovery after an initial insult. The results obtained revealed that the coumarin and 4-hydroxycoumarin, at doses of 5 and 25 mg/kg, significantly attenuated the colonic damage induced by trinitrobenzenesulphonic acid (TNBS) in both situations, as evidenced macroscopically, microscopically and biochemically. This effect was related to an improvement in the colonic oxidative status, since coumarin and 4-hydroxycoumarin prevented the glutathione depletion that occurred as a consequence of the colonic inflammation. © 2008 Pharmaceutical Society of Japan.en
dc.format.extent1343-1350-
dc.language.isoeng-
dc.sourceScopus-
dc.subject4-hydroxycoumarin-
dc.subjectColitis relapse-
dc.subjectCoumarin-
dc.subjectRat colitis-
dc.subject4 hydroxycoumarin-
dc.subjectcoumarin-
dc.subjectglutathione-
dc.subjectphenol derivative-
dc.subjectsalazosulfapyridine-
dc.subjectsuperoxide-
dc.subjecttrinitrobenzenesulfonic acid-
dc.subjectanimal experiment-
dc.subjectanimal model-
dc.subjectanimal tissue-
dc.subjectantiinflammatory activity-
dc.subjectcolon injury-
dc.subjectcolon mucosa-
dc.subjectcontrolled study-
dc.subjectdrug dose comparison-
dc.subjectenteritis-
dc.subjectlipid peroxidation-
dc.subjectmale-
dc.subjectneutrophil-
dc.subjectnonhuman-
dc.subjectoxidative stress-
dc.subjectrat-
dc.subjecttreatment outcome-
dc.subjectulcerative colitis-
dc.subject4-Hydroxycoumarins-
dc.subjectAcute Disease-
dc.subjectAlkaline Phosphatase-
dc.subjectAnimals-
dc.subjectAnti-Inflammatory Agents-
dc.subjectChronic Disease-
dc.subjectColitis-
dc.subjectColon-
dc.subjectCoumarins-
dc.subjectDiarrhea-
dc.subjectGastrointestinal Agents-
dc.subjectGlutathione-
dc.subjectMale-
dc.subjectOrgan Size-
dc.subjectPeroxidase-
dc.subjectRats-
dc.subjectRats, Wistar-
dc.subjectRecurrence-
dc.subjectSulfasalazine-
dc.subjectTrinitrobenzenesulfonic Acid-
dc.titleIntestinal anti-inflammatory activity of coumarin and 4-hydroxycoumarin in the trinitrobenzenesulphonic acid model of rat colitisen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationLaboratory of Phytomedicines Department of Pharmacology São Paulo State University (UNESP), Botucatu, 18618-000, SP-
dc.description.affiliationDepartament of Morphology Instituto de Biociências São Paulo State University (UNESP), Botucatu, 18618-000, SP-
dc.description.affiliationUnespLaboratory of Phytomedicines Department of Pharmacology São Paulo State University (UNESP), Botucatu, 18618-000, SP-
dc.description.affiliationUnespDepartament of Morphology Instituto de Biociências São Paulo State University (UNESP), Botucatu, 18618-000, SP-
dc.identifier.doi10.1248/bpb.31.1343-
dc.identifier.wosWOS:000258169100009-
dc.rights.accessRightsAcesso aberto-
dc.relation.ispartofBiological and Pharmaceutical Bulletin-
dc.identifier.scopus2-s2.0-46449087882-
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