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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/70482
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dc.contributor.authorMoraes, Camila de-
dc.contributor.authorDavel, Ana Paula Couto-
dc.contributor.authorRossoni, Luciana Venturini-
dc.contributor.authorAntunes, Edson-
dc.contributor.authorZanesco, Angelina-
dc.date.accessioned2014-05-27T11:23:36Z-
dc.date.accessioned2016-10-25T18:25:44Z-
dc.date.available2014-05-27T11:23:36Z-
dc.date.available2016-10-25T18:25:44Z-
dc.date.issued2008-07-14-
dc.identifierhttp://dx.doi.org/10.1186/1472-6793-8-12-
dc.identifier.citationBMC Physiology, v. 8, n. 1, 2008.-
dc.identifier.issn1472-6793-
dc.identifier.urihttp://hdl.handle.net/11449/70482-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/70482-
dc.description.abstractBackground. Obesity has been associated with a variety of disease such as type II diabetes mellitus, arterial hypertension and atherosclerosis. Evidences have shown that exercise training promotes beneficial effects on these disorders, but the underlying mechanisms are not fully understood. The aim of this study was to investigate whether physical preconditioning prevents the deleterious effect of high caloric diet in vascular reactivity of rat aortic and mesenteric rings. Methods. Male Wistar rats were divided into sedentary (SD); trained (TR); sedentary diet (SDD) and trained diet (TRD) groups. Run training (RT) was performed in sessions of 60 min, 5 days/week for 12 weeks (70-80% VO2max). Triglycerides, glucose, insulin and nitrite/nitrate concentrations (NOx -) were measured. Concentration- response curves to acetylcholine (ACh) and sodium nitroprusside (SNP) were obtained. Expression of Cu/Zn superoxide dismutase (SOD-1) was assessed by Western blotting. Results. High caloric diet increased triglycerides concentration (SDD: 216 ± 25 mg/dl) and exercise training restored to the baseline value (TRD: 89 ± 9 mg/dl). Physical preconditioning significantly reduced insulin levels in both groups (TR: 0.54 ± 0.1 and TRD: 1.24 ± 0.3 ng/ml) as compared to sedentary animals (SD: 0.87 ± 0.1 and SDD: 2.57 ± 0.3 ng/ml). On the other hand, glucose concentration was slightly increased by high caloric diet, and RT did not modify this parameter (SD: 126 ± 6; TR: 140 ± 8; SDD: 156 ± 8 and TRD 153 ± 9 mg/dl). Neither high caloric diet nor RT modified NO x - levels (SD: 27 ± 4; TR: 28 ± 6; SDD: 27 ± 3 and TRD: 30 ± 2 μM). Functional assays showed that high caloric diet impaired the relaxing response to ACh in mesenteric (about 13%), but not in aortic rings. RT improved the relaxing responses to ACh either in aortic (28%, for TR and 16%, to TRD groups) or mesenteric rings (10%, for TR and 17%, to TRD groups) that was accompanied by up-regulation of SOD-1 expression and reduction in triglycerides levels. Conclusion. The improvement in endothelial function by physical preconditioning in mesenteric and aortic arteries from high caloric fed-rats was directly related to an increase in NO bioavailability to the smooth muscle mostly due to SOD-1 up regulation. © 2008 de Moraes et al; licensee BioMed Central Ltd.en
dc.language.isoeng-
dc.sourceScopus-
dc.subjectacetylcholine-
dc.subjectcopper zinc superoxide dismutase-
dc.subjectglucose-
dc.subjectinsulin-
dc.subjectnitrate-
dc.subjectnitrite-
dc.subjectnitroprusside sodium-
dc.subjecttriacylglycerol-
dc.subjectsuperoxide dismutase-
dc.subjectanimal experiment-
dc.subjectanimal food-
dc.subjectaorta-
dc.subjectcaloric intake-
dc.subjectcontrol group-
dc.subjectcontrolled study-
dc.subjectexercise-
dc.subjectfood intake-
dc.subjectmale-
dc.subjectmesentery-
dc.subjectnonhuman-
dc.subjectrat-
dc.subjectrelaxation training-
dc.subjectWestern blotting-
dc.subjectanimal-
dc.subjectfat intake-
dc.subjectmesenteric artery-
dc.subjectmetabolism-
dc.subjectmethodology-
dc.subjectphysiology-
dc.subjectvascular endothelium-
dc.subjectvasodilatation-
dc.subjectWistar rat-
dc.subjectAnimals-
dc.subjectAorta-
dc.subjectDietary Fats-
dc.subjectEndothelium, Vascular-
dc.subjectEnergy Intake-
dc.subjectMale-
dc.subjectMesenteric Arteries-
dc.subjectPhysical Conditioning, Animal-
dc.subjectRats-
dc.subjectRats, Wistar-
dc.subjectSuperoxide Dismutase-
dc.subjectVasodilation-
dc.titleExercise training improves relaxation response and SOD-1 expression in aortic and mesenteric rings from high caloric diet-fed ratsen
dc.typeoutro-
dc.contributor.institutionUniversidade Cruzeiro do Sul-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationBiological Science and Health Faculty of Physical Education Cruzeiro Do Sul University, São Paulo (SP)-
dc.description.affiliationDepartment of Physiology and Biophysics Institute of Biomedical Sciences (ICB-I) University of São Paulo, São Paulo (SP)-
dc.description.affiliationDepartment of Pharmacology Faculty of Medical Sciences University of Campinas, Campinas (SP)-
dc.description.affiliationDepartment of Physical Education Institute of Bioscience University of Sao Paulo State, Rio Claro (SP)-
dc.identifier.doi10.1186/1472-6793-8-12-
dc.rights.accessRightsAcesso aberto-
dc.identifier.file2-s2.0-46749100655.pdf-
dc.relation.ispartofBMC Physiology-
dc.identifier.scopus2-s2.0-46749100655-
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