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Localization of myosin-Va in subpopulations of cells in rat endocrine organs
  • Universidade Federal de Uberlândia (UFU)
  • Universidade de São Paulo (USP)
  • Universidade Estadual Paulista (UNESP)
Myosin-Va is a Ca 2+/calmodulin-regulated unconventional myosin involved in the transport of vesicles, membranous organelles, and macromolecular complexes composed of proteins and mRNA. The cellular localization of myosin-Va has been described in great detail in several vertebrate cell types, including neurons, melanocytes, lymphocytes, auditory tissues, and a number of cultured cells. Here, we provide an immunohistochemical view of the tissue distribution of myosin-Va in the major endocrine organs. Myosin-Va is highly expressed in the pineal and pituitary glands and in specific cell populations of other endocrine glands, especially the parafollicular cells of the thyroid, the principal cells of the parathyroid, the islets of Langerhans of the pancreas, the chromaffin cells of the adrenal medulla, and a subpopulation of interstitial testicular cells. Weak to moderate staining has been detected in steroidogenic cells of the adrenal cortex, ovary, and Leydig cells. Myosin-Va has also been localized to non-endocrine cells, such as the germ cells of the seminiferous epithelium and maturing oocytes and in the intercalated ducts of the exocrine pancreas. These data provide the first systematic description of myosin-Va localization in the major endocrine organs of rat. © 2008 Springer-Verlag.
Issue Date: 
Cell and Tissue Research, v. 333, n. 2, p. 263-279, 2008.
Time Duration: 
  • Endocrine glands
  • Germ cells
  • Immunohistochemistry
  • Myosin-Va
  • Neuroendocrine cells
  • Rat (Wistar)
  • messenger RNA
  • myosin Va
  • protein kinase (calcium,calmodulin)
  • adrenal cortex
  • animal cell
  • animal tissue
  • cell specificity
  • cell subpopulation
  • cell type
  • cellular distribution
  • chromaffin cell
  • controlled study
  • endocrine cell
  • hypophysis
  • immunohistochemistry
  • Leydig cell
  • lymphocyte
  • macromolecule
  • melanocyte
  • membrane vesicle
  • nerve cell
  • nonhuman
  • oocyte maturation
  • ovary cell
  • pancreas islet
  • parathyroid cell
  • pineal body
  • priority journal
  • protein expression
  • protein localization
  • rat
  • seminiferous tubule epithelium
  • steroidogenesis
  • testis cell
  • thyroid follicle cell
  • tissue distribution
  • Adrenal Glands
  • Animals
  • Endocrine Glands
  • Immunoblotting
  • Islets of Langerhans
  • Myosin Heavy Chains
  • Myosin Type V
  • Parathyroid Glands
  • Pineal Gland
  • Pituitary Gland
  • Rats
  • Thyroid Gland
  • Tissue Distribution
  • Rattus
  • Vertebrata
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Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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