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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/70603
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dc.contributor.authorAlmeida, Adelia Emilia de-
dc.contributor.authorDe Souza, Ana Luiza Ribeiro-
dc.contributor.authorAllegretti, Silmara Marques-
dc.contributor.authorFrezza, Tarsila Ferraz-
dc.contributor.authorPinto, Mara Cristina-
dc.contributor.authorFerreira, Antônio Gilberto-
dc.contributor.authorChin, Chung Man-
dc.date.accessioned2014-05-27T11:23:41Z-
dc.date.accessioned2016-10-25T18:26:03Z-
dc.date.available2014-05-27T11:23:41Z-
dc.date.available2016-10-25T18:26:03Z-
dc.date.issued2008-10-01-
dc.identifierhttp://dx.doi.org/10.1590/S1516-93322008000400022-
dc.identifier.citationRevista Brasileira de Ciencias Farmaceuticas/Brazilian Journal of Pharmaceutical Sciences, v. 44, n. 4, p. 749-754, 2008.-
dc.identifier.issn1516-9332-
dc.identifier.urihttp://hdl.handle.net/11449/70603-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/70603-
dc.description.abstractSchistosomiasis, an important disease in Brazil, is caused by a trematode of the genus Schistosoma, reaching millions of person in one of the most endemic region of this disease in the whole globe. The main goal of this work was to syntetize the 6-formyl- oxamniquine derivative and evaluate its biological activity. The 6-formyl-oxamniquine derivative was obtained by the oxidation of oxamniquine with MnO 2, applying CH 2Cl 2 as solvent at room temperature for 24 hours. The obtaintion of 6-formyl-oxamniquine derivative compound was confirmed by IR spectroscopy and 13C NMR and 1H NMR, presenting similar activity when compared to the commercial oxamniquine (Mansil®).en
dc.format.extent749-754-
dc.language.isopor-
dc.sourceScopus-
dc.subjectOoxamniquine-
dc.subjectSchistosoma mansoni-
dc.subjectSchistosomiasis-
dc.subject6 formyl oxamniquine derivative-
dc.subjectmanganese oxide-
dc.subjectoxamniquine-
dc.subjectunclassified drug-
dc.subjectBrazil-
dc.subjectcarbon nuclear magnetic resonance-
dc.subjectdrug activity-
dc.subjectdrug structure-
dc.subjectdrug synthesis-
dc.subjectinfrared spectroscopy-
dc.subjectproton nuclear magnetic resonance-
dc.subjectschistosomiasis-
dc.titleSíntese e atividade biológica do derivado 6-formil-oxamniquinapt
dc.title.alternativeSynthesis and biological activity of 6-formyl-oxamniquine derivativeen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)-
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)-
dc.description.affiliationLaboratório de Pesquisa e Desenvolvimento de Fármacos Departamento de Fármacos e Medicamentos Universidade Estadual Paulista Júlio de Mesquita Filho-
dc.description.affiliationDepartamento de Fármacos e Medicamentos Faculdade Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista Júlio de Mesquita Filho-
dc.description.affiliationLaboratório de Helmintologia Departamento de Parasitologia Universidade Estadual de Campinas-
dc.description.affiliationLaboratório de Parasitologia Departamento de Ciências Biológicas Universidade Estadual Paulista Júlio de Mesquita Filho-
dc.description.affiliationDepartamento de Química Orgânica Universidade Federal de São Carlos-
dc.description.affiliationFaculdade de Ciências Farmacêuticas UNESP, Rod. Araraquara-Jaú, km. 01, 14801-902 - Araraquara - SP-
dc.description.affiliationUnespLaboratório de Pesquisa e Desenvolvimento de Fármacos Departamento de Fármacos e Medicamentos Universidade Estadual Paulista Júlio de Mesquita Filho-
dc.description.affiliationUnespDepartamento de Fármacos e Medicamentos Faculdade Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista Júlio de Mesquita Filho-
dc.description.affiliationUnespLaboratório de Parasitologia Departamento de Ciências Biológicas Universidade Estadual Paulista Júlio de Mesquita Filho-
dc.description.affiliationUnespFaculdade de Ciências Farmacêuticas UNESP, Rod. Araraquara-Jaú, km. 01, 14801-902 - Araraquara - SP-
dc.identifier.doi10.1590/S1516-93322008000400022-
dc.identifier.scieloS1516-93322008000400022-
dc.identifier.wosWOS:000263804500022-
dc.rights.accessRightsAcesso aberto-
dc.identifier.file2-s2.0-59649108290.pdf-
dc.relation.ispartofRevista Brasileira de Ciencias Farmaceuticas/Brazilian Journal of Pharmaceutical Sciences-
dc.identifier.scopus2-s2.0-59649108290-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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