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dc.contributor.authorBotosso, Viviane F.-
dc.contributor.authorZanotto, Paolo M. de A.-
dc.contributor.authorUeda, Mirthes-
dc.contributor.authorArruda, Eurico-
dc.contributor.authorGilio, Alfredo E.-
dc.contributor.authorIeira, Sandra E.-
dc.contributor.authorStewien, Klaus E.-
dc.contributor.authorPeret, Teresa C. T.-
dc.contributor.authorJamal, Leda F.-
dc.contributor.authorPardini, Maria I. de M. C.-
dc.contributor.authorPinho, Joãr-
dc.contributor.authorMassad, Duardo-
dc.contributor.authorSant'Anna, Osvaldo A.-
dc.contributor.authorHolmes, Eddie C.-
dc.contributor.authorDurigon, Edison L.-
dc.contributor.authorComone, Priscila-
dc.contributor.authorDo Sacramento, Patrícia R.-
dc.contributor.authorDurigan, Mariana S.-
dc.contributor.authorOliveira, Danielle B. L.-
dc.contributor.authorMoraes, Claudia T. P.-
dc.contributor.authorCampo, Angélica C. A.-
dc.contributor.authorLeal, Andréia L.-
dc.contributor.authorSilva, Tereza S.-
dc.contributor.authorCarvalho, Ariane C. L.-
dc.contributor.authorTenório, Elisabeth C. N.-
dc.contributor.authorCintra, Otavio A. L.-
dc.contributor.authorAnsarah-Sobrinho, Camilo-
dc.contributor.authorProençna-Modena, José L.-
dc.contributor.authorIwamoto, Marisa A.-
dc.contributor.authorDe Paula, Flávia E.-
dc.contributor.authorSouza, Maria C. O.-
dc.contributor.authorVaz-de-Lima, Lourdes R. A.-
dc.contributor.authorMatsumoto, Tokiko K.-
dc.contributor.authorSato, Neuza N.-
dc.contributor.authorSalgado, Maristela M.-
dc.contributor.authorHong, Marisa A.-
dc.contributor.authorRequejo, Henry I.-
dc.contributor.authorBarbosa, Maria L.-
dc.contributor.authorOliveiveira, Carmem A. F.-
dc.contributor.authorPassos, Saulo D.-
dc.contributor.authorPecchini, Rogério-
dc.contributor.authorBerezin, Eitan-
dc.contributor.authorSchvartsman, Claudio-
dc.contributor.authorPannuti, Cláudio S.-
dc.contributor.authorCandeias, João M. G.-
dc.contributor.authorHan, Sang W.-
dc.contributor.authorGarcia, José F.-
dc.contributor.authorCarrilho, Flair J.-
dc.contributor.authorFigueiredo, Luíz T. M.-
dc.contributor.authorDuarte, Alberto J. Da S.-
dc.contributor.authorWolff, José L. C.-
dc.contributor.authorRahal, Paula-
dc.contributor.authorRichtzenhain, Leonardo J.-
dc.contributor.authorGonçales Jr., Fernando L.-
dc.contributor.authorDe Lima, Edimo G.-
dc.identifier.citationPLoS Pathogens, v. 5, n. 1, 2009.-
dc.description.abstractHuman respiratory syncytial virus (HRSV) is the major cause of lower respiratory tract infections in children under 5 years of age and the elderly, causing annual disease outbreaks during the fall and winter. Multiple lineages of the HRSVA and HRSVB serotypes co-circulate within a single outbreak and display a strongly temporal pattern of genetic variation, with a replacement of dominant genotypes occurring during consecutive years. In the present study we utilized phylogenetic methods to detect and map sites subject to adaptive evolution in the G protein of HRSVA and HRSVB. A total of 29 and 23 amino acid sites were found to be putatively positively selected in HRSVA and HRSVB, respectively. Several of these sites defined genotypes and lineages within genotypes in both groups, and correlated well with epitopes previously described in group A. Remarkably, 18 of these positively selected tended to revert in time to a previous codon state, producing a flipflop phylogenetic pattern. Such frequent evolutionary reversals in HRSV are indicative of a combination of frequent positive selection, reflecting the changing immune status of the human population, and a limited repertoire of functionally viable amino acids at specific amino acid sites.en
dc.subjectguanine nucleotide binding protein-
dc.subjectvirus protein-
dc.subjectamino acid substitution-
dc.subjectcontrolled study-
dc.subjectgene sequence-
dc.subjectmajor clinical study-
dc.subjectnucleotide sequence-
dc.subjectpreschool child-
dc.subjectRespiratory syncytial pneumovirus-
dc.subjectrespiratory syncytial pneumovirus a-
dc.subjectrespiratory syncytial pneumovirus b-
dc.subjectunindexed sequence-
dc.subjectvirus gene-
dc.subjectgenetic variability-
dc.subjectmolecular evolution-
dc.subjectrespiratory tract infection-
dc.subjectHuman respiratory syncytial virus-
dc.subjectHydrangea ringspot virus-
dc.subjectAmino Acid Substitution-
dc.subjectEvolution, Molecular-
dc.subjectGenetic Variation-
dc.subjectGTP-Binding Proteins-
dc.subjectRespiratory Syncytial Viruses-
dc.subjectRespiratory Tract Infections-
dc.subjectViral Proteins-
dc.titlePositive selection results in frequent reversible amino acid replacements in the G protein gene of human respiratory syncytial virusen
dc.contributor.institutionVirology Branch-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionInstituto Adolfo Lutz (IAL)-
dc.contributor.institutionCenters for Disease Control and Prevention-
dc.contributor.institutionSTD/AIDS Reference and Training Centre-
dc.contributor.institutionPennsylvania State University-
dc.contributor.institutionNational Institutes of Health-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationButantan Institute Virology Branch, Butantã, São Paulo-
dc.description.affiliationDepartment of Microbiology Institute of Biomedical Sciences University of São Paulo, São Paulo-
dc.description.affiliationDivision of Medical Biology Adolfo Lutz Institute, São Paulo-
dc.description.affiliationDepartment of Cell Biology School of Medicine of Ribeirão Preto University of São Paulo, Ribeirão Preto, São Paulo-
dc.description.affiliationPediatric Division University Hospital University of São Paulo, São Paulo-
dc.description.affiliationDivision of Viral Diseases National Center for Immunization and Respiratory Diseases Centers for Disease Control and Prevention, Atlanta, GA-
dc.description.affiliationSTD/AIDS Reference and Training Centre, São Paulo, São Paulo-
dc.description.affiliationState University of São Paulo, São Paulo-
dc.description.affiliationTropical Medicine Institute University of São Paulo, São Paulo-
dc.description.affiliationDepartment of Legal Medicine University of São Paulo Medical School, São Paulo-
dc.description.affiliationCenter for Infectious Disease Dynamics Department of Biology Pennsylvania State University, University Park, PA-
dc.description.affiliationFogarty International Center National Institutes of Health, Bethesda, MD-
dc.rights.accessRightsAcesso aberto-
dc.relation.ispartofPLoS Pathogens-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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