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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/71177
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dc.contributor.authorCarlos, Iracilda Z.-
dc.contributor.authorCarli, Camila B. A.-
dc.contributor.authorMaia, Danielle C. G.-
dc.contributor.authorBenzatti, Fernanda P.-
dc.contributor.authorLopes, Flavia C. M.-
dc.contributor.authorRoese, Fernanda M.-
dc.contributor.authorWatanabe, Márcio-
dc.contributor.authorMicheletti, Ana C.-
dc.contributor.authorSantos, Lourdes Campaner dos-
dc.contributor.authorVilegas, Wagner-
dc.contributor.authorHonda, Neli K.-
dc.date.accessioned2014-05-27T11:23:59Z-
dc.date.accessioned2016-10-25T18:27:27Z-
dc.date.available2014-05-27T11:23:59Z-
dc.date.available2016-10-25T18:27:27Z-
dc.date.issued2009-10-01-
dc.identifierhttp://dx.doi.org/10.1590/S0102-695X2009000600009-
dc.identifier.citationBrazilian Journal of Pharmacognosy, v. 19, n. 4, p. 847-852, 2009.-
dc.identifier.issn0102-695X-
dc.identifier.urihttp://hdl.handle.net/11449/71177-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/71177-
dc.description.abstractThe effects of isolated compounds from Brazilian lichens and their derivatives on H 2O 2 and NO production were studied using murine macrophages as a part of an attempt to understand their possible immunomodulatory properties. The compound cytotoxicity was studied using MTT assay. Macrophage stimulation was evaluated by the determination of NO (Griess assay) and H 2O 2 (horseradish peroxidase/phenol red) in supernatants of peritoneal macrophage cultures of Swiss mice. This research demonstrated stimulatory activities of some phenolic compounds isolated from lichens and their derivatives on H 2O 2 and NO production. Structure-activity relationships suggest several synthetic directions for further improvement of immunological activity.en
dc.format.extent847-852-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectHydrogen peroxide-
dc.subjectLichens-
dc.subjectMacrophages-
dc.subjectNitric oxide-
dc.subjectPhenolic compounds-
dc.subject8' o n propyl norstitic acid-
dc.subject9' o ethyl norstitic acid-
dc.subject9' o ethyl protocetraric acid-
dc.subject9' o iso propyl protocetraric acid-
dc.subject9' o methyl protocetraric acid-
dc.subject9' o n butyl protocetraric acid-
dc.subject9' o n hexyl protocetraric acid-
dc.subject9' o n pentyl protocetraric acid-
dc.subject9' o n propyl protocetraric acid-
dc.subject9' o sec butyl protocetraric acid-
dc.subject9' o terc butyl protocetraric acid-
dc.subjectcomprotocetraric acid-
dc.subjecthydrogen peroxide-
dc.subjectimmunostimulating agent-
dc.subjectlichexanthone-
dc.subjectmethyl protocetrate-
dc.subjectnitric oxide-
dc.subjectnitroblue tetrazolium-
dc.subjectnorstitic acid-
dc.subjectphenol derivative-
dc.subjectphysodic acid-
dc.subjectprotocetraric acid-
dc.subjectunclassified drug-
dc.subjectanimal cell-
dc.subjectcell stimulation-
dc.subjectcell viability-
dc.subjectcytotoxicity-
dc.subjectdrug determination-
dc.subjectdrug structure-
dc.subjectdrug synthesis-
dc.subjectimmune response-
dc.subjectimmunomodulation-
dc.subjectlichen-
dc.subjectmacrophage-
dc.subjectmouse-
dc.subjectnonhuman-
dc.subjectperitoneum-
dc.subjectstructure activity relation-
dc.subjectsupernatant-
dc.subjectSwiss Webster mouse-
dc.titleImmunostimulatory effects of the phenolic compounds from lichens on nitric oxide and hydrogen peroxide productionen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade Federal de Mato Grosso do Sul (UFMS)-
dc.description.affiliationDepartament of Clinical Analysis Faculdade de Ciências Farmacêuticas de Araraquara São Paulo State University, Post Office Box 502, Araraquara-SP 14801-902-
dc.description.affiliationDepartament of Chemistry Universidade Federal do Mato Grosso do Sul, Campo Grande-MS-
dc.description.affiliationDepartment of Organic Chemistry Instituto de Química de Araraquara São Paulo State University, Post Office Box 355, Araraquara-SP 14801-970-
dc.description.affiliationUnespDepartament of Clinical Analysis Faculdade de Ciências Farmacêuticas de Araraquara São Paulo State University, Post Office Box 502, Araraquara-SP 14801-902-
dc.description.affiliationUnespDepartment of Organic Chemistry Instituto de Química de Araraquara São Paulo State University, Post Office Box 355, Araraquara-SP 14801-970-
dc.identifier.doi10.1590/S0102-695X2009000600009-
dc.identifier.scieloS0102-695X2009000600009-
dc.identifier.wosWOS:000275593200009-
dc.rights.accessRightsAcesso aberto-
dc.identifier.file2-s2.0-77949514631.pdf-
dc.relation.ispartofBrazilian Journal of Pharmacognosy-
dc.identifier.scopus2-s2.0-77949514631-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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