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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/7170
Title: 
Coenzyme Q(10) and its effects in the treatment of neurodegenerative diseases
Author(s): 
Institution: 
  • Universidade de São Paulo (USP)
  • Universidade Estadual Paulista (UNESP)
ISSN: 
1984-8250
Abstract: 
According to clinical and pre-clinical studies, oxidative stress and its consequences may be the cause or, at least, a contributing factor, to a large number of neurodegenerative diseases. These diseases include common and debilitating disorders, characterized by progressive and irreversible loss of neurons in specific regions of the brain. The most common neurodegenerative diseases are Parkinson's disease, Huntington's disease, Alzheimer's disease and amyotrophic lateral sclerosis. Coenzyme Q(10) (CoQ(10)) has been extensively studied since its discovery in 1957. It is a component of the electron transportation chain and participates in aerobic cellular respiration, generating energy in the form of adenosine triphosphate (ATP). The property of CoQ(10) to act as an antioxidant or a pro-oxidant, suggests that it also plays an important role in the modulation of redox cellular status under physiological and pathological conditions, also performing a role in the ageing process. In several animal models of neurodegenerative diseases, CoQ(10) has shown beneficial effects in reducing disease progression. However, further studies are needed to assess the outcome and effectiveness of CoQ(10) before exposing patients to unnecessary health risks at significant costs.
Issue Date: 
1-Oct-2009
Citation: 
Brazilian Journal of Pharmaceutical Sciences. São Paulo: Univ São Paulo, Conjunto Quimicas, v. 45, n. 4, p. 607-618, 2009.
Time Duration: 
607-618
Publisher: 
Universidade de São Paulo (USP), Conjunto Quimicas
Keywords: 
  • Coenzyme Q(10)
  • Antioxidant
  • Oxidative stress
  • Neurodegenerative diseases
Source: 
http://dx.doi.org/10.1590/S1984-82502009000400002
URI: 
http://hdl.handle.net/11449/7170
Access Rights: 
Acesso aberto
Type: 
outro
Source:
http://repositorio.unesp.br/handle/11449/7170
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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