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dc.contributor.authordos Santos, Graciela Cristina-
dc.contributor.authorGreggi Antunes, Lusania Maria-
dc.contributor.authordos Santos, Antonio Cardozo-
dc.contributor.authorPires Bianchi, Maria de Lourdes-
dc.identifier.citationBrazilian Journal of Pharmaceutical Sciences. São Paulo: Univ São Paulo, Conjunto Quimicas, v. 45, n. 4, p. 607-618, 2009.-
dc.description.abstractAccording to clinical and pre-clinical studies, oxidative stress and its consequences may be the cause or, at least, a contributing factor, to a large number of neurodegenerative diseases. These diseases include common and debilitating disorders, characterized by progressive and irreversible loss of neurons in specific regions of the brain. The most common neurodegenerative diseases are Parkinson's disease, Huntington's disease, Alzheimer's disease and amyotrophic lateral sclerosis. Coenzyme Q(10) (CoQ(10)) has been extensively studied since its discovery in 1957. It is a component of the electron transportation chain and participates in aerobic cellular respiration, generating energy in the form of adenosine triphosphate (ATP). The property of CoQ(10) to act as an antioxidant or a pro-oxidant, suggests that it also plays an important role in the modulation of redox cellular status under physiological and pathological conditions, also performing a role in the ageing process. In several animal models of neurodegenerative diseases, CoQ(10) has shown beneficial effects in reducing disease progression. However, further studies are needed to assess the outcome and effectiveness of CoQ(10) before exposing patients to unnecessary health risks at significant costs.en
dc.publisherUniversidade de São Paulo (USP), Conjunto Quimicas-
dc.sourceWeb of Science-
dc.subjectCoenzyme Q(10)en
dc.subjectOxidative stressen
dc.subjectNeurodegenerative diseasesen
dc.titleCoenzyme Q(10) and its effects in the treatment of neurodegenerative diseasesen
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniv São Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Anal Clin Toxicol & Bromatol, BR-14040903 Ribeirao Preto, SP, Brazil-
dc.description.affiliationState Univ Julio de Mesquita Filho, Fac Pharmaceut Sci Araraquara, Dept Food & Nutr, Rio de Janeiro, Brazil-
dc.description.affiliationUnespState Univ Julio de Mesquita Filho, Fac Pharmaceut Sci Araraquara, Dept Food & Nutr, Rio de Janeiro, Brazil-
dc.rights.accessRightsAcesso aberto-
dc.relation.ispartofBrazilian Journal of Pharmaceutical Sciences-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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