You are in the accessibility menu

Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/71703
Full metadata record
DC FieldValueLanguage
dc.contributor.authordos Santos, Fabio V.-
dc.contributor.authorCalvo, Tamara R.-
dc.contributor.authorCólus, Ilce Mara S.-
dc.contributor.authorVilegas, Wagner-
dc.contributor.authorVaranda, Eliana Aparecida-
dc.date.accessioned2014-05-27T11:24:42Z-
dc.date.accessioned2016-10-25T18:28:41Z-
dc.date.available2014-05-27T11:24:42Z-
dc.date.available2016-10-25T18:28:41Z-
dc.date.issued2010-06-01-
dc.identifierhttp://dx.doi.org/10.1590/S0102-695X2010000300015-
dc.identifier.citationBrazilian Journal of Pharmacognosy, v. 20, n. 3, p. 382-389, 2010.-
dc.identifier.issn0102-695X-
dc.identifier.urihttp://hdl.handle.net/11449/71703-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/71703-
dc.description.abstractSome species of the plant genus Alchornea (family Euphorbiaceae) are widely used in popular medicine, mainly in South America and in Africa. Several kinds of biological activity have been seen in the species: antioxidant, antifungal, anti-inflammatory, antibacterial, cytotoxic against tumor cell lines and inhibitory to the replication of HIV-1 and HIV-2. In Brazil, the species Alchornea castaneaefolia Willd. A. Juss. and Alchornea glandulosa Poepp. & Endl. are used by the local population to treat rheumatism, arthritis and muscular pains. In view of the popular use of these plants as medicines and the potential risks from their consumption, we assessed the mutagenic potential of chloroform and methanol extracts of the leaves of these plant species, employing the in vivo micronucleus test and the Ames assay. The data obtained showed that the chloroform extracts were not mutagenic. The methanol extract of A. castaneaefolia was mutagenic to strain TA98 of Salmonella typhimurium and the methanol extract of A. glandulosa to strains TA98 and TA97a. The methanol extracts of both species of Alchornea were mutagenic in vivo at the largest dose employed. The probable mutagenic agents involved were the aglycone quercetin and amentoflavone, present in both species.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.format.extent382-389-
dc.language.isoeng-
dc.language.isopor-
dc.sourceScopus-
dc.subjectAlchornea-
dc.subjectAmes assay-
dc.subjectMedicinal plant-
dc.subjectMicronucleus-
dc.subjectMutagenicity-
dc.subjectchloroform extract-
dc.subjectcyclophosphamide-
dc.subjectmethanolic extract-
dc.subjectplant extract-
dc.subjectunclassified drug-
dc.subjectAlchornea castaneaefolia-
dc.subjectAlchornea glandulosa-
dc.subjectanimal experiment-
dc.subjectbacterial strain-
dc.subjectcontrolled study-
dc.subjectdrug cytotoxicity-
dc.subjectdrug isolation-
dc.subjectdrug screening-
dc.subjectEuphorbia-
dc.subjectfemale-
dc.subjectmale-
dc.subjectmicronucleus test-
dc.subjectmouse-
dc.subjectmutagen testing-
dc.subjectmutagenicity-
dc.subjectnonhuman-
dc.subjectplant leaf-
dc.subjectSalmonella microsome assay-
dc.subjectSalmonella typhimurium-
dc.titleMutagenicidade de duas espécies do gěnero Alchornea avaliadas através de ensaios com Salmonella microssomo e teste do micronúcleopt
dc.title.alternativeMutagenicity of two species of the genus Alchornea measured by Salmonella microsome assay and micronucleus testen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade Estadual de Londrina (UEL)-
dc.description.affiliationFaculty of Pharmaceutical Sciences Department of Biological Sciences São Paulo State University, Campus Araraquara, Rodovia Araraquara-Jaú km 1, 14801-902 Araraquara-SP-
dc.description.affiliationOrganic Chemistry Department Chemistry Institute São Paulo State University, PO Box 355, 14800-900 Araraquara-SP-
dc.description.affiliationDepartment of General Biology Biological Sciences Center Londrina State University, Londrina, PR-
dc.description.affiliationUnespFaculty of Pharmaceutical Sciences Department of Biological Sciences São Paulo State University, Campus Araraquara, Rodovia Araraquara-Jaú km 1, 14801-902 Araraquara-SP-
dc.description.affiliationUnespOrganic Chemistry Department Chemistry Institute São Paulo State University, PO Box 355, 14800-900 Araraquara-SP-
dc.identifier.doi10.1590/S0102-695X2010000300015-
dc.identifier.scieloS0102-695X2010000300015-
dc.identifier.wosWOS:000280833400014-
dc.rights.accessRightsAcesso aberto-
dc.identifier.file2-s2.0-77957604792.pdf-
dc.relation.ispartofBrazilian Journal of Pharmacognosy-
dc.identifier.scopus2-s2.0-77957604792-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

There are no files associated with this item.
 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.