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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/71798
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dc.contributor.authorSoares, Milena Botelho Pereira-
dc.contributor.authorLima, Ricardo Santana de-
dc.contributor.authorRocha, Leonardo Lima-
dc.contributor.authorVasconcelos, Juliana Fraga-
dc.contributor.authorRogatto, Silvia Regina-
dc.contributor.authorSantos, Ricardo Ribeiro dos-
dc.contributor.authorIacobas, Sanda-
dc.contributor.authorGoldenberg, Regina Coeli-
dc.contributor.authorIacobas, Dumitru Andrei-
dc.contributor.authorTanowitz, Herbert Bernard-
dc.contributor.authorCarvalho, Antonio Carlos Campos de-
dc.contributor.authorSpray, David Conover-
dc.date.accessioned2014-05-27T11:24:45Z-
dc.date.accessioned2016-10-25T18:28:55Z-
dc.date.available2014-05-27T11:24:45Z-
dc.date.available2016-10-25T18:28:55Z-
dc.date.issued2010-08-01-
dc.identifierhttp://dx.doi.org/10.1086/653481-
dc.identifier.citationJournal of Infectious Diseases, v. 202, n. 3, p. 416-426, 2010.-
dc.identifier.issn0022-1899-
dc.identifier.urihttp://hdl.handle.net/11449/71798-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/71798-
dc.description.abstractChronic chagasic cardiomyopathy is a leading cause of heart failure in Latin American countries. About 30% of Trypanosoma cruzi-infected individuals develop this severe symptomatic form of the disease, characterized by intense inflammatory response accompanied by fibrosis in the heart.We performed an extensive microarray analysis of hearts from a mouse model of this disease and identified significant alterations in expression of ~12% of the sampled genes. Extensive up-regulations were associated with immune-inflammatory responses (chemokines, adhesion molecules, cathepsins, and major histocompatibility complex molecules) and fibrosis (extracellular matrix components, lysyl oxidase, and tissue inhibitor of metalloproteinase 1). Our results indicate potentially relevant factors involved in the pathogenesis of the disease that may provide newtherapeutic targets in chronic Chagas disease. © 2010 by the Infectious Diseases Society of America.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)-
dc.format.extent416-426-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectactin binding protein-
dc.subjectbeta3 integrin-
dc.subjectcathepsin-
dc.subjectcathepsin H-
dc.subjectcathepsin S-
dc.subjectCD11b antigen-
dc.subjectCD38 antigen-
dc.subjectCD4 antigen-
dc.subjectCD52 antigen-
dc.subjectCD8 antigen-
dc.subjectcell adhesion molecule-
dc.subjectcell surface protein-
dc.subjectchemokine-
dc.subjectchemokine receptor-
dc.subjectchlordane-
dc.subjectcytokine receptor-
dc.subjectgalectin 3-
dc.subjectgamma interferon-
dc.subjectintercellular adhesion molecule 1-
dc.subjectinterleukin 10 receptor alpha-
dc.subjectmatrix metalloproteinase 14-
dc.subjectmetalloproteinase inhibitor-
dc.subjectPADGEM protein-
dc.subjectprotein lysine 6 oxidase-
dc.subjecttumor necrosis factor alpha-
dc.subjectanimal cell-
dc.subjectanimal experiment-
dc.subjectanimal model-
dc.subjectanimal tissue-
dc.subjectcell proliferation-
dc.subjectChagas disease-
dc.subjectchronic disease-
dc.subjectcontrolled study-
dc.subjectfemale-
dc.subjectgene expression-
dc.subjectheart failure-
dc.subjectheart muscle-
dc.subjectheart muscle fibrosis-
dc.subjecthistocompatibility complex-
dc.subjectimmune response-
dc.subjectimmune response gene-
dc.subjectimmunohistochemistry-
dc.subjectinflammation-
dc.subjectintracellular signaling-
dc.subjectmale-
dc.subjectmicroarray analysis-
dc.subjectmouse-
dc.subjectmyocarditis-
dc.subjectnonhuman-
dc.subjectnucleotide sequence-
dc.subjectpathogenesis-
dc.subjectphosphate transport-
dc.subjectpriority journal-
dc.subjectTrypanosoma cruzi-
dc.subjectupregulation-
dc.titleGene expression changes associated with myocarditis and fibrosis in hearts of mice with chronic chagasic cardiomyopathyen
dc.typeoutro-
dc.contributor.institutionFundação Oswaldo Cruz (FIOCRUZ)-
dc.contributor.institutionHospital São Rafael-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionHospital do Câncer A. C. Camargo-
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)-
dc.contributor.institutionInstituto Nacional de Cardiologia (INC)-
dc.contributor.institutionSociedade Beneficente Israelita Brasileira Albert Einstein (SBIBAE)-
dc.description.affiliationCentro de Pesquisas Gonçalo Moniz Fundação Oswaldo Cruz-
dc.description.affiliationHospital São Rafael, Salvador-
dc.description.affiliationDepartamento de Urologia Faculdade de Medicina Universidade do Estado de São Paulo, Botucatu-
dc.description.affiliationHospital do Câncer A. C. Camargo, São Paulo-
dc.description.affiliationInstituto de Biofísica Carlos Chagas Filho Universidade Federal do Rio de Janeiro-
dc.description.affiliationInstituto Nacional de Cardiologia, Rio de Janeiro-
dc.description.affiliationD. P. Purpura Department of Neuroscience Albert Einstein College of Medicine, Bronx, NY-
dc.description.affiliationDepartment of Medicine Albert Einstein College of Medicine, Bronx, NY-
dc.description.affiliationDepartment of Pathology Albert Einstein College of Medicine, Bronx, NY-
dc.identifier.doi10.1086/653481-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofJournal of Infectious Diseases-
dc.identifier.scopus2-s2.0-77954738641-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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