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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/71833
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dc.contributor.authorCamargo, João Lauro Viana de-
dc.date.accessioned2014-05-27T11:24:46Z-
dc.date.accessioned2016-10-25T18:29:00Z-
dc.date.available2014-05-27T11:24:46Z-
dc.date.available2016-10-25T18:29:00Z-
dc.date.issued2010-08-25-
dc.identifierhttp://www.apocpcontrol.org/page/apjcp_issues_view.php?sid=Entrez:PubMed&id=pmid:20593917&key=2010.11.1.7-
dc.identifier.citationAsian Pacific Journal of Cancer Prevention, v. 11, n. 1, p. 7-8, 2010.-
dc.identifier.issn1513-7368-
dc.identifier.urihttp://hdl.handle.net/11449/71833-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/71833-
dc.description.abstractIn 1996 the Brazilian Institute for the Environment (IBAMA) officially adopted a variation of the multiorgan initiation-promotion DMBDD bioassay as a valid source of evidence of the carcinogenic potential of pesticides. The protocol adopted by IBAMA was a modification of the one originally proposed by researchers led by Nobuyuki Ito, from the Nagoya City University Medical School. Among the modifications established in the Brazilian protocol were the use of both sexes of the outbreed Wistar strain of rats and two positive control test chemicals. The adoption of the modified DMBDD protocol was instrumental during the last decade for qualifying technical people and to spread knowledge on chemical carcinogenesis in Brazil.en
dc.format.extent7-8-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectCell proliferation-
dc.subjectEstrogen-
dc.subjectImmunosuppression-
dc.subjectMutagen/carcinogen screening-
dc.subjectTwo-year bioassay-
dc.subjectcarcinogen-
dc.subjectanimal-
dc.subjectantibody specificity-
dc.subjectbioassay-
dc.subjectBrazil-
dc.subjectcarcinogen testing-
dc.subjectchemically induced disorder-
dc.subjectconference paper-
dc.subjectdrug effect-
dc.subjectexperimental neoplasm-
dc.subjectfemale-
dc.subjectFischer 344 rat-
dc.subjectgovernment regulation-
dc.subjectmale-
dc.subjectpathology-
dc.subjectrat-
dc.subjectstandard-
dc.subjectAnimals-
dc.subjectBiological Assay-
dc.subjectCarcinogenicity Tests-
dc.subjectCarcinogens-
dc.subjectFemale-
dc.subjectGovernment Regulation-
dc.subjectMale-
dc.subjectNeoplasms, Experimental-
dc.subjectOrgan Specificity-
dc.subjectRats-
dc.subjectRats, Inbred F344-
dc.titleBrazilian experience with the medium-term multi-organ bioassay: Scientific and regulatory developmentsen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationDepartment of Pathology UNESP Medical School São Paulo State University, Botucatu-
dc.description.affiliationUnespDepartment of Pathology UNESP Medical School São Paulo State University, Botucatu-
dc.rights.accessRightsAcesso aberto-
dc.identifier.file2-s2.0-77955810808.pdf-
dc.relation.ispartofAsian Pacific Journal of Cancer Prevention-
dc.identifier.scopus2-s2.0-77955810808-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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