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dc.contributor.authorCavallini, Daniela Cardoso Umbelino-
dc.contributor.authorAbdalla, Dulcineia S. P.-
dc.contributor.authorPauly-Silveira, Nadiege D.-
dc.contributor.authorRossi, Elizeu Antonio-
dc.identifier.citationLatin American Journal of Pharmacy. La Plata: Colegio Farmaceuticos Provincia de Buenos Aires, v. 29, n. 8, p. 1419-1424, 2010.-
dc.description.abstractOxidized Low-Density Lipoproteins (oxLDL) and autoantibodies against oxLDL are important in the development of atherosclerotic lesions. Statins are efficacious in the control of dyslipidemia and prevention of atherosclerosis; however, many questions concerning the mechanism of action of such drugs remain unknown. This work investigated the effect of simvastatin on generation of autoantibodies against oxLDL and development of atherosclerosis in rabbits. The animals were divided into three groups: control, hypercholesterolemic, and hypercholesterolemic simvastatin (3.0 mg simvastatin/ kg body weight). Concentrations of autoantibodies against oxLDL were determined on days 0,30 and 60 of the experiment and the atherosclerotic lesions were evaluated at the end of the study. Simvastatin reduced intimal proliferation in the thoracic region, prevented arterial calcification and inhibited the generation of autoantibodies against oxLDL. In conclusion, daily administration of simvastatin slows down atherosclerotic lesion development in rabbits with induced hypercholesterolemia and inhibition on generation of autoantibodies against oxLDL contributes to the cardioprotective effect observed.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.publisherColegio Farmaceuticos Provincia de Buenos Aires-
dc.sourceWeb of Science-
dc.subjectAutoantibodies against oxidized LDLen
dc.titleEffect of simvastatin on the generation of autoantibodies against oxidized LDL and progression of atherosclerosis in rabbitsen
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.description.affiliationSão Paulo State Univ, Fac Pharmaceut Sci, Dept Food & Nutr, Araraquara, SP, Brazil-
dc.description.affiliationUniv São Paulo, Fac Pharmaceut Sci, Dept Clin & Toxicol Anal, São Paulo, Brazil-
dc.description.affiliationUnespSão Paulo State Univ, Fac Pharmaceut Sci, Dept Food & Nutr, Araraquara, SP, Brazil-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofLatin American Journal of Pharmacy-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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