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http://acervodigital.unesp.br/handle/11449/7201
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DC Field | Value | Language |
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dc.contributor.author | Kinouchi, Fernanda Lopes | - |
dc.contributor.author | Geraldo Maia, Danielle Cardoso | - |
dc.contributor.author | de Abreu Ribeiro, Livia Carolina | - |
dc.contributor.author | Polesi Placeres, Marisa Campos | - |
dc.contributor.author | Font de Valdez, Graciela | - |
dc.contributor.author | Luis Colombo, Lucas | - |
dc.contributor.author | Rossi, Elizeu Antonio | - |
dc.contributor.author | Carlos, Iracilda Zeppone | - |
dc.date.accessioned | 2014-05-20T13:23:42Z | - |
dc.date.accessioned | 2016-10-25T16:44:40Z | - |
dc.date.available | 2014-05-20T13:23:42Z | - |
dc.date.available | 2016-10-25T16:44:40Z | - |
dc.date.issued | 2012-11-01 | - |
dc.identifier | http://dx.doi.org/10.1016/j.fct.2012.08.038 | - |
dc.identifier.citation | Food and Chemical Toxicology. Oxford: Pergamon-Elsevier B.V. Ltd, v. 50, n. 11, p. 4144-4148, 2012. | - |
dc.identifier.issn | 0278-6915 | - |
dc.identifier.uri | http://hdl.handle.net/11449/7201 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/7201 | - |
dc.description.abstract | Purpose: Soy and its fermented products are considered functional foods. The study objective was to assess three functional food - a non-fermented soy product (NFP), fermented soy product (FSP), fermented soy product enriched with isoflavones (FI) - in terms of their ability to reduce the development of adenocarcinoma in mice, as well their ability on modulating immune system.Methods: It was observed tumor volume and to verify correlations with the immune system it was measured levels of the cytokines IL-1 beta and TNF-alpha produced by macrophages as well as IFN-gamma produced by lymphocytes using ELISA test, and nitric oxide production by macrophages using Griess reagent.Results: All products showed immunological activity, but FSP showed the most effective tumor containment, resulting in smallest tumor volumes. Fl animals expressed larger amounts of nitric oxide and IL-1 beta and exhibited larger tumor sizes than FSP and NFP animals.Conclusions: The results suggested that the ingestion of FSP was most efficient in tumor containment, possibly due to a positive modulation of the immune system by when Enterococcus faecium and Lactobacillus helveticus are added to the soy product. (C) 2012 Elsevier Ltd. All rights reserved. | en |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | - |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
dc.format.extent | 4144-4148 | - |
dc.language.iso | eng | - |
dc.publisher | Pergamon-Elsevier B.V. Ltd | - |
dc.source | Web of Science | - |
dc.subject | Soy | en |
dc.subject | Isoflavones | en |
dc.subject | Cytokine | en |
dc.subject | Cancer | en |
dc.subject | Immune system | en |
dc.title | A soy-based product fermented by Enterococcus faecium and Lactobacillus helveticus inhibits the development of murine breast adenocarcinoma | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | Centro de Referencia para Lactobacilos (CERELA) | - |
dc.description.affiliation | Univ Estadual Paulista, Fac Ciencias Farmaceut, Araraquara, SP, Brazil | - |
dc.description.affiliation | Ctr Referencia Lactobacilos, San Miguel de Tucuman, Argentina | - |
dc.description.affiliation | Inst Oncol Angel H Roffo, Buenos Aires, DF, Argentina | - |
dc.description.affiliationUnesp | Univ Estadual Paulista, Fac Ciencias Farmaceut, Araraquara, SP, Brazil | - |
dc.identifier.doi | 10.1016/j.fct.2012.08.038 | - |
dc.identifier.wos | WOS:000310654300038 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Food and Chemical Toxicology | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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