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dc.contributor.authorCavallini, Daniela Cardoso Umbelino-
dc.contributor.authorAbdalla, Dulcineia S. P.-
dc.contributor.authorVendramini, Regina Célia-
dc.contributor.authorBedani, Raquel-
dc.contributor.authorBomdespacho, Laura Q.-
dc.contributor.authorPauly-Silveira, Nadiege D.-
dc.contributor.authorde Valdez, Graciela F.-
dc.contributor.authorRossi, Elizeu Antonio-
dc.identifier.citationLipids In Health and Disease. London: Biomed Central Ltd., v. 8, p. 10, 2009.-
dc.description.abstractBackground: There is increasing interest in natural treatments to control dyslipidemia and reduce the risk of cardiovascular disease. Previous studies have demonstrated the beneficial effects of soy yogurt fermented with Enterococcus faecium CRL 183 and of dietary isoflavones on the lipid profile. The purpose of the present study was to investigate the effects of isoflavone-supplemented soy yogurt, fermented with E. faecium CRL183, on lipid parameters and atherosclerosis development in rabbits with induced hypercholesterolemia.Methods: Forty-eight rabbits were randomly assigned to eight groups fed on the following diets for 60 days: C - control; IY - isoflavone-supplemented soy yogurt; H - hypercholesterolemic (1.0% cholesterol wt/wt diet); HY - hypercholesterolemic plus soy yogurt; HIY - hypercholesterolemic plus isoflavone-supplemented soy yogurt; HP - hypercholesterolemic plus placebo; HI hypercholesterolemic plus isoflavone and HE - hypercholesterolemic plus pure culture of E. faecium CRL 183. Serum lipids and autoantibodies against oxLDL (oxLDL Ab) were analyzed on days 0, 30 and 60 of the treatment and the atherosclerotic lesions were quantified at the end of the experiment.Results: Soy yogurt, soy yogurt supplemented with isoflavones and placebo promoted significant reductions in total cholesterol level (38.1%, 27.0% and 26.6%, respectively). Significant increases in serum HDL-C concentration relative to group H were detected in animals that ingested soy yogurt, with or without the isoflavone supplement (55.2%), E. faecium culture (43.3%) or placebo (35.8%). Intake of soy yogurt and soy yogurt supplemented with isoflavones prevented the rise of oxLDL Ab during the study period. The extent of atherosclerosis in the thoracic and abdominal aortas was reduced in the HIY, HY and HP groups. However, when the whole aorta was analyzed, animals treated with soy yogurt supplemented with isoflavones exhibited the greatest reduction (51.4%, P < 0.05) in atherosclerotic lesion area, compared to group H.Conclusion: Soy yogurt could be consumed as an alternative means of reducing the risk of cardiovascular disease by improving the lipid profile and inhibiting oxLDL Ab formation. Our findings also suggest that isoflavone supplementation may enhance the antiatherosclerotic effect of soy yogurt.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.publisherBiomed Central Ltd.-
dc.sourceWeb of Science-
dc.titleEffects of isoflavone-supplemented soy yogurt on lipid parameters and atherosclerosis development in hypercholesterolemic rabbits: a randomized double-blind studyen
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionCentro de Referencia para Lactobacilos (CERELA)-
dc.description.affiliationSão Paulo State Univ, Dept Food & Nutr, Fac Pharmaceut Sci, Araraquara, SP, Brazil-
dc.description.affiliationUniv São Paulo, Fac Pharmaceut Sci, Dept Clin & Toxicol Anal, São Paulo, Brazil-
dc.description.affiliationSão Paulo State Univ, Dept Clin Anal, Fac Pharmaceut Sci, Araraquara, SP, Brazil-
dc.description.affiliationCERELA, Reference Ctr Lactobacilos, San Miguel de Tucuman, Argentina-
dc.description.affiliationUnespSão Paulo State Univ, Dept Food & Nutr, Fac Pharmaceut Sci, Araraquara, SP, Brazil-
dc.description.affiliationUnespSão Paulo State Univ, Dept Clin Anal, Fac Pharmaceut Sci, Araraquara, SP, Brazil-
dc.rights.accessRightsAcesso aberto-
dc.relation.ispartofLipids in Health and Disease-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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