beta-Conglycinin (7S) and glycinin (11S) exert a hypocholesterolemic effect comparable to that of fenofibrate in rats fed a high-cholesterol diet

Abstract

The hypocholesterolemic effect of isolated soybean proteins and fenofibrate in rats was compared Forty five rats were divided into five groups standard (STD casein) high cholesterol (HC STD plus 1% cholesterol/0 5% cholic acid) HC + beta conglycinin HC + glycinin and HC + fenofibrate The proteins and the drug were administered by gavage for 28 days The proteins decreased total cholesterol (TC) and triacylglycerol (TG) in the plasma of the rats fed HC diet to values very close to those fed on fenofibrate High density lipoprotein cholesterol (HDL C) levels in the plasma were increased by the beta conglycinin glycinin and fenofibrate groups The largest TC reduction in the liver was observed in the fenofibrate group, in contrast the beta conglycinin and glycinin groups exhibited reduced the levels of hepatic TG and TC Based on these data it could be suggested that the oral daily administration of isolated soybean proteins in the range of 2 75% of the protein ingested daily can promote a reduction in TC and TG in the plasma of rats fed hypercholesterolemic diets Crown Copyright (C) 2010 Published by Elsevier Ltd All rights reserved