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http://acervodigital.unesp.br/handle/11449/72173
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DC Field | Value | Language |
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dc.contributor.author | Chaves, Izabel S. | - |
dc.contributor.author | Rodrigues, Stella G. | - |
dc.contributor.author | Melo, Nathalie F.S. | - |
dc.contributor.author | de Jesus, Marcelo B. | - |
dc.contributor.author | Fraceto, Leonardo F. | - |
dc.contributor.author | de Paula, Eneida | - |
dc.contributor.author | Pinto, Luciana M.A. | - |
dc.date.accessioned | 2014-05-27T11:25:24Z | - |
dc.date.accessioned | 2016-10-25T18:33:13Z | - |
dc.date.available | 2014-05-27T11:25:24Z | - |
dc.date.available | 2016-10-25T18:33:13Z | - |
dc.date.issued | 2010-12-01 | - |
dc.identifier | http://www.latamjpharm.org/resumenes/29/7/LAJOP_29_7_1_2.pdf | - |
dc.identifier.citation | Latin American Journal of Pharmacy, v. 29, n. 7, p. 1067-1074, 2010. | - |
dc.identifier.issn | 0326-2383 | - |
dc.identifier.uri | http://hdl.handle.net/11449/72173 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/72173 | - |
dc.description.abstract | Praziquantel (PZQ) is the drug of choice commonly used for the treatment of shistosomiasis. However, it has low aqueous solubility, which could limit its bioavailability in the body. To circumvent these features, an inclusion complex with hydroxypropyl-beta- cyclodextrin (HP-β-CD) was prepared. Thus, the objective of this work was to prepare and characterize the PZQ/HP-β-CD inclusion complex. Morphological, spectroscopic, and calorimetric analysis showed the first signs of the guest/host interaction. The complexation kinetic analysis was used to determine the kinetic constant and, besides that, it was possible to establish the time consumed to reach equilibrium. Using the solubility isotherm, it was observed that the interaction with HP-β-CD increased 2.4 fold the aqueous solubility of plain PZQ. In vitro cytotoxicity tests, using fibroblast cells, evidenced no toxicity for these cells at the concentrations tested. These results demonstrated that there is a potential use of PZQ in formulations with HP-β-CD. | en |
dc.format.extent | 1067-1074 | - |
dc.language.iso | por | - |
dc.source | Scopus | - |
dc.subject | Cyclodextrin | - |
dc.subject | Inclusion complex | - |
dc.subject | Praziquantel | - |
dc.subject | Schistosomiasis | - |
dc.subject | 2 hydroxypropyl beta cyclodextrin | - |
dc.subject | praziquantel | - |
dc.subject | calorimetry | - |
dc.subject | chemical interaction | - |
dc.subject | complex formation | - |
dc.subject | cytotoxicity | - |
dc.subject | drug formulation | - |
dc.subject | drug solubility | - |
dc.subject | drug structure | - |
dc.subject | fibroblast culture | - |
dc.subject | in vitro study | - |
dc.subject | isotherm | - |
dc.subject | morphology | - |
dc.subject | physical chemistry | - |
dc.subject | schistosomiasis | - |
dc.subject | spectroscopy | - |
dc.title | Alternativas para o tratamento da esquistossomose: Caracterizacao fisico-quimica do complexo de inclusao entre praziquantel e hidroxipropil-β-ciclodextrina | pt |
dc.title.alternative | Alternatives for the treatment of schistosomiasis: Physico-chemical characterization of an inclusion complex between praziquantel and hydroxypropyl-β-cyclodextrin | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Federal de Lavras (UFLA) | - |
dc.contributor.institution | Universidade Estadual de Campinas (UNICAMP) | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | Departamento de Química Universidade Federal de Lavras, Caixa Postal: 3037, Lavras - MG, CEP: 37200-000 | - |
dc.description.affiliation | Departamento de Bioquímica Instituto de Biologia Universidade Estadual de Campinas | - |
dc.description.affiliation | Departamento de Engenharia Ambiental Universidade Estadual Paulista, Júlio de Mesquita | - |
dc.description.affiliationUnesp | Departamento de Engenharia Ambiental Universidade Estadual Paulista, Júlio de Mesquita | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Latin American Journal of Pharmacy | - |
dc.identifier.scopus | 2-s2.0-78650807875 | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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