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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/72173
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dc.contributor.authorChaves, Izabel S.-
dc.contributor.authorRodrigues, Stella G.-
dc.contributor.authorMelo, Nathalie F.S.-
dc.contributor.authorde Jesus, Marcelo B.-
dc.contributor.authorFraceto, Leonardo F.-
dc.contributor.authorde Paula, Eneida-
dc.contributor.authorPinto, Luciana M.A.-
dc.date.accessioned2014-05-27T11:25:24Z-
dc.date.accessioned2016-10-25T18:33:13Z-
dc.date.available2014-05-27T11:25:24Z-
dc.date.available2016-10-25T18:33:13Z-
dc.date.issued2010-12-01-
dc.identifierhttp://www.latamjpharm.org/resumenes/29/7/LAJOP_29_7_1_2.pdf-
dc.identifier.citationLatin American Journal of Pharmacy, v. 29, n. 7, p. 1067-1074, 2010.-
dc.identifier.issn0326-2383-
dc.identifier.urihttp://hdl.handle.net/11449/72173-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/72173-
dc.description.abstractPraziquantel (PZQ) is the drug of choice commonly used for the treatment of shistosomiasis. However, it has low aqueous solubility, which could limit its bioavailability in the body. To circumvent these features, an inclusion complex with hydroxypropyl-beta- cyclodextrin (HP-β-CD) was prepared. Thus, the objective of this work was to prepare and characterize the PZQ/HP-β-CD inclusion complex. Morphological, spectroscopic, and calorimetric analysis showed the first signs of the guest/host interaction. The complexation kinetic analysis was used to determine the kinetic constant and, besides that, it was possible to establish the time consumed to reach equilibrium. Using the solubility isotherm, it was observed that the interaction with HP-β-CD increased 2.4 fold the aqueous solubility of plain PZQ. In vitro cytotoxicity tests, using fibroblast cells, evidenced no toxicity for these cells at the concentrations tested. These results demonstrated that there is a potential use of PZQ in formulations with HP-β-CD.en
dc.format.extent1067-1074-
dc.language.isopor-
dc.sourceScopus-
dc.subjectCyclodextrin-
dc.subjectInclusion complex-
dc.subjectPraziquantel-
dc.subjectSchistosomiasis-
dc.subject2 hydroxypropyl beta cyclodextrin-
dc.subjectpraziquantel-
dc.subjectcalorimetry-
dc.subjectchemical interaction-
dc.subjectcomplex formation-
dc.subjectcytotoxicity-
dc.subjectdrug formulation-
dc.subjectdrug solubility-
dc.subjectdrug structure-
dc.subjectfibroblast culture-
dc.subjectin vitro study-
dc.subjectisotherm-
dc.subjectmorphology-
dc.subjectphysical chemistry-
dc.subjectschistosomiasis-
dc.subjectspectroscopy-
dc.titleAlternativas para o tratamento da esquistossomose: Caracterizacao fisico-quimica do complexo de inclusao entre praziquantel e hidroxipropil-β-ciclodextrinapt
dc.title.alternativeAlternatives for the treatment of schistosomiasis: Physico-chemical characterization of an inclusion complex between praziquantel and hydroxypropyl-β-cyclodextrinen
dc.typeoutro-
dc.contributor.institutionUniversidade Federal de Lavras (UFLA)-
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationDepartamento de Química Universidade Federal de Lavras, Caixa Postal: 3037, Lavras - MG, CEP: 37200-000-
dc.description.affiliationDepartamento de Bioquímica Instituto de Biologia Universidade Estadual de Campinas-
dc.description.affiliationDepartamento de Engenharia Ambiental Universidade Estadual Paulista, Júlio de Mesquita-
dc.description.affiliationUnespDepartamento de Engenharia Ambiental Universidade Estadual Paulista, Júlio de Mesquita-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofLatin American Journal of Pharmacy-
dc.identifier.scopus2-s2.0-78650807875-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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