You are in the accessibility menu

Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/72301
Full metadata record
DC FieldValueLanguage
dc.contributor.authorTerneux, Eduardo Wladimir Avilés-
dc.contributor.authorPontes, Davi Abeid-
dc.contributor.authorFernandez, Carla Dal Bianco-
dc.contributor.authorArena, Arielle Cristina-
dc.contributor.authorPorto, Elaine Manoela-
dc.contributor.authorde Kempinas, Wilma Grava-
dc.date.accessioned2014-05-27T11:25:28Z-
dc.date.accessioned2016-10-25T18:33:34Z-
dc.date.available2014-05-27T11:25:28Z-
dc.date.available2016-10-25T18:33:34Z-
dc.date.issued2011-02-01-
dc.identifierhttp://dx.doi.org/10.1080/02772248.2010.523930-
dc.identifier.citationToxicological and Environmental Chemistry, v. 93, n. 2, p. 345-351, 2011.-
dc.identifier.issn0277-2248-
dc.identifier.issn1029-0486-
dc.identifier.urihttp://hdl.handle.net/11449/72301-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/72301-
dc.description.abstractIvermectin is one of the most widely used antiparasitic drugs globally. The aim of this study was to evaluate the chronic effects of perinatal exposure to ivermectin on male reproductive parameters in rats. Pregnant rats were treated daily by oral gavage with 0.4 or 1.6 mg kg -1 of ivermectin or vehicle, from gestational day 6 until post-natal day 10. In the adulthood stage, there were significant reductions in the relative testicular weight of rats exposed to the low dose and in relative prostate weight of male rats exposed to the high dose of ivermectin. Furthermore, the animals exposed to the low dose also presented an increased seminal vesicle weight compared to controls. However, neither of the ivermectin doses interfered in daily sperm production, sperm number in testis, or sexual behavior of exposed males. In conclusion, perinatal exposure to ivermectin neither altered the male reproductive system development markedly, nor produced any adverse effects on the parameters evaluated. © 2011 Taylor & Francis.en
dc.format.extent345-351-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectGestation-
dc.subjectIvermectin-
dc.subjectMale reproductive system-
dc.subjectParasiticide-
dc.subjectRat-
dc.subjectAdverse effect-
dc.subjectAntiparasitic drugs-
dc.subjectChronic effects-
dc.subjectHigh dose-
dc.subjectLong-term effects-
dc.subjectLow dose-
dc.subjectMale rats-
dc.subjectPregnant rat-
dc.subjectReproductive systems-
dc.subjectSeminal vesicle-
dc.subjectAnimals-
dc.subjectRats-
dc.subjectdevelopmental biology-
dc.subjectdose-response relationship-
dc.subjectivermectin-
dc.subjectmale-
dc.subjectpollution effect-
dc.subjectpollution exposure-
dc.subjectpregnancy-
dc.subjectreproductive strategy-
dc.subjectrodent-
dc.subjectsecondary sexual characteristics-
dc.subjectsperm-
dc.subjectAnimalia-
dc.subjectRattus-
dc.titlePerinatal exposure to parasiticide ivermectin: Long-term effects on reproductive parameters of adult male ratsen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)-
dc.contributor.institutionUniversidade Federal da Grande Dourados (UFGD)-
dc.description.affiliationDepartamento de Morfologia Instituto de Biociências Universidade Estadual Paulista-UNESP, Botucatu, SP-
dc.description.affiliationPrograma de Pós-graduação em Biologia Celular e Estrutural Instituto de Biologia Universidade Estadual de Campinas-UNICAMP, Campinas, SP-
dc.description.affiliationFaculdade de Ciências da Saúde Universidade Federal da Grande Dourados-UFGD, Dourados, MS-
dc.description.affiliationUnespDepartamento de Morfologia Instituto de Biociências Universidade Estadual Paulista-UNESP, Botucatu, SP-
dc.identifier.doi10.1080/02772248.2010.523930-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofToxicological and Environmental Chemistry-
dc.identifier.scopus2-s2.0-78649828380-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

There are no files associated with this item.
 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.