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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/72320
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dc.contributor.authorda Silva, Lidia Maria Rebolho Batista-
dc.contributor.authorda Silva, Jéssika Nunes Gomes-
dc.contributor.authorGalbiatti, Ana Lívia Silva-
dc.contributor.authorSucci, Maysa-
dc.contributor.authorRuiz, Mariangela Torreglosa-
dc.contributor.authorRaposo, Luiz Sérgio-
dc.contributor.authorManiglia, José Víctor-
dc.contributor.authorPavarino-Bertelli, Érika Cristina-
dc.contributor.authorGoloni-Bertollo, Eny Maria-
dc.date.accessioned2014-05-27T11:25:28Z-
dc.date.accessioned2016-10-25T18:33:36Z-
dc.date.available2014-05-27T11:25:28Z-
dc.date.available2016-10-25T18:33:36Z-
dc.date.issued2011-03-01-
dc.identifierhttp://dx.doi.org/10.1016/S2255-4823(11)70043-1-
dc.identifier.citationRevista da Associacao Medica Brasileira, v. 57, n. 2, p. 188-193, 2011.-
dc.identifier.issn0104-4230-
dc.identifier.urihttp://hdl.handle.net/11449/72320-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/72320-
dc.description.abstractObjective: To investigate the MTHFD1 G1958A polymorphism involved in the folate metabolism as a risk for head and neck cancer, and to find the association of the polymorphism with the risk factors and clinical and histopathological characteristics. Methods: Retrospective study investigating MTHFD1 G1958A polymorphism in 694 subjects (240 patients in the Case Group and 454 in the Control Group) by Restriction Fragment Length Polymorphism (RFLP) Analysis. Multiple logistic regression and chi-square tests were used in the statistical analysis. Results: Multivariable analysis showed that smoking and age over 42 years were disease predictors (p < 0.05). MTHFD1 1958GA or AA genotypes were associated with smoking (p = 0.04) and alcoholism (p = 0.03) and were more ofen found in more advanced stage tumors (p = 0.04) and in patients with a shorter survival (p = 0.03). Conclusion: Te presence of MTHFD1 G1948A polymorphism associated with smoking and alcoholism raises the head and neck cancer risk.en
dc.format.extent188-193-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectAlcoholism-
dc.subjectGenetic-
dc.subjectHead and neck neoplasms-
dc.subjectMe-hylenetetrahydrofolate dehydrogenase (NADP)-
dc.subjectPolymorphism-
dc.subjectSmoking-
dc.titleHead and neck carcinogenesis: Impact of MTHFD1 G1958A polymorphismen
dc.typeoutro-
dc.contributor.institutionFaculdade de Medicina de São José do Rio Preto (FAMERP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationResearch in Genetics and Molecular Biology -UPGEM Medical College of São José do Rio Preto - FAMERP, São José do Rio Preto, SP-
dc.description.affiliationLanguage and Hearing Sciences FAMERP, São José do Rio Preto, SP-
dc.description.affiliationUPGEM/ FAMERP, São José do Rio Preto, SP-
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho - Unesp, São José do Rio Preto, SP-
dc.description.affiliationFAMERP, São José do Rio Preto, SP-
dc.description.affiliationDepartment of Otorhinolaryngology and Head and Neck Surgery FAMERP, São José do Rio-
dc.description.affiliationDepartment of Molecular Biology FAMERP, São José do Rio Preto, SP-
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho - Unesp, São José do Rio Preto, SP-
dc.identifier.doi10.1016/S2255-4823(11)70043-1-
dc.rights.accessRightsAcesso aberto-
dc.identifier.file2-s2.0-79955739445.pdf-
dc.relation.ispartofRevista da Associação Médica Brasileira-
dc.identifier.scopus2-s2.0-79955739445-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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